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Deep mutational scanning: a new style of protein science

Nature methods, 2014-08, Vol.11 (8), p.801

2014

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Dimensionality reduction by UMAP to visualize physical and genetic interactions

Nature communications, 2020-03, Vol.11 (1), p.1537-1537, Article 1537

2020

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Dynamics of Gene Expression in Single Root Cells of Arabidopsis thaliana

The Plant cell, 2019-05, Vol.31 (5), p.993-1011

2019

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Interactive learning: Lessons from two hybrids over two decades

Proteomics (Weinheim), 2009-12, Vol.9 (23), p.5209-5213

Fields, Stanley

2009

Volltextzugriff (PDF)

Deep learning of the regulatory grammar of yeast 5' untranslated regions from 500,000 random sequences

Genome research, 2017-12, Vol.27 (12), p.2015

2017

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Adjacent Codons Act in Concert to Modulate Translation Efficiency in Yeast

Cell, 2016-07, Vol.166 (3), p.679-690

2016

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Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation

Nature methods, 2013-07, Vol.10 (7), p.676

2013

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The regulatory landscape of Arabidopsis thaliana roots at single-cell resolution

Nature communications, 2021-06, Vol.12 (1), p.3334-3334, Article 3334

2021

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High‐throughput two‐hybrid analysis

The FEBS journal, 2005-11, Vol.272 (21), p.5391-5399

Fields, Stanley

2005

Volltextzugriff (PDF)

Measuring the activity of protein variants on a large scale using deep mutational scanning

Nature protocols, 2014-09, Vol.9 (9), p.2267-2284

2014

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Engineering an allosteric transcription factor to respond to new ligands

Nature methods, 2016-02, Vol.13 (2), p.177

2016

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A Multiplex Homology-Directed DNA Repair Assay Reveals the Impact of More Than 1,000 BRCA1 Missense Substitution Variants on Protein Function

American journal of human genetics, 2018-10, Vol.103 (4), p.498-508

2018

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Massively Parallel Functional Analysis of BRCA1 RING Domain Variants

Genetics (Austin), 2015-06, Vol.200 (2), p.413-422

2015

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fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function

Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (42), p.16858-16863

2012

Volltextzugriff (PDF)

High-resolution mapping of protein sequence-function relationships

Nature methods, 2010-09, Vol.7 (9), p.741

2010

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Deep mutational scanning of an RRM domain of the Saccharomyces cerevisiae poly(A)-binding protein

RNA (Cambridge), 2013-11, Vol.19 (11), p.1537-1551

2013

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Global mapping of protein-DNA interactions in vivo by digital genomic footprinting

Nature methods, 2009-04, Vol.6 (4), p.283-289

2009

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A network of protein-protein interactions in yeast

Nature biotechnology, 2000-12, Vol.18 (12), p.1257-1261

2000

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Extension of chronological life span in yeast by decreased TOR pathway signaling

Genes & development, 2006-01, Vol.20 (2), p.174-184

2006

Volltextzugriff (PDF)

Enrich: software for analysis of protein function by enrichment and depletion of variants

Bioinformatics, 2011-12, Vol.27 (24), p.3430-3431

2011

Volltextzugriff (PDF)

Expanding the binding specificity for RNA recognition by a PUF domain

Nature communications, 2021-08, Vol.12 (1), p.5107-15, Article 5107

2021

Volltextzugriff (PDF)

Arabidopsis and maize terminator strength is determined by GC content, polyadenylation motifs and cleavage probability

Nature communications, 2024-07, Vol.15 (1), p.5868-21, Article 5868

2024

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A general strategy to construct small molecule biosensors in eukaryotes

eLife, 2015-12, Vol.4

2015

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Effects of sequence motifs in the yeast 3' untranslated region determined from massively parallel assays of random sequences

Genome Biology, 2021-10, Vol.22 (1), p.293-293, Article 293

2021

Volltextzugriff (PDF)

Publisher Correction: Expanding the binding specificity for RNA recognition by a PUF domain

Nature communications, 2022-06, Vol.13 (1), p.3693-3693, Article 3693

2022

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Deep mutational scanning: a new style of protein science

Dimensionality reduction by UMAP to visualize physical and genetic interactions

Dynamics of Gene Expression in Single Root Cells of Arabidopsis thaliana

Interactive learning: Lessons from two hybrids over two decades

Deep learning of the regulatory grammar of yeast 5' untranslated regions from 500,000 random sequences

Adjacent Codons Act in Concert to Modulate Translation Efficiency in Yeast

Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation

The regulatory landscape of Arabidopsis thaliana roots at single-cell resolution

High‐throughput two‐hybrid analysis

Measuring the activity of protein variants on a large scale using deep mutational scanning

Engineering an allosteric transcription factor to respond to new ligands

A Multiplex Homology-Directed DNA Repair Assay Reveals the Impact of More Than 1,000 BRCA1 Missense Substitution Variants on Protein Function

Massively Parallel Functional Analysis of BRCA1 RING Domain Variants

fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function

High-resolution mapping of protein sequence-function relationships

Deep mutational scanning of an RRM domain of the Saccharomyces cerevisiae poly(A)-binding protein

Global mapping of protein-DNA interactions in vivo by digital genomic footprinting

A network of protein-protein interactions in yeast

Extension of chronological life span in yeast by decreased TOR pathway signaling

Enrich: software for analysis of protein function by enrichment and depletion of variants

Expanding the binding specificity for RNA recognition by a PUF domain

Arabidopsis and maize terminator strength is determined by GC content, polyadenylation motifs and cleavage probability

A general strategy to construct small molecule biosensors in eukaryotes

Effects of sequence motifs in the yeast 3' untranslated region determined from massively parallel assays of random sequences

Publisher Correction: Expanding the binding specificity for RNA recognition by a PUF domain

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