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Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis

Cancer cell, 2015-07, Vol.28 (1), p.42-56

2015

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Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells

Science (American Association for the Advancement of Science), 2010-09, Vol.329 (5997), p.1345-1348

2010

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Fluorophore-NanoLuc BRET Reporters Enable Sensitive In Vivo Optical Imaging and Flow Cytometry for Monitoring Tumorigenesis

Cancer research (Chicago, Ill.), 2015-12, Vol.75 (23), p.5023-5033

2015

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Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis

PloS one, 2014-07, Vol.9 (7), p.e101969-e101969

2014

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Rev-erbα heterozygosity produces a dose-dependent phenotypic advantage in mice

PloS one, 2020-05, Vol.15 (5), p.e0227720-e0227720

2020

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A two-hit model of alcoholic liver disease that exhibits rapid, severe fibrosis

PloS one, 2021-03, Vol.16 (3), p.e0249316

2021

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The Uremic Toxin 3-Indoxyl Sulfate Is a Potent Endogenous Agonist for the Human Aryl Hydrocarbon Receptor

Biochemistry (Easton), 2010-01, Vol.49 (2), p.393-400

2010

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Ligand Selectivity and Gene Regulation by the Human Aryl Hydrocarbon Receptor in Transgenic Mice

Molecular pharmacology, 2009-06, Vol.75 (6), p.1412-1420

2009

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Pyrvinium Attenuates Hedgehog Signaling Downstream of Smoothened

Cancer research (Chicago, Ill.), 2014-09, Vol.74 (17), p.4811-4821

2014

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Evidence for Ligand-Mediated Selective Modulation of Aryl Hydrocarbon Receptor Activity

Molecular pharmacology, 2010-02, Vol.77 (2), p.247-254

2010

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CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibition

Cell reports (Cambridge), 2021-02, Vol.34 (8), p.108768-108768, Article 108768

2021

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The LXR inverse agonist SR9238 suppresses fibrosis in a model of non-alcoholic steatohepatitis

Molecular metabolism (Germany), 2015-04, Vol.4 (4), p.353-357

2015

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Antagonism of aryl hydrocarbon receptor signaling by 6,2',4'-trimethoxyflavone

The Journal of pharmacology and experimental therapeutics, 2010-01, Vol.332 (1), p.135-144

2010

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Rev-Erb co-regulates muscle regeneration via tethered interaction with the NF-Y cistrome

Molecular metabolism (Germany), 2017-07, Vol.6 (7), p.703-714

2017

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Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

Toxicological sciences, 2010-05, Vol.115 (1), p.89-97

2010

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LXR-inverse agonism stimulates immune-mediated tumor destruction by enhancing CD8 T-cell activity in triple negative breast cancer

Scientific reports, 2019-12, Vol.9 (1), p.19530-18, Article 19530

2019

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Combined regenerative rehabilitation improves recovery following volumetric muscle loss injury in a rat model

Journal of biomedical materials research. Part B, Applied biomaterials, 2024-07, Vol.112 (7), p.e35438-n/a

2024

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Differential Gene Regulation by the Human and Mouse Aryl Hydrocarbon Receptor

Toxicological sciences, 2010-04, Vol.114 (2), p.217-225

2010

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Pharmacological inhibition of REV-ERB stimulates differentiation, inhibits turnover and reduces fibrosis in dystrophic muscle

Scientific reports, 2017-12, Vol.7 (1), p.17142-13, Article 17142

2017

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Retinal Degeneration: Short-Term Options and Long-Term Vision for Future Therapy

Missouri medicine, 2021-09, Vol.118 (5), p.466-472

2021

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REV-ERB and ROR: therapeutic targets for treating myopathies

Physical biology, 2017-06, Vol.14 (4), p.045002-045002

2017

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Ah receptor represses acute-phase response gene expression without binding to its cognate response element

Laboratory investigation, 2009-06, Vol.89 (6), p.695-707

2009

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Inhibition of Hepatotoxicity by a LXR Inverse Agonist in a Model of Alcoholic Liver Disease

ACS pharmacology & translational science, 2018-09, Vol.1 (1), p.50-60

2018

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Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3',4'-dimethoxy-α-naphthoflavone

Molecular pharmacology, 2011-03, Vol.79 (3), p.508-519

2011

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Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis

Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells

Fluorophore-NanoLuc BRET Reporters Enable Sensitive In Vivo Optical Imaging and Flow Cytometry for Monitoring Tumorigenesis

Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis

Rev-erbα heterozygosity produces a dose-dependent phenotypic advantage in mice

A two-hit model of alcoholic liver disease that exhibits rapid, severe fibrosis

The Uremic Toxin 3-Indoxyl Sulfate Is a Potent Endogenous Agonist for the Human Aryl Hydrocarbon Receptor

International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily-Update 2023

Ligand Selectivity and Gene Regulation by the Human Aryl Hydrocarbon Receptor in Transgenic Mice

Pyrvinium Attenuates Hedgehog Signaling Downstream of Smoothened

Evidence for Ligand-Mediated Selective Modulation of Aryl Hydrocarbon Receptor Activity

CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibition

The LXR inverse agonist SR9238 suppresses fibrosis in a model of non-alcoholic steatohepatitis

Antagonism of aryl hydrocarbon receptor signaling by 6,2',4'-trimethoxyflavone

Rev-Erb co-regulates muscle regeneration via tethered interaction with the NF-Y cistrome

Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

LXR-inverse agonism stimulates immune-mediated tumor destruction by enhancing CD8 T-cell activity in triple negative breast cancer

Combined regenerative rehabilitation improves recovery following volumetric muscle loss injury in a rat model

Differential Gene Regulation by the Human and Mouse Aryl Hydrocarbon Receptor

Pharmacological inhibition of REV-ERB stimulates differentiation, inhibits turnover and reduces fibrosis in dystrophic muscle

Retinal Degeneration: Short-Term Options and Long-Term Vision for Future Therapy

REV-ERB and ROR: therapeutic targets for treating myopathies

Ah receptor represses acute-phase response gene expression without binding to its cognate response element

Inhibition of Hepatotoxicity by a LXR Inverse Agonist in a Model of Alcoholic Liver Disease

Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3',4'-dimethoxy-α-naphthoflavone

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