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TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

Molecular cell, 2012-08, Vol.47 (4), p.535-546

2012

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Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

Molecular cell, 2010-07, Vol.39 (2), p.171-183

2010

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Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

Cell, 2009-02, Vol.136 (3), p.521-534

2009

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ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

Nature (London), 2012-05, Vol.485 (7397), p.195-200

2012

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RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

Nature cell biology, 2011-05, Vol.13 (5), p.623

2011

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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

Molecular cancer therapeutics, 2008-07, Vol.7 (7), p.1851-1863

2008

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Relieving Autophagy and 4EBP1 from Rapamycin Resistance

Molecular and Cellular Biology, 2011-07, Vol.31 (14), p.2867-2876

2011

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Defective Autophagy and mTORC1 Signaling in Myotubularin Null Mice

Molecular and Cellular Biology, 2013-01, Vol.33 (1), p.98-110

2013

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RAD001 enhances the potency of BEZ235 to inhibit mTOR signaling and tumor growth

PloS one, 2012-11, Vol.7 (11), p.e48548

2012

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Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies

Proceedings of the National Academy of Sciences - PNAS, 2010-08, Vol.107 (35), p.15473-15478

2010

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Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

Nature cell biology, 2014-11, Vol.16 (11), p.1069

2014

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R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5

PloS one, 2012-07, Vol.7 (7), p.e40976-e40976

2012

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Rescue screens with secreted proteins reveal compensatory potential of receptor tyrosine kinases in driving cancer growth

Cancer discovery, 2012-10, Vol.2 (10), p.948-959

2012

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Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39

Nature chemical biology, 2014-05, Vol.10 (5), p.343

2014

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Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo

ACS medicinal chemistry letters, 2016-01, Vol.7 (1), p.72-76

2016

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Down-Regulation of Class II Phosphoinositide 3-Kinase α Expression below a Critical Threshold Induces Apoptotic Cell Death

Molecular cancer research, 2008-04, Vol.6 (4), p.614-623

2008

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IL-10 expression profiling in human monocytes

Journal of leukocyte biology, 2002-10, Vol.72 (4), p.800-809

2002

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Regulation of P-Rex1 by Phosphatidylinositol (3,4,5)-Trisphosphate and Gβγ Subunits

The Journal of biological chemistry, 2005-02, Vol.280 (6), p.4166-4173

2005

Volltextzugriff (PDF)

Expression and Characterization of a 5-oxo-6E,8Z,11Z,14Z-Eicosatetraenoic Acid Receptor Highly Expressed on Human Eosinophils and Neutrophils

Molecular pharmacology, 2003-03, Vol.63 (3), p.471-477

2003

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

Nature (London), 2012-03, Vol.483 (7391), p.603-607

2012

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PIKfyve, a Class III PI Kinase, Is the Target of the Small Molecular IL-12/IL-23 Inhibitor Apilimod and a Player in Toll-like Receptor Signaling

Chemistry & biology, 2013-07, Vol.20 (7), p.912-921

2013

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Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

Nature (London), 2012-12, Vol.492 (7428), p.290-290

2012

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Abstract 5014: Profile of ARX001822, a highly potent, selective and orally bioavailable A2a antagonist effective in preventing adenosinergic suppression of T cell activation

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.5014-5014

2019

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TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

Relieving Autophagy and 4EBP1 from Rapamycin Resistance

Defective Autophagy and mTORC1 Signaling in Myotubularin Null Mice

RAD001 enhances the potency of BEZ235 to inhibit mTOR signaling and tumor growth

Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5

Rescue screens with secreted proteins reveal compensatory potential of receptor tyrosine kinases in driving cancer growth

Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39

Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo

Down-Regulation of Class II Phosphoinositide 3-Kinase α Expression below a Critical Threshold Induces Apoptotic Cell Death

IL-10 expression profiling in human monocytes

Regulation of P-Rex1 by Phosphatidylinositol (3,4,5)-Trisphosphate and Gβγ Subunits

Expression and Characterization of a 5-oxo-6E,8Z,11Z,14Z-Eicosatetraenoic Acid Receptor Highly Expressed on Human Eosinophils and Neutrophils

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

PIKfyve, a Class III PI Kinase, Is the Target of the Small Molecular IL-12/IL-23 Inhibitor Apilimod and a Player in Toll-like Receptor Signaling

Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

Abstract 5014: Profile of ARX001822, a highly potent, selective and orally bioavailable A2a antagonist effective in preventing adenosinergic suppression of T cell activation

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