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Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein

Nature (London), 2012-04, Vol.484 (7392), p.125-129

2012

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ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth

Nature chemical biology, 2021-08, Vol.17 (8), p.856

2021

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Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance

eLife, 2019-08, Vol.8

2019

Volltextzugriff (PDF)

Preclinical efficacy of MEK inhibition in Nras-mutant AML

Blood, 2014-12, Vol.124 (26), p.3947-3955

2014

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Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

Proceedings of the National Academy of Sciences - PNAS, 2009-08, Vol.106 (33), p.14132-14137

2009

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Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers

Cell reports (Cambridge), 2019-10, Vol.29 (1), p.118-134.e8

2019

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Controlling Destiny through Chemistry: Small-Molecule Regulators of Cell Fate

ACS chemical biology, 2010-01, Vol.5 (1), p.15-34

2010

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Monoallelic loss of the imprinted gene Grb10 promotes tumor formation in irradiated Nf1+/- mice

PLoS genetics, 2015-05, Vol.11 (5), p.e1005235

2015

Volltextzugriff (PDF)

Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation

Cancer discovery, 2013-09, Vol.3 (9), p.993-1001

2013

Volltextzugriff (PDF)

KRAS insertion mutations are oncogenic and exhibit distinct functional properties

Nature communications, 2016-02, Vol.7 (1), p.10647-10647, Article 10647

2016

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Arhgap36-dependent activation of Gli transcription factors

Proceedings of the National Academy of Sciences - PNAS, 2014-07, Vol.111 (30), p.11061-11066

2014

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Correction: Monoallelic Loss of the Imprinted Gene Grb10 Promotes Tumor Formation in Irradiated Nf1+/- Mice

PLoS genetics, 2015-06, Vol.11 (6), p.e1005327-e1005327

2015

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A three-drug combination to treat BRAF-mutant cancers

Nature medicine, 2017-08, Vol.23 (8), p.913-914

2017

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KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer

Cell, 2017-02, Vol.168 (5), p.817-829.e15

2017

Volltextzugriff (PDF)

Imidazopyridine Derivative JK184 Reveals Dual Roles for Microtubules in Hedgehog Signaling

Angewandte Chemie (International ed.), 2009-01, Vol.48 (13), p.2321-2324

2009

Volltextzugriff (PDF)

Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo

Journal of medicinal chemistry, 2023-03, Vol.66 (6), p.3852-3865

2023

Volltextzugriff (PDF)

Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice

Blood, 2020-05, Vol.135 (20), p.1772-1782

2020

Volltextzugriff (PDF)

Chemical proteomic analysis of palmostatin beta-lactone analogs that affect N-Ras palmitoylation

Bioorganic & medicinal chemistry letters, 2021-12, Vol.53, p.128414-128414, Article 128414

2021

Volltextzugriff (PDF)

Type Iγ phosphatidylinositol phosphate kinase targets and regulates focal adhesions

Nature (London), 2002-11, Vol.420 (6911), p.89-93

2002

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Type Iγ661 Phosphatidylinositol Phosphate Kinase Directly Interacts with AP2 and Regulates Endocytosis

The Journal of biological chemistry, 2006-07, Vol.281 (29), p.20632-20642

2006

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Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent

Developmental biology, 2009-04, Vol.328 (2), p.342-354

2009

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Abstract B43: Requirement for PI3 kinase interaction in K-RasG12D-driven leukemogenesis

Clinical cancer research, 2015-09, Vol.21 (17_Supplement), p.B43-B43

2015

Volltextzugriff (PDF)

Abstract A23: A second site KrasG12D mutation that impairs PI3K binding rescues embryonic lethality, abrogates myeloproliferative disease, and delays lung tumorigenesis

Molecular cancer research, 2020-05, Vol.18 (5_Supplement), p.A23-A23

2020

Volltextzugriff (PDF)

Abstract A25: In vivo evidence validating the palmitoylation/depalmitoylation cycle as a therapeutic target in NRAS mutant hematologic cancers

Molecular cancer research, 2020-05, Vol.18 (5_Supplement), p.A25-A25

2020

Volltextzugriff (PDF)

Genetic Validation of the Palmitoylation/Depalmitoylation Cycle As a Drug Target in NRAS Mutant Hematologic Malignancies In Vivo

Blood, 2017-12, Vol.130, p.1221-1221

2017

Volltextzugriff (PDF)

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Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein

ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth

Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance

Preclinical efficacy of MEK inhibition in Nras-mutant AML

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers

Controlling Destiny through Chemistry: Small-Molecule Regulators of Cell Fate

Monoallelic loss of the imprinted gene Grb10 promotes tumor formation in irradiated Nf1+/- mice

Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation

KRAS insertion mutations are oncogenic and exhibit distinct functional properties

Arhgap36-dependent activation of Gli transcription factors

Correction: Monoallelic Loss of the Imprinted Gene Grb10 Promotes Tumor Formation in Irradiated Nf1+/- Mice

A three-drug combination to treat BRAF-mutant cancers

KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer

Imidazopyridine Derivative JK184 Reveals Dual Roles for Microtubules in Hedgehog Signaling

Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo

Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice

Chemical proteomic analysis of palmostatin beta-lactone analogs that affect N-Ras palmitoylation

Type Iγ phosphatidylinositol phosphate kinase targets and regulates focal adhesions

Type Iγ661 Phosphatidylinositol Phosphate Kinase Directly Interacts with AP2 and Regulates Endocytosis

Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent

Abstract B43: Requirement for PI3 kinase interaction in K-RasG12D-driven leukemogenesis

Abstract A23: A second site KrasG12D mutation that impairs PI3K binding rescues embryonic lethality, abrogates myeloproliferative disease, and delays lung tumorigenesis

Abstract A25: In vivo evidence validating the palmitoylation/depalmitoylation cycle as a therapeutic target in NRAS mutant hematologic cancers

Genetic Validation of the Palmitoylation/Depalmitoylation Cycle As a Drug Target in NRAS Mutant Hematologic Malignancies In Vivo

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