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Prostaglandin J2: a potential target for halting inflammation-induced neurodegeneration

Annals of the New York Academy of Sciences, 2016-01, Vol.1363 (1), p.125-137

2016

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Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications

Apoptosis (London), 2010-11, Vol.15 (11), p.1292-1311

2010

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The Ubiquitin-Proteasome System: Potential Therapeutic Targets for Alzheimer's Disease and Spinal Cord Injury

Frontiers in molecular neuroscience, 2016-01, Vol.9, p.4-4

2016

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Aging and regulated protein degradation: who has the UPPer hand?

Aging cell, 2007-10, Vol.6 (5), p.599-606

2007

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Proteasome-caspase-cathepsin sequence leading to tau pathology induced by prostaglandin J2 in neuronal cells

Journal of neurochemistry, 2009-07, Vol.110 (1), p.328-342

2009

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Relationship Between Tau Pathology and Neuroinflammation in Alzheimer's Disease

The Mount Sinai journal of medicine, 2010-01, Vol.77 (1), p.50-58

2010

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PACAP27 mitigates an age‐dependent hippocampal vulnerability to PGJ2‐induced spatial learning deficits and neuroinflammation in mice

Brain and behavior, 2020-01, Vol.10 (1), p.e01465-n/a

2020

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Neuroinflammation and J2 prostaglandins: linking impairment of the ubiquitin-proteasome pathway and mitochondria to neurodegeneration

Frontiers in molecular neuroscience, 2015-01, Vol.7, p.104

2015

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Aging perturbs 26S proteasome assembly in Drosophila melanogaster

The FASEB journal, 2007-09, Vol.21 (11), p.2672-2682

2007

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Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62

The Journal of biological chemistry, 2011-06, Vol.286 (25), p.22426-22440

2011

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Subchronic infusion of the product of inflammation prostaglandin J2 models sporadic Parkinson's disease in mice

Journal of neuroinflammation, 2009-07, Vol.6 (1), p.18-18, Article 18

2009

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Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: potential novel therapeutic targets

Journal of neuroinflammation, 2018-09, Vol.15 (1), p.272-272, Article 272

2018

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Regulating the Ubiquitin/Proteasome Pathway Via cAMP-signaling: Neuroprotective Potential

Cell biochemistry and biophysics, 2013-09, Vol.67 (1), p.55-66

2013

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Repurposing ibudilast to mitigate Alzheimer’s disease by targeting inflammation

Brain (London, England : 1878), 2023-03, Vol.146 (3), p.898-911

2023

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Prostaglandin J2 promotes O-GlcNAcylation raising APP processing by α- and β-secretases: relevance to Alzheimer's disease

Neurobiology of aging, 2018-02, Vol.62, p.130-145

2018

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Negative Regulation of 26S Proteasome Stability via Calpain-mediated Cleavage of Rpn10 Subunit upon Mitochondrial Dysfunction in Neurons

The Journal of biological chemistry, 2013-04, Vol.288 (17), p.12161-12174

2013

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Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease

Biochimica et biophysica acta. Molecular basis of disease, 2017-06, Vol.1863 (6), p.1157-1170

2017

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Chronic voluntary oral methamphetamine induces deficits in spatial learning and hippocampal protein kinase Mzeta with enhanced astrogliosis and cyclooxygenase-2 levels

Heliyon, 2018-02, Vol.4 (2), p.e00509, Article e00509

2018

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Δ12-Prostaglandin J2 inhibits the ubiquitin hydrolase UCH-L1 and elicits ubiquitin–protein aggregation without proteasome inhibition

Biochemical and biophysical research communications, 2004-07, Vol.319 (4), p.1171-1180

2004

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Cytoskeleton/Endoplasmic Reticulum Collapse Induced by Prostaglandin J2 Parallels Centrosomal Deposition of Ubiquitinated Protein Aggregates

The Journal of biological chemistry, 2006-08, Vol.281 (32), p.23274-23284

2006

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Abeta(1–40)-induced secretion of matrix metalloproteinase-9 results in sAPPα release by association with cell surface APP

Neurobiology of disease, 2007-12, Vol.28 (3), p.304-315

2007

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cAMP stimulates the ubiquitin/proteasome pathway in rat spinal cord neurons

Neuroscience letters, 2012-10, Vol.527 (2), p.126-131

2012

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Mitochondrial and calcium perturbations in rat CNS neurons induce calpain-cleavage of Parkin: Phosphatase inhibition stabilizes pSer65Parkin reducing its calpain-cleavage

Biochimica et biophysica acta. Molecular basis of disease, 2019-06, Vol.1865 (6), p.1436-1450

2019

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Prostaglandin J2 Alters Pro-survival and Pro-death Gene Expression Patterns and 26 S Proteasome Assembly in Human Neuroblastoma Cells

The Journal of biological chemistry, 2006-07, Vol.281 (30), p.21377-21386

2006

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N-Acetylcysteine and Celecoxib Lessen Cadmium Cytotoxicity Which Is Associated with Cyclooxygenase-2 Up-regulation in Mouse Neuronal Cells

The Journal of biological chemistry, 2002-07, Vol.277 (28), p.25283-25289

2002

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Prostaglandin J2: a potential target for halting inflammation-induced neurodegeneration

Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications

The Ubiquitin-Proteasome System: Potential Therapeutic Targets for Alzheimer's Disease and Spinal Cord Injury

Aging and regulated protein degradation: who has the UPPer hand?

Proteasome-caspase-cathepsin sequence leading to tau pathology induced by prostaglandin J2 in neuronal cells

Relationship Between Tau Pathology and Neuroinflammation in Alzheimer's Disease

PACAP27 mitigates an age‐dependent hippocampal vulnerability to PGJ2‐induced spatial learning deficits and neuroinflammation in mice

Neuroinflammation and J2 prostaglandins: linking impairment of the ubiquitin-proteasome pathway and mitochondria to neurodegeneration

Aging perturbs 26S proteasome assembly in Drosophila melanogaster

Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62

Subchronic infusion of the product of inflammation prostaglandin J2 models sporadic Parkinson's disease in mice

Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: potential novel therapeutic targets

Regulating the Ubiquitin/Proteasome Pathway Via cAMP-signaling: Neuroprotective Potential

Repurposing ibudilast to mitigate Alzheimer’s disease by targeting inflammation

Prostaglandin J2 promotes O-GlcNAcylation raising APP processing by α- and β-secretases: relevance to Alzheimer's disease

Negative Regulation of 26S Proteasome Stability via Calpain-mediated Cleavage of Rpn10 Subunit upon Mitochondrial Dysfunction in Neurons

Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease

Chronic voluntary oral methamphetamine induces deficits in spatial learning and hippocampal protein kinase Mzeta with enhanced astrogliosis and cyclooxygenase-2 levels

Δ12-Prostaglandin J2 inhibits the ubiquitin hydrolase UCH-L1 and elicits ubiquitin–protein aggregation without proteasome inhibition

Cytoskeleton/Endoplasmic Reticulum Collapse Induced by Prostaglandin J2 Parallels Centrosomal Deposition of Ubiquitinated Protein Aggregates

Abeta(1–40)-induced secretion of matrix metalloproteinase-9 results in sAPPα release by association with cell surface APP

cAMP stimulates the ubiquitin/proteasome pathway in rat spinal cord neurons

Mitochondrial and calcium perturbations in rat CNS neurons induce calpain-cleavage of Parkin: Phosphatase inhibition stabilizes pSer65Parkin reducing its calpain-cleavage

Prostaglandin J2 Alters Pro-survival and Pro-death Gene Expression Patterns and 26 S Proteasome Assembly in Human Neuroblastoma Cells

N-Acetylcysteine and Celecoxib Lessen Cadmium Cytotoxicity Which Is Associated with Cyclooxygenase-2 Up-regulation in Mouse Neuronal Cells

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