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Biased agonism at the cannabinoid receptors – Evidence from synthetic cannabinoid receptor agonists

Cellular signalling, 2021-02, Vol.78, p.109865, Article 109865

2021

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Terpenoids From Cannabis Do Not Mediate an Entourage Effect by Acting at Cannabinoid Receptors

Frontiers in pharmacology, 2020-03, Vol.11, p.359-359

2020

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Cannabinoid CB1 and CB2 Receptor-Mediated Arrestin Translocation: Species, Subtype, and Agonist-Dependence

Frontiers in pharmacology, 2019-04, Vol.10, p.350-350

2019

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GPR18 undergoes a high degree of constitutive trafficking but is unresponsive to N-Arachidonoyl Glycine

PeerJ (San Francisco, CA), 2016-03, Vol.4, p.e1835-e1835, Article e1835

2016

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Determination of the Cannabinoid CB1 Receptor's Positive Allosteric Modulator Binding Site through Mutagenesis Studies

Pharmaceuticals (Basel, Switzerland), 2024-01, Vol.17 (2), p.154

2024

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100 years of modelling ligand–receptor binding and response: A focus on GPCRs

British journal of pharmacology, 2020-04, Vol.177 (7), p.1472-1484

2020

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Evaluating signaling bias for synthetic cannabinoid receptor agonists at the cannabinoid CB2 receptor

Pharmacology research & perspectives, 2023-12, Vol.11 (6), p.e01157-n/a

2023

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Characterisation of AMB-FUBINACA metabolism and CB1-mediated activity of its acid metabolite

Forensic toxicology, 2023-01, Vol.41 (1), p.114-125

2023

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GPCR kinase subtype requirements for arrestin-2 and -3 translocation to the cannabinoid CB1 receptor and the consequences on G protein signalling

Biochemical pharmacology, 2024-06, Vol.224, p.116190, Article 116190

2024

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Cannabinoid 1 (CB1) receptor arrestin subtype‐selectivity and phosphorylation dependence

British journal of pharmacology, 2023-02, Vol.180 (3), p.369-382

2023

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Model‐free and kinetic modelling approaches for characterising non‐equilibrium pharmacological pathway activity: Internalisation of cannabinoid CB1 receptors

British journal of pharmacology, 2019-07, Vol.176 (14), p.2593-2607

2019

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Investigating selectivity and bias for G protein subtypes and β-arrestins by synthetic cannabinoid receptor agonists at the cannabinoid CB1 receptor

Biochemical pharmacology, 2024-04, Vol.222, p.116052, Article 116052

2024

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Evaluation of the profiles of CB1 cannabinoid receptor signalling bias using joint kinetic modelling

British journal of pharmacology, 2020-08, Vol.177 (15), p.3449-3463

2020

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A kinetic model for positive allosteric modulator (PAM)-antagonists for the type 1 cannabinoid (CB 1 ) receptor

British journal of pharmacology, 2023-10, Vol.180 (20), p.2661-2676

2023

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A quantitative pharmacology model for cannabinoid CB1 receptor mediated by Gi/Gs protein competition

British journal of pharmacology, 2024-04, Vol.181 (8), p.1324-1340

2024

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Pharmacological selection of cannabinoid receptor effectors: Signalling, allosteric modulation and bias

Neuropharmacology, 2021-08, Vol.193, p.108611, Article 108611

2021

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Gαs signalling of the CB1 receptor and the influence of receptor number

British journal of pharmacology, 2017-08, Vol.174 (15), p.2545-2562

2017

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Signalling profiles of a structurally diverse panel of synthetic cannabinoid receptor agonists

Biochemical pharmacology, 2020-05, Vol.175, p.113871, Article 113871

2020

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An evaluation of the operational model when applied to quantify functional selectivity

British journal of pharmacology, 2018-05, Vol.175 (10), p.1654-1668

2018

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Exploring determinants of agonist efficacy at the CB1 cannabinoid receptor: Analogues of the synthetic cannabinoid receptor agonist EG‐018

Pharmacology research & perspectives, 2022-02, Vol.10 (1), p.e00901-n/a

2022

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Exploring group size for statistical analysis of real‐time signalling experiments

British journal of pharmacology, 2021-10, Vol.178 (19), p.3997-4004

2021

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Evaluation of the profiles of CB 1 cannabinoid receptor signalling bias using joint kinetic modelling

British journal of pharmacology, 2020-08, Vol.177 (15), p.3449-3463

2020

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Insight into the mechanism of action of ORG27569 at the cannabinoid type one receptor utilising a unified mathematical model

Naunyn-Schmiedeberg's archives of pharmacology, 2024-07, Vol.397 (7), p.5105-5118

2024

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RAMP and MRAP accessory proteins have selective effects on expression and signalling of the CB1, CB2, GPR18 and GPR55 cannabinoid receptors

British journal of pharmacology, 2024-07, Vol.181 (14), p.2212-2231

2024

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Positive allosteric modulation of the cannabinoid CB 1 receptor potentiates endocannabinoid signalling and changes ERK1/2 phosphorylation kinetics

British journal of pharmacology, 2024-10, Vol.181 (19), p.3642-3662

2024

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Biased agonism at the cannabinoid receptors – Evidence from synthetic cannabinoid receptor agonists

Terpenoids From Cannabis Do Not Mediate an Entourage Effect by Acting at Cannabinoid Receptors

Cannabinoid CB1 and CB2 Receptor-Mediated Arrestin Translocation: Species, Subtype, and Agonist-Dependence

GPR18 undergoes a high degree of constitutive trafficking but is unresponsive to N-Arachidonoyl Glycine

Determination of the Cannabinoid CB1 Receptor's Positive Allosteric Modulator Binding Site through Mutagenesis Studies

100 years of modelling ligand–receptor binding and response: A focus on GPCRs

Evaluating signaling bias for synthetic cannabinoid receptor agonists at the cannabinoid CB2 receptor

Characterisation of AMB-FUBINACA metabolism and CB1-mediated activity of its acid metabolite

GPCR kinase subtype requirements for arrestin-2 and -3 translocation to the cannabinoid CB1 receptor and the consequences on G protein signalling

Cannabinoid 1 (CB1) receptor arrestin subtype‐selectivity and phosphorylation dependence

Model‐free and kinetic modelling approaches for characterising non‐equilibrium pharmacological pathway activity: Internalisation of cannabinoid CB1 receptors

Investigating selectivity and bias for G protein subtypes and β-arrestins by synthetic cannabinoid receptor agonists at the cannabinoid CB1 receptor

Evaluation of the profiles of CB1 cannabinoid receptor signalling bias using joint kinetic modelling

A kinetic model for positive allosteric modulator (PAM)-antagonists for the type 1 cannabinoid (CB 1 ) receptor

A quantitative pharmacology model for cannabinoid CB1 receptor mediated by Gi/Gs protein competition

Pharmacological selection of cannabinoid receptor effectors: Signalling, allosteric modulation and bias

Gαs signalling of the CB1 receptor and the influence of receptor number

Signalling profiles of a structurally diverse panel of synthetic cannabinoid receptor agonists

An evaluation of the operational model when applied to quantify functional selectivity

Exploring determinants of agonist efficacy at the CB1 cannabinoid receptor: Analogues of the synthetic cannabinoid receptor agonist EG‐018

Exploring group size for statistical analysis of real‐time signalling experiments

Evaluation of the profiles of CB 1 cannabinoid receptor signalling bias using joint kinetic modelling

Insight into the mechanism of action of ORG27569 at the cannabinoid type one receptor utilising a unified mathematical model

RAMP and MRAP accessory proteins have selective effects on expression and signalling of the CB1, CB2, GPR18 and GPR55 cannabinoid receptors

Positive allosteric modulation of the cannabinoid CB 1 receptor potentiates endocannabinoid signalling and changes ERK1/2 phosphorylation kinetics

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