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Catabolism of Fibromodulin in Developmental Rudiment and Pathologic Articular Cartilage Demonstrates Novel Roles for MMP-13 and ADAMTS-4 in C-terminal Processing of SLRPs

International journal of molecular sciences, 2019-01, Vol.20 (3), p.579

2019

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Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

Nature, 2005-03, Vol.434 (7033), p.644-648

2005

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Serine protease HTRA1 antagonizes transforming growth factor-β signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation

PloS one, 2013, Vol.8 (9), p.e74094-e74094

2013

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Novel therapies in OA

Current drug targets, 2010-05, Vol.11 (5), p.614-619

Flannery, Carl R

2010

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Boundary mode lubrication of articular cartilage by recombinant human lubricin

Journal of orthopaedic research, 2009-06, Vol.27 (6), p.771-777

2009

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MMPs and ADAMTSs: functional studies

Frontiers in bioscience, 2006-01, Vol.11 (1), p.544

Flannery, Carl R

2006

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Tenascin-C induces inflammatory mediators and matrix degradation in osteoarthritic cartilage

BMC musculoskeletal disorders, 2011-07, Vol.12 (1), p.164-164, Article 164

2011

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LXR modulation blocks prostaglandin E₂ production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model

Proceedings of the National Academy of Sciences - PNAS, 2010-02, Vol.107 (8), p.3734-3739

2010

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Binding and localization of recombinant lubricin to articular cartilage surfaces

Journal of orthopaedic research, 2007-03, Vol.25 (3), p.283-292

2007

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Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254)

Arthritis research & therapy, 2010-01, Vol.12 (6), p.R229-R229, Article R229

2010

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ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage

Matrix biology, 2004-07, Vol.23 (4), p.219-230

2004

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Autocatalytic Cleavage of ADAMTS-4 (Aggrecanase-1) Reveals Multiple Glycosaminoglycan-binding Sites

The Journal of biological chemistry, 2002-11, Vol.277 (45), p.42775-42780

2002

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Immunolocalisation and expression of proteoglycan 4 (cartilage superficial zone proteoglycan) in tendon

Matrix biology, 2002-11, Vol.21 (7), p.593-602

2002

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Not All Lubricin Isoforms Are Substituted with a Glycosaminoglycan Chain

Connective tissue research, 2012-04, Vol.53 (2), p.132-141

2012

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Composition and Bioactivity of a Placental Tissue Particulate (PTP-001) Indicate Greater Potential than Platelet-Rich Plasma for the Treatment of Osteoarthritis

Cartilage, 2023-12, Vol.14 (4), p.467-472

2023

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Systematic clinical evidence review of NASHA (Durolane hyaluronic acid) for the treatment of knee osteoarthritis

Open access rheumatology: research and reviews, 2018-01, Vol.10, p.43-54

2018

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Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation

Matrix biology, 2002-04, Vol.21 (3), p.271-288

2002

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Destabilization of the medial meniscus to induce post-traumatic osteoarthritis in domestic pigs

The journal of cartilage & joint preservation, 2023-12, Vol.3 (4), p.100139, Article 100139

2023

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Identification of a Novel HtrA1-susceptible Cleavage Site in Human Aggrecan: EVIDENCE FOR THE INVOLVEMENT OF HtrA1 IN AGGRECAN PROTEOLYSIS IN VIVO

The Journal of biological chemistry, 2009-10, Vol.284 (40), p.27352-27359

2009

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Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes

Matrix biology, 1999-06, Vol.18 (3), p.225-237

1999

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Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis

Arthritis research & therapy, 2006-01, Vol.8 (2), p.R41-R41, Article R41

2006

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Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: Comparative analyses with ADAMTS-5, -9, -16 and -18

Biochimica et biophysica acta, 2006-03, Vol.1760 (3), p.517-524

2006

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Mechanisms involved in cartilage proteoglycan catabolism

Matrix biology, 2000-08, Vol.19 (4), p.333-344

2000

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N-((8-Hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2)

Bioorganic & medicinal chemistry, 2008-12, Vol.18 (24), p.6454-6457

2008

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n-3 Fatty Acids Specifically Modulate Catabolic Factors Involved in Articular Cartilage Degradation

The Journal of biological chemistry, 2000-01, Vol.275 (2), p.721-724

2000

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Catabolism of Fibromodulin in Developmental Rudiment and Pathologic Articular Cartilage Demonstrates Novel Roles for MMP-13 and ADAMTS-4 in C-terminal Processing of SLRPs

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

Serine protease HTRA1 antagonizes transforming growth factor-β signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation

Novel therapies in OA

Boundary mode lubrication of articular cartilage by recombinant human lubricin

MMPs and ADAMTSs: functional studies

Tenascin-C induces inflammatory mediators and matrix degradation in osteoarthritic cartilage

LXR modulation blocks prostaglandin E₂ production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model

Binding and localization of recombinant lubricin to articular cartilage surfaces

Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254)

ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage

Autocatalytic Cleavage of ADAMTS-4 (Aggrecanase-1) Reveals Multiple Glycosaminoglycan-binding Sites

Immunolocalisation and expression of proteoglycan 4 (cartilage superficial zone proteoglycan) in tendon

Not All Lubricin Isoforms Are Substituted with a Glycosaminoglycan Chain

Composition and Bioactivity of a Placental Tissue Particulate (PTP-001) Indicate Greater Potential than Platelet-Rich Plasma for the Treatment of Osteoarthritis

Systematic clinical evidence review of NASHA (Durolane hyaluronic acid) for the treatment of knee osteoarthritis

Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation

Destabilization of the medial meniscus to induce post-traumatic osteoarthritis in domestic pigs

Identification of a Novel HtrA1-susceptible Cleavage Site in Human Aggrecan: EVIDENCE FOR THE INVOLVEMENT OF HtrA1 IN AGGRECAN PROTEOLYSIS IN VIVO

Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes

Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis

Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: Comparative analyses with ADAMTS-5, -9, -16 and -18

Mechanisms involved in cartilage proteoglycan catabolism

N-((8-Hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2)

n-3 Fatty Acids Specifically Modulate Catabolic Factors Involved in Articular Cartilage Degradation

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