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Inhibition of lactic dehydrogenase as a way to increase the anti-proliferative effect of multi-targeted kinase inhibitors

Pharmacological research, 2011-04, Vol.63 (4), p.328-334

2011

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Comment on: Targeting homologous recombination-mediated DNA repair in cancer

Expert opinion on therapeutic targets, 2014-07, Vol.18 (7), p.833-833

Fiume, Luigi

2014

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A novel method for coupling doxorubicin to lactosaminated human albumin by an acid sensitive hydrazone bond: synthesis, characterization and preliminary biological properties of the conjugate

European journal of pharmaceutical sciences, 2004-12, Vol.23 (4), p.393-397

2004

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Doxorubicin coupled to lactosaminated albumin inhibits the growth of hepatocellular carcinomas induced in rats by diethylnitrosamine

Journal of hepatology, 2005-10, Vol.43 (4), p.645-652

2005

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Inhibition of lactate dehydrogenase activity as an approach to cancer therapy

Future medicinal chemistry, 2014-03, Vol.6 (4), p.429-445

2014

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Lactosaminated human albumin, a hepatotropic carrier of drugs

European journal of pharmaceutical sciences, 2010-07, Vol.40 (4), p.253-262

2010

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The inhibition of lactate dehydrogenase A hinders the transcription of histone 2B gene independently from the block of aerobic glycolysis

Biochemical and biophysical research communications, 2017-04, Vol.485 (4), p.742-745

2017

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Doxorubicin coupled to lactosaminated albumin: Effect of heterogeneity in drug load on conjugate disposition and hepatocellular carcinoma uptake in rats

European journal of pharmaceutical sciences, 2008-02, Vol.33 (2), p.191-198

2008

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Lactate dehydrogenase inhibitors sensitize lymphoma cells to cisplatin without enhancing the drug effects on immortalized normal lymphocytes

European journal of pharmaceutical sciences, 2015-07, Vol.74, p.95-102

2015

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Lactate dehydrogenase inhibition: exploring possible applications beyond cancer treatment

Future medicinal chemistry, 2016-04, Vol.8 (6), p.713-725

2016

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Liver-targeted doxorubicin: effects on rat regenerating hepatocytes

Liver international, 2004-06, Vol.24 (3), p.246-252

2004

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Galloflavin (CAS 568-80-9): A Novel Inhibitor of Lactate Dehydrogenase

ChemMedChem, 2012-02, Vol.7 (2), p.311-317

2012

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Albumin-drug conjugates in the treatment of hepatic disorders

Expert opinion on drug delivery, 2014-08, Vol.11 (8), p.1203-1217

2014

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Effect of sorafenib on the energy metabolism of hepatocellular carcinoma cells

European journal of pharmacology, 2011-11, Vol.670 (1), p.39-43

2011

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Impairment of Aerobic Glycolysis by Inhibitors of Lactic Dehydrogenase Hinders the Growth of Human Hepatocellular Carcinoma Cell Lines

Pharmacology, 2010-01, Vol.86 (3), p.157-162

2010

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Conjugates of nucleoside analogs with lactosaminated human albumin to selectively increase the drug levels in liver blood: requirements for a regional chemotherapy

The Journal of pharmacology and experimental therapeutics, 2002-05, Vol.301 (2), p.638-642

2002

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Doxorubicin coupled to lactosaminated human albumin: a hepatocellular carcinoma targeted drug

Drug discovery today, 2008-11, Vol.13 (21), p.1002-1009

2008

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Selective delivery to the liver of antiviral nucleoside analogs coupled to a high molecular mass lactosaminated poly- l-lysine and administered to mice by intramuscular route

Biochemical pharmacology, 1995-06, Vol.49 (12), p.1769-1775

1995

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A conjugate of doxorubicin with lactosaminated albumin enhances the drug concentrations in all the forms of rat hepatocellular carcinomas independently of their differentiation grade

Liver international, 2006-08, Vol.26 (6), p.726-733

2006

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Coupling of lactose molecules to the carrier protein hinders the spleen and bone marrow uptake of doxorubicin conjugated with human albumin

European journal of pharmaceutical sciences, 2007-02, Vol.30 (2), p.136-142

2007

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Characterisation of the conjugate of the (6-maleimidocaproyl)hydrazone derivative of doxorubicin with lactosaminated human albumin by 13C NMR spectroscopy

European journal of pharmaceutical sciences, 2009-10, Vol.38 (3), p.262-269

2009

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Enhanced uptake of lactosaminated human albumin by rat hepatocarcinomas: implications for an improved chemotherapy of primary liver tumors

Liver international, 2005-08, Vol.25 (4), p.854-860

2005

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Adenine arabinoside monophosphate and acyclovir monophosphate coupled to lactosaminated albumin reduce woodchuck hepatitis virus viremia at doses lower than do the unconjugated drugs

Hepatology (Baltimore, Md.), 1991-07, Vol.14 (1), p.16-24

1991

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Synthesis and physicochemical characteristics of a liver-targeted conjugate of fluorodeoxyuridine monophosphate with lactosaminated human albumin

Rapid communications in mass spectrometry, 2003-01, Vol.17 (22), p.2503-2507

2003

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Ribavirin conjugated with lactosaminated poly- l-lysine : Selective delivery to the liver and increased antiviral activity in mice with viral hepatitis

Biochemical pharmacology, 1997-08, Vol.54 (3), p.357-363

1997

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Inhibition of lactic dehydrogenase as a way to increase the anti-proliferative effect of multi-targeted kinase inhibitors

Comment on: Targeting homologous recombination-mediated DNA repair in cancer

A novel method for coupling doxorubicin to lactosaminated human albumin by an acid sensitive hydrazone bond: synthesis, characterization and preliminary biological properties of the conjugate

Doxorubicin coupled to lactosaminated albumin inhibits the growth of hepatocellular carcinomas induced in rats by diethylnitrosamine

Inhibition of lactate dehydrogenase activity as an approach to cancer therapy

Lactosaminated human albumin, a hepatotropic carrier of drugs

The inhibition of lactate dehydrogenase A hinders the transcription of histone 2B gene independently from the block of aerobic glycolysis

Doxorubicin coupled to lactosaminated albumin: Effect of heterogeneity in drug load on conjugate disposition and hepatocellular carcinoma uptake in rats

Lactate dehydrogenase inhibitors sensitize lymphoma cells to cisplatin without enhancing the drug effects on immortalized normal lymphocytes

Lactate dehydrogenase inhibition: exploring possible applications beyond cancer treatment

Liver-targeted doxorubicin: effects on rat regenerating hepatocytes

Galloflavin (CAS 568-80-9): A Novel Inhibitor of Lactate Dehydrogenase

Albumin-drug conjugates in the treatment of hepatic disorders

Effect of sorafenib on the energy metabolism of hepatocellular carcinoma cells

Impairment of Aerobic Glycolysis by Inhibitors of Lactic Dehydrogenase Hinders the Growth of Human Hepatocellular Carcinoma Cell Lines

Conjugates of nucleoside analogs with lactosaminated human albumin to selectively increase the drug levels in liver blood: requirements for a regional chemotherapy

Doxorubicin coupled to lactosaminated human albumin: a hepatocellular carcinoma targeted drug

Selective delivery to the liver of antiviral nucleoside analogs coupled to a high molecular mass lactosaminated poly- l-lysine and administered to mice by intramuscular route

A conjugate of doxorubicin with lactosaminated albumin enhances the drug concentrations in all the forms of rat hepatocellular carcinomas independently of their differentiation grade

Coupling of lactose molecules to the carrier protein hinders the spleen and bone marrow uptake of doxorubicin conjugated with human albumin

Characterisation of the conjugate of the (6-maleimidocaproyl)hydrazone derivative of doxorubicin with lactosaminated human albumin by 13C NMR spectroscopy

Enhanced uptake of lactosaminated human albumin by rat hepatocarcinomas: implications for an improved chemotherapy of primary liver tumors

Adenine arabinoside monophosphate and acyclovir monophosphate coupled to lactosaminated albumin reduce woodchuck hepatitis virus viremia at doses lower than do the unconjugated drugs

Synthesis and physicochemical characteristics of a liver-targeted conjugate of fluorodeoxyuridine monophosphate with lactosaminated human albumin

Ribavirin conjugated with lactosaminated poly- l-lysine : Selective delivery to the liver and increased antiviral activity in mice with viral hepatitis

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