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Structure−Activity Relationships for Substituted Bis(acridine-4-carboxamides): A New Class of Anticancer Agents

Journal of medicinal chemistry, 1999-07, Vol.42 (13), p.2383-2393

1999

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Synthesis and Cytotoxic Activity of 7-Oxo-7H-dibenz[f , i j]isoquinoline and 7-Oxo-7H-benzo[e]perimidine Derivatives

Journal of medicinal chemistry, 2001-06, Vol.44 (12), p.2004-2014

2001

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From amsacrine to DACA (N-[2-(dimethylamino)ethyl]acridine-4-carboxamide): Selectivity for topoisomerases I and II among acridine derivatives

European journal of cancer (1990), 1996-04, Vol.32 (4), p.708-714

1996

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Bis(phenazine-1-carboxamides): Structure−Activity Relationships for a New Class of Dual Topoisomerase I/II-Directed Anticancer Drugs

Journal of medicinal chemistry, 2000-04, Vol.43 (7), p.1350-1358

2000

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Synthesis and antitumor activity of some indeno[1,2-b]quinoline-based bis carboxamides

Bioorganic & medicinal chemistry, 2000-05, Vol.8 (5), p.977-984

2000

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Synthesis and Antitumor Properties of N-[2-(Dimethylamino)ethyl]carboxamide Derivatives of Fused Tetracyclic Quinolines and Quinoxalines: A New Class of Putative Topoisomerase Inhibitors

Journal of medicinal chemistry, 1997-06, Vol.40 (13), p.2040-2046

1997

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Dicationic Bis(9-methylphenazine-1-carboxamides): Relationships between Biological Activity and Linker Chain Structure for a Series of Potent Topoisomerase Targeted Anticancer Drugs

Journal of medicinal chemistry, 2001-04, Vol.44 (9), p.1407-1415

2001

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Structure−Activity Relationships for Acridine-Substituted Analogues of the Mixed Topoisomerase I/II Inhibitor N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide

Journal of medicinal chemistry, 1997-06, Vol.40 (12), p.1919-1929

1997

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Effects of protein binding on the in vitro activity of antitumour acridine derivatives and related anticancer drugs

Cancer chemotherapy and pharmacology, 2000, Vol.45 (5), p.417-422

2000

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Ring-substituted 11-oxo-11H-indeno[1,2-b]quinoline-6-carboxamides with similar patterns of cytotoxicity to the dual topo I/II inhibitor DACA

Bioorganic & medicinal chemistry, 1999-12, Vol.7 (12), p.2801-2809

1999

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Genotypic and environmental variation in grain, flour, dough and bread-making characteristics of western Canadian spring wheat

Canadian journal of plant science, 2007-10, Vol.87 (4), p.679-690

2007

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Cellular responses to methyl- N-[4-(9-acridinylamino)-2-methoxyphenyl]carbamate hydrochloride, an analogue of amsacrine active against non-proliferating cells

European journal of cancer (1990), 1997-09, Vol.33 (10), p.1668-1676

1997

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Multiple Patterns of Resistance of Human Leukemia Cell Sublines to Amsacrine Analogues

JNCI : Journal of the National Cancer Institute, 1990-04, Vol.82 (8), p.662-667

1990

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A carbamate analogue of amsacrine with activity against non-cycling cells stimulates topoisomerase ii cleavage at dna sites distinct from those of amsacrine

European journal of cancer (1990), 1997-02, Vol.33 (2), p.272-279

1997

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Melphalan penetration of the blood-brain barrier via the neutral amino acid transporter in tumor-bearing brain

Cancer research (Chicago, Ill.), 1992, Vol.52 (1), p.138-143

1992

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Synthesis and cytotoxic activity of carboxamide derivatives of benzimidazo[2,1-a]isoquinoline and pyrido[3',2':4,5]imidazo[2,1-a]isoquinoline

Anti-cancer drug design, 2000-10, Vol.15 (5), p.339

2000

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Microculture-Based Chemosensitivity Testing: A Feasibility Study Comparing Freshly Explanted Human Melanoma Cells With Human Melanoma Cell Lines

JNCI : Journal of the National Cancer Institute, 1992-03, Vol.84 (5), p.340-345

1992

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P12.02 Glioblastoma Multiforme immunological blockades and the implications of glioma cancer stem cells

Neuro-oncology (Charlottesville, Va.), 2019-09, Vol.21 (Supplement_3), p.iii59-iii59

2019

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Inhibition of the action of the topoisomerase II poison amsacrine by simple aniline derivatives: evidence for drug-protein interactions

Oncology research, 1999, Vol.11 (6), p.249

1999

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Differential actions of aclarubicin and doxorubicin: the role of topoisomerase I

Oncology research, 1997, Vol.9 (10), p.535

1997

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Positioning of the carboxamide side chain in 11-oxo-11H-indeno[1,2-b]quinolinecarboxamide anticancer agents : Effects on cytotoxicity

Bioorganic & medicinal chemistry, 2001-02, Vol.9 (2), p.445-452

2001

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Cytotoxicity of salicylaldehyde benzoylhydrazone analogs and their transition metal complexes: quantitative structure–activity relationships

Journal of inorganic biochemistry, 1999-11, Vol.77 (3), p.125-133

1999

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Resistance mechanisms determining the in vitro sensitivity to paclitaxel of tumour cells cultured from patients with ovarian cancer

European journal of cancer (1990), 1995, Vol.31 (2), p.230-237

1995

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Radiosensitivity of new and established human melanoma cell lines: Comparison of [ 3H]thymidine incorporation and soft agar clonogenic assays

European journal of cancer (1990), 1994, Vol.30 (9), p.1370-1376

1994

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Subcellular distribution and photocytotoxicity of aluminium phthalocyanines and haematoporphyrin derivative in cultured human meningioma cells

British journal of neurosurgery, 1996, Vol.10 (1), p.51-57

MALHAM, G. M.

1996

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Structure−Activity Relationships for Substituted Bis(acridine-4-carboxamides): A New Class of Anticancer Agents

Synthesis and Cytotoxic Activity of 7-Oxo-7H-dibenz[f , i j]isoquinoline and 7-Oxo-7H-benzo[e]perimidine Derivatives

From amsacrine to DACA (N-[2-(dimethylamino)ethyl]acridine-4-carboxamide): Selectivity for topoisomerases I and II among acridine derivatives

Bis(phenazine-1-carboxamides): Structure−Activity Relationships for a New Class of Dual Topoisomerase I/II-Directed Anticancer Drugs

Synthesis and antitumor activity of some indeno[1,2-b]quinoline-based bis carboxamides

Synthesis and Antitumor Properties of N-[2-(Dimethylamino)ethyl]carboxamide Derivatives of Fused Tetracyclic Quinolines and Quinoxalines: A New Class of Putative Topoisomerase Inhibitors

Dicationic Bis(9-methylphenazine-1-carboxamides): Relationships between Biological Activity and Linker Chain Structure for a Series of Potent Topoisomerase Targeted Anticancer Drugs

Structure−Activity Relationships for Acridine-Substituted Analogues of the Mixed Topoisomerase I/II Inhibitor N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide

Effects of protein binding on the in vitro activity of antitumour acridine derivatives and related anticancer drugs

Ring-substituted 11-oxo-11H-indeno[1,2-b]quinoline-6-carboxamides with similar patterns of cytotoxicity to the dual topo I/II inhibitor DACA

Genotypic and environmental variation in grain, flour, dough and bread-making characteristics of western Canadian spring wheat

Cellular responses to methyl- N-[4-(9-acridinylamino)-2-methoxyphenyl]carbamate hydrochloride, an analogue of amsacrine active against non-proliferating cells

Multiple Patterns of Resistance of Human Leukemia Cell Sublines to Amsacrine Analogues

A carbamate analogue of amsacrine with activity against non-cycling cells stimulates topoisomerase ii cleavage at dna sites distinct from those of amsacrine

Melphalan penetration of the blood-brain barrier via the neutral amino acid transporter in tumor-bearing brain

Synthesis and cytotoxic activity of carboxamide derivatives of benzimidazo[2,1-a]isoquinoline and pyrido[3',2':4,5]imidazo[2,1-a]isoquinoline

Microculture-Based Chemosensitivity Testing: A Feasibility Study Comparing Freshly Explanted Human Melanoma Cells With Human Melanoma Cell Lines

P12.02 Glioblastoma Multiforme immunological blockades and the implications of glioma cancer stem cells

Inhibition of the action of the topoisomerase II poison amsacrine by simple aniline derivatives: evidence for drug-protein interactions

Differential actions of aclarubicin and doxorubicin: the role of topoisomerase I

Positioning of the carboxamide side chain in 11-oxo-11H-indeno[1,2-b]quinolinecarboxamide anticancer agents : Effects on cytotoxicity

Cytotoxicity of salicylaldehyde benzoylhydrazone analogs and their transition metal complexes: quantitative structure–activity relationships

Resistance mechanisms determining the in vitro sensitivity to paclitaxel of tumour cells cultured from patients with ovarian cancer

Radiosensitivity of new and established human melanoma cell lines: Comparison of [ 3H]thymidine incorporation and soft agar clonogenic assays

Subcellular distribution and photocytotoxicity of aluminium phthalocyanines and haematoporphyrin derivative in cultured human meningioma cells

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