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Targeting TRAIL in the treatment of cancer: new developments

Expert opinion on therapeutic targets, 2015-09, Vol.19 (9), p.1171-1185

2015

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Application of 3D tumoroid systems to define immune and cytotoxic therapeutic responses based on tumoroid and tissue slice culture molecular signatures

Oncotarget, 2017-09, Vol.8 (40), p.66747-66757

2017

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Sorafenib and Quinacrine Target Anti-Apoptotic Protein MCL1: A Poor Prognostic Marker in Anaplastic Thyroid Cancer (ATC)

Clinical cancer research, 2016-12, Vol.22 (24), p.6192-6203

2016

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Occurrence of acute myeloid leukemia in hydroxyurea-treated sickle cell disease patient

Cancer biology & therapy, 2019-11, Vol.20 (11), p.1389-1397

2019

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P53 represses pyrimidine catabolic gene dihydropyrimidine dehydrogenase (DPYD) expression in response to thymidylate synthase (TS) targeting

Scientific reports, 2017-08, Vol.7 (1), p.9711-12, Article 9711

2017

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Agonists of the TRAIL Death Receptor DR5 Sensitize Intestinal Stem Cells to Chemotherapy-Induced Cell Death and Trigger Gastrointestinal Toxicity

Cancer research (Chicago, Ill.), 2016-02, Vol.76 (3), p.700-712

2016

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The relative contribution of pro-apoptotic p53-target genes in the triggering of apoptosis following DNA damage in vitro and in vivo

Cell cycle (Georgetown, Tex.), 2011-07, Vol.10 (14), p.2380-2389

2011

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Death Receptor 5 Signaling Promotes Hepatocyte Lipoapoptosis

The Journal of biological chemistry, 2011-11, Vol.286 (45), p.39336-39348

2011

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Tissue TGF-β expression following conventional radiotherapy and pulsed low-dose-rate radiation

Cell cycle (Georgetown, Tex.), 2017-06, Vol.16 (12), p.1171-1174

2017

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Targeting of Chk2 as a countermeasure to dose-limiting toxicity triggered by topoisomerase-II (TOP2) poisons

Oncotarget, 2016-05, Vol.7 (20), p.29520-29530

2016

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Detection of DSS-induced gastrointestinal mucositis in mice by non-invasive optical near-infrared (NIR) imaging of cathepsin activity

Cancer biology & therapy, 2013-08, Vol.14 (8), p.736-741

2013

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TRAIL death receptors as tumor suppressors and drug targets

Cell cycle (Georgetown, Tex.), 2008-06, Vol.7 (11), p.1525-1528

2008

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Oral administration of TRAIL-inducing small molecule ONC201/TIC10 prevents intestinal polyposis in the Apcmin/+ mouse model

American journal of cancer research, 2022-05, Vol.12 (5), p.2118-2131

2022

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Preliminary observations indicate variable patterns of plasma 5-fluorouracil (5-FU) levels during dose optimization of infusional 5-FU in colorectal cancer patients

Cancer biology & therapy, 2011-10, Vol.12 (7), p.557-568

2011

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Gamma-radiation (GR) triggers a unique gene expression profile associated with cell death compared to proton radiation (PR) in mice in vivo

Cancer biology & therapy, 2008-12, Vol.7 (12), p.2023-2033

2008

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PIGN gene expression aberration is associated with genomic instability and leukemic progression in acute myeloid leukemia with myelodysplastic features

Oncotarget, 2017-05, Vol.8 (18), p.29887-29905

2017

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DR5 Knockout Mice Are Compromised in Radiation-Induced Apoptosis

Molecular and Cellular Biology, 2005-03, Vol.25 (5), p.2000-2013

2005

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Protective Effects of Dietary Antioxidants on Proton Total-Body Irradiation-Mediated Hematopoietic Cell and Animal Survival

Radiation research, 2009-08, Vol.172 (2), p.175-186

2009

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ANIMAL MODELS OF CANCER BIOLOGY

Cancer Growth and Metastasis, 2015-01, Vol.8s1 (Suppl 1), p.115-118

2015

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High-Resolution Imaging and Antitumor Effects of GFP+ Bone Marrow-Derived Cells Homing to Syngeneic Mouse Colon Tumors

The American journal of pathology, 2011-11, Vol.179 (5), p.2169-2176

2011

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Reduced cell death, invasive and angiogenic features conferred by BRCA1-deficiency in mammary epithelial cells transformed with H-Ras

Cancer biology & therapy, 2009-12, Vol.8 (24), p.2417-2444

2009

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ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosis

The Journal of clinical investigation, 2014-06, Vol.124 (6), p.2626-2639

2014

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Abstract 1866: Small molecule NSC59984 is a radio-sensitizer dependent on ERK2 and DDR but independent of wild-type p53

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.1866-1866

2018

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Abstract 96: Didhydropyrimdine dehydrogenase (DPYD) provides resistance to 5-flurouracil in mutant p53 (mtp53) expressing colorectal cancer cells

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.96-96

2017

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Abstract 5636: Targeting of NOXA overexpression in anaplastic thyroid cancer (ATC)

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.5636-5636

2017

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Targeting TRAIL in the treatment of cancer: new developments

Application of 3D tumoroid systems to define immune and cytotoxic therapeutic responses based on tumoroid and tissue slice culture molecular signatures

Sorafenib and Quinacrine Target Anti-Apoptotic Protein MCL1: A Poor Prognostic Marker in Anaplastic Thyroid Cancer (ATC)

Occurrence of acute myeloid leukemia in hydroxyurea-treated sickle cell disease patient

P53 represses pyrimidine catabolic gene dihydropyrimidine dehydrogenase (DPYD) expression in response to thymidylate synthase (TS) targeting

Agonists of the TRAIL Death Receptor DR5 Sensitize Intestinal Stem Cells to Chemotherapy-Induced Cell Death and Trigger Gastrointestinal Toxicity

The relative contribution of pro-apoptotic p53-target genes in the triggering of apoptosis following DNA damage in vitro and in vivo

Death Receptor 5 Signaling Promotes Hepatocyte Lipoapoptosis

Tissue TGF-β expression following conventional radiotherapy and pulsed low-dose-rate radiation

Targeting of Chk2 as a countermeasure to dose-limiting toxicity triggered by topoisomerase-II (TOP2) poisons

Detection of DSS-induced gastrointestinal mucositis in mice by non-invasive optical near-infrared (NIR) imaging of cathepsin activity

TRAIL death receptors as tumor suppressors and drug targets

Oral administration of TRAIL-inducing small molecule ONC201/TIC10 prevents intestinal polyposis in the Apcmin/+ mouse model

Preliminary observations indicate variable patterns of plasma 5-fluorouracil (5-FU) levels during dose optimization of infusional 5-FU in colorectal cancer patients

Gamma-radiation (GR) triggers a unique gene expression profile associated with cell death compared to proton radiation (PR) in mice in vivo

PIGN gene expression aberration is associated with genomic instability and leukemic progression in acute myeloid leukemia with myelodysplastic features

DR5 Knockout Mice Are Compromised in Radiation-Induced Apoptosis

Protective Effects of Dietary Antioxidants on Proton Total-Body Irradiation-Mediated Hematopoietic Cell and Animal Survival

ANIMAL MODELS OF CANCER BIOLOGY

High-Resolution Imaging and Antitumor Effects of GFP+ Bone Marrow-Derived Cells Homing to Syngeneic Mouse Colon Tumors

Reduced cell death, invasive and angiogenic features conferred by BRCA1-deficiency in mammary epithelial cells transformed with H-Ras

ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosis

Abstract 1866: Small molecule NSC59984 is a radio-sensitizer dependent on ERK2 and DDR but independent of wild-type p53

Abstract 96: Didhydropyrimdine dehydrogenase (DPYD) provides resistance to 5-flurouracil in mutant p53 (mtp53) expressing colorectal cancer cells

Abstract 5636: Targeting of NOXA overexpression in anaplastic thyroid cancer (ATC)

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