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Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions

Molecular cancer therapeutics, 2018-05, Vol.17 (5), p.885-896

2018

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Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy

The Journal of clinical investigation, 2020-01, Vol.130 (1), p.258-271

2020

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AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer

Cancer discovery, 2014-09, Vol.4 (9), p.1046-1061

2014

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Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR)

Journal of medicinal chemistry, 2013-09, Vol.56 (17), p.7025-7048

2013

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The Discovery of 7‑Methyl-2-[(7-methyl[1,2,4]triazolo[1,5‑a]pyridin-6-yl)amino]-9-(tetrahydro‑2H‑pyran-4-yl)-7,9-dihydro‑8H‑purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor

Journal of medicinal chemistry, 2020-04, Vol.63 (7), p.3461-3471

2020

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Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family

Bioorganic & medicinal chemistry letters, 2012-09, Vol.22 (17), p.5352-5359

2012

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Low genetic diversity and potential inbreeding in an isolated population of alder buckthorn (Frangula alnus) following a founder effect

Scientific reports, 2017-06, Vol.7 (1), p.3010-8, Article 3010

2017

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Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor

Journal of medicinal chemistry, 2014-10, Vol.57 (20), p.8249-8267

2014

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Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation

Journal of medicinal chemistry, 2015-03, Vol.58 (5), p.2265-2274

2015

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Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S-Mediated Resistance

Journal of medicinal chemistry, 2021-09, Vol.64 (18), p.13704-13718

2021

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Sulfonyl-morpholino-pyrimidines: SAR and development of a novel class of selective mTOR kinase inhibitor

Bioorganic & medicinal chemistry letters, 2012-06, Vol.22 (12), p.4163-4168

2012

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Imidazole pyrimidine amides as potent, orally bioavailable cyclin-dependent kinase inhibitors

Bioorganic & medicinal chemistry, 2008-12, Vol.18 (24), p.6486-6489

2008

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The structure-guided discovery of osimertinib: the first U.S. FDA approved mutant selective inhibitor of EGFR T790M

MedChemComm, 2017-05, Vol.8 (5), p.820-822

2017

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DNA-dependent protein kinase (DNA-PK) inhibitors: Structure–activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain

Bioorganic & medicinal chemistry letters, 2011-02, Vol.21 (3), p.966-970

2011

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Enhancing the clinical utility of the Burn Specific Health Scale-Brief: Not just for major burns

Burns, 2014-03, Vol.40 (2), p.328-336

2014

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Towards more efficient burn care: Identifying factors associated with good quality of life post-burn

Burns, 2015-11, Vol.41 (7), p.1397-1404

2015

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AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity

Nature communications, 2019-11, Vol.10 (1), p.5065-15, Article 5065

2019

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Imidazole piperazines: SAR and development of a potent class of cyclin-dependent kinase inhibitors with a novel binding mode

Bioorganic & medicinal chemistry, 2008-08, Vol.18 (15), p.4442-4446

2008

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Discovery of AZD3147: A Potent, Selective Dual Inhibitor of mTORC1 and mTORC2

Journal of medicinal chemistry, 2015-03, Vol.58 (5), p.2326-2349

2015

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Total Syntheses of Epothilones A and B via a Macrolactonization-Based Strategy

Journal of the American Chemical Society, 1997-08, Vol.119 (34), p.7974-7991

1997

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Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors

Bioorganic & medicinal chemistry, 2008-10, Vol.18 (20), p.5487-5492

2008

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Measurement of localized tissue water – clinical application of bioimpedance spectroscopy in wound management

Journal of physics. Conference series, 2013-01, Vol.434 (1), p.12043-4

2013

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A review of camera trapping for conservation behaviour research

Remote sensing in ecology and conservation, 2017-09, Vol.3 (3), p.109-122

2017

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Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions

Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy

AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer

Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR)

The Discovery of 7‑Methyl-2-[(7-methyl[1,2,4]triazolo[1,5‑a]pyridin-6-yl)amino]-9-(tetrahydro‑2H‑pyran-4-yl)-7,9-dihydro‑8H‑purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor

Preclinical Comparison of the Blood-brain barrier Permeability of Osimertinib with Other EGFR TKIs

Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family

Low genetic diversity and potential inbreeding in an isolated population of alder buckthorn (Frangula alnus) following a founder effect

Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor

Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation

Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S-Mediated Resistance

Sulfonyl-morpholino-pyrimidines: SAR and development of a novel class of selective mTOR kinase inhibitor

Imidazole pyrimidine amides as potent, orally bioavailable cyclin-dependent kinase inhibitors

The structure-guided discovery of osimertinib: the first U.S. FDA approved mutant selective inhibitor of EGFR T790M

DNA-dependent protein kinase (DNA-PK) inhibitors: Structure–activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain

Enhancing the clinical utility of the Burn Specific Health Scale-Brief: Not just for major burns

Discovery of a Thiadiazole–Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models

Towards more efficient burn care: Identifying factors associated with good quality of life post-burn

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity

Imidazole piperazines: SAR and development of a potent class of cyclin-dependent kinase inhibitors with a novel binding mode

Discovery of AZD3147: A Potent, Selective Dual Inhibitor of mTORC1 and mTORC2

Total Syntheses of Epothilones A and B via a Macrolactonization-Based Strategy

Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors

Measurement of localized tissue water – clinical application of bioimpedance spectroscopy in wound management

A review of camera trapping for conservation behaviour research

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