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Polyreactivity and polyspecificity in therapeutic antibody development: risk factors for failure in preclinical and clinical development campaigns

mAbs, 2021-01, Vol.13 (1), p.1999195-1999195

2021

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Anti-PD1 'SHR-1210' aberrantly targets pro-angiogenic receptors and this polyspecificity can be ablated by paratope refinement

mAbs, 2019-01, Vol.11 (1), p.26-44

2019

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Synthetic Antibodies Designed on Natural Sequence Landscapes

Journal of molecular biology, 2011-09, Vol.412 (1), p.55-71

2011

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Phage Display: A Powerful Technology for the Generation of High-Specificity Affinity Reagents from Alternative Immune Sources

Methods in molecular biology (Clifton, N.J.), 2017-01, Vol.1485, p.85

2017

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Optimized Generation of High-Affinity, High-Specificity Single-Chain Fv Antibodies from Multi-Antigen Immunized Chickens

Methods in molecular biology (Clifton, N.J.), 2017, Vol.1485, p.319

2017

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Natural and man-made V-gene repertoires for antibody discovery

Frontiers in immunology, 2012-01, Vol.3, p.342-342

2012

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Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics

mAbs, 2018-02, Vol.10 (2), p.244-255

2018

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Comprehensive Interrogation of a Minimalist Synthetic CDR-H3 Library and Its Ability to Generate Antibodies with Therapeutic Potential

Journal of molecular biology, 2013-05, Vol.425 (10), p.1712-1730

2013

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De novo discovery of antibody drugs - great promise demands scrutiny

mAbs, 2019-07, Vol.11 (5), p.809-811

2019

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An Ultra-specific Avian Antibody to Phosphorylated Tau Protein Reveals a Unique Mechanism for Phosphoepitope Recognition

The Journal of biological chemistry, 2012-12, Vol.287 (53), p.44425-44434

2012

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High Tech and High Touch: Headhunting, Technology, and Economic Transformation

1, 2017

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A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv)

The Journal of biological chemistry, 2016-01, Vol.291 (3), p.1267-1276

2016

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Anthropocene climate bifurcation

Nonlinear processes in geophysics, 2020-07, Vol.27 (3), p.391-409

2020

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Headhunters: Matchmaking in the Labor Market

wit, 2018

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A high-affinity recombinant antibody permits rapid and sensitive direct detection of myeloperoxidase

Analytical biochemistry, 2011-03, Vol.410 (1), p.1-6

2011

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Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies

Proceedings of the National Academy of Sciences - PNAS, 2015-12, Vol.112 (50), p.15354-15359

2015

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Increased Serum Levels of Complement C3a Anaphylatoxin Indicate the Presence of Colorectal Tumors

Gastroenterology (New York, N.Y. 1943), 2006-10, Vol.131 (4), p.1020-1029

2006

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In vitro affinity optimization of an anti-BDNF monoclonal antibody translates to improved potency in targeting chronic pain states in vivo

mAbs, 2020-01, Vol.12 (1), p.1755000-1755000

2020

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Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer

Antibodies (Basel), 2016-03, Vol.5 (1), p.6

2016

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High throughput ranking of recombinant avian scFv antibody fragments from crude lysates using the Biacore A100

Journal of immunological methods, 2007-06, Vol.323 (2), p.172-179

2007

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Phage display: a powerful technology for the generation of high specificity affinity reagents from alternative immune sources

Methods in molecular biology (Clifton, N.J.), 2011-01, Vol.681, p.87

2011

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Developing cell-specific antibodies to endothelial progenitor cells using avian immune phage display technology

Journal of biomolecular screening, 2011-08, Vol.16 (7), p.744-754

2011

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Optimized generation of high-affinity, high-specificity single-chain Fv antibodies from multiantigen immunized chickens

Methods in molecular biology (Clifton, N.J.), 2011, Vol.681, p.383

2011

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Fundamental characteristics of the immunoglobulin VH repertoire of chickens in comparison with those of humans, mice, and camelids

The Journal of immunology (1950), 2012-01, Vol.188 (1), p.322-333

2012

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Polyreactivity and polyspecificity in therapeutic antibody development: risk factors for failure in preclinical and clinical development campaigns

Anti-PD1 'SHR-1210' aberrantly targets pro-angiogenic receptors and this polyspecificity can be ablated by paratope refinement

Synthetic Antibodies Designed on Natural Sequence Landscapes

Phage Display: A Powerful Technology for the Generation of High-Specificity Affinity Reagents from Alternative Immune Sources

Optimized Generation of High-Affinity, High-Specificity Single-Chain Fv Antibodies from Multi-Antigen Immunized Chickens

Natural and man-made V-gene repertoires for antibody discovery

Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics

Comprehensive Interrogation of a Minimalist Synthetic CDR-H3 Library and Its Ability to Generate Antibodies with Therapeutic Potential

De novo discovery of antibody drugs - great promise demands scrutiny

An Ultra-specific Avian Antibody to Phosphorylated Tau Protein Reveals a Unique Mechanism for Phosphoepitope Recognition

High Tech and High Touch: Headhunting, Technology, and Economic Transformation

A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv)

Anthropocene climate bifurcation

Headhunters: Matchmaking in the Labor Market

A high-affinity recombinant antibody permits rapid and sensitive direct detection of myeloperoxidase

Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies

Increased Serum Levels of Complement C3a Anaphylatoxin Indicate the Presence of Colorectal Tumors

CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery

In vitro affinity optimization of an anti-BDNF monoclonal antibody translates to improved potency in targeting chronic pain states in vivo

Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer

High throughput ranking of recombinant avian scFv antibody fragments from crude lysates using the Biacore A100

Phage display: a powerful technology for the generation of high specificity affinity reagents from alternative immune sources

Developing cell-specific antibodies to endothelial progenitor cells using avian immune phage display technology

Optimized generation of high-affinity, high-specificity single-chain Fv antibodies from multiantigen immunized chickens

Fundamental characteristics of the immunoglobulin VH repertoire of chickens in comparison with those of humans, mice, and camelids

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