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Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy

The Journal of clinical investigation, 2020-01, Vol.130 (1), p.258-271

2020

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AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity

Nature communications, 2019-11, Vol.10 (1), p.5065-15, Article 5065

2019

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Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions

Molecular cancer therapeutics, 2018-05, Vol.17 (5), p.885-896

2018

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The Discovery of 7‑Methyl-2-[(7-methyl[1,2,4]triazolo[1,5‑a]pyridin-6-yl)amino]-9-(tetrahydro‑2H‑pyran-4-yl)-7,9-dihydro‑8H‑purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor

Journal of medicinal chemistry, 2020-04, Vol.63 (7), p.3461-3471

2020

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Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor

Journal of medicinal chemistry, 2014-10, Vol.57 (20), p.8249-8267

2014

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Feedbacks between sea-floor spreading, trade winds and precipitation in the Southern Red Sea

Nature communications, 2022-09, Vol.13 (1), p.5405-5405, Article 5405

2022

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Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR)

Journal of medicinal chemistry, 2013-09, Vol.56 (17), p.7025-7048

2013

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Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S-Mediated Resistance

Journal of medicinal chemistry, 2021-09, Vol.64 (18), p.13704-13718

2021

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Alcohol Use and Mental Health among Older American Adults during the Early Months of the COVID-19 Pandemic

International journal of environmental research and public health, 2021-04, Vol.18 (8), p.4222

2021

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Induction of regulatory cells by helminth parasites: exploitation for the treatment of inflammatory diseases

Immunological reviews, 2014-05, Vol.259 (1), p.206-230

2014

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Divergent Roles for the IL-1 Family in Gastrointestinal Homeostasis and Inflammation

Frontiers in immunology, 2019-06, Vol.10, p.1266-1266

2019

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Improving breeding efficiency in potato using molecular and quantitative genetics

Theoretical and applied genetics, 2014-11, Vol.127 (11), p.2279-2292

2014

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Formation of hybrid arc andesites beneath thick continental crust

Earth and planetary science letters, 2011-03, Vol.303 (3-4), p.337-347

2011

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The role of mantle melting in granite-associated hydrothermal systems: He–Ar isotopes in fluids responsible for Sn–Ag–Pb–Zn mineralization in northeast China

Mineralium deposita, 2023-11, Vol.58 (8), p.1421-1443

2023

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Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease

Nature communications, 2017-12, Vol.8 (1), p.1923-11, Article 1923

2017

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Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation

Journal of medicinal chemistry, 2015-03, Vol.58 (5), p.2265-2274

2015

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Association between temperature exposure and cognition: a cross-sectional analysis of 20,687 aging adults in the United States

BMC public health, 2021-07, Vol.21 (1), p.1484-12, Article 1484

2021

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Cohort profile: the COVID-19 Coping Study, a longitudinal mixed-methods study of middle-aged and older adults’ mental health and well-being during the COVID-19 pandemic in the USA

BMJ open, 2021-02, Vol.11 (2), p.e044965-e044965

2021

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Neogene fluvial landscape evolution in the hyperarid core of the Atacama Desert

Scientific reports, 2018-09, Vol.8 (1), p.13952-16, Article 13952

2018

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Late Cretaceous to Late Eocene Exhumation in the Nima Area, Central Tibet: Implications for Development of Low Relief Topography of the Tibetan Plateau

Tectonics (Washington, D.C.), 2022-03, Vol.41 (3), p.n/a

2022

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‘Walk like a penguin’: Older Minnesotans' experiences of (non)therapeutic white space

Social science & medicine (1982), 2018-02, Vol.198, p.77-84

Finlay, Jessica M.

2018

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Synthesis and Reactivity of Acyclic Germanimines: Silyl Rearrangement and Cycloadditions

Inorganic chemistry, 2021-06, Vol.60 (11), p.8293-8303

2021

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Impact of CaSO4-rich soil on Miocene surface preservation and Quaternary sinuous to meandering channel forms in the hyperarid Atacama Desert

Scientific reports, 2022-10, Vol.12 (1), p.17951-17951, Article 17951

2022

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Preclinical Comparison of the Blood-brain barrier Permeability of Osimertinib with Other EGFR TKIs

Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity

Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions

The Discovery of 7‑Methyl-2-[(7-methyl[1,2,4]triazolo[1,5‑a]pyridin-6-yl)amino]-9-(tetrahydro‑2H‑pyran-4-yl)-7,9-dihydro‑8H‑purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor

Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor

Feedbacks between sea-floor spreading, trade winds and precipitation in the Southern Red Sea

Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR)

Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S-Mediated Resistance

Alcohol Use and Mental Health among Older American Adults during the Early Months of the COVID-19 Pandemic

Induction of regulatory cells by helminth parasites: exploitation for the treatment of inflammatory diseases

AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer

Divergent Roles for the IL-1 Family in Gastrointestinal Homeostasis and Inflammation

Improving breeding efficiency in potato using molecular and quantitative genetics

Formation of hybrid arc andesites beneath thick continental crust

The role of mantle melting in granite-associated hydrothermal systems: He–Ar isotopes in fluids responsible for Sn–Ag–Pb–Zn mineralization in northeast China

Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease

Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation

Association between temperature exposure and cognition: a cross-sectional analysis of 20,687 aging adults in the United States

Cohort profile: the COVID-19 Coping Study, a longitudinal mixed-methods study of middle-aged and older adults’ mental health and well-being during the COVID-19 pandemic in the USA

Neogene fluvial landscape evolution in the hyperarid core of the Atacama Desert

Late Cretaceous to Late Eocene Exhumation in the Nima Area, Central Tibet: Implications for Development of Low Relief Topography of the Tibetan Plateau

‘Walk like a penguin’: Older Minnesotans' experiences of (non)therapeutic white space

Synthesis and Reactivity of Acyclic Germanimines: Silyl Rearrangement and Cycloadditions

Impact of CaSO4-rich soil on Miocene surface preservation and Quaternary sinuous to meandering channel forms in the hyperarid Atacama Desert

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