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Predicting the Effect of Amino Acid Single-Point Mutations on Protein Stability—Large-Scale Validation of MD-Based Relative Free Energy Calculations

Journal of molecular biology, 2017-04, Vol.429 (7), p.948-963

2017

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Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

Proceedings of the National Academy of Sciences - PNAS, 2013-09, Vol.110 (36), p.E3445-E3454

2013

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Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology

Science signaling, 2017-11, Vol.10 (505)

2017

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A general approach to site-specific antibody drug conjugates

Proceedings of the National Academy of Sciences - PNAS, 2014-02, Vol.111 (5), p.1766-1771

2014

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Functional, Biophysical, and Structural Bases for Antibacterial Activity of Tigecycline

Antimicrobial Agents and Chemotherapy, 2006-06, Vol.50 (6), p.2156-2166

2006

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Discovery of Sulanemadlin (ALRN-6924), the First Cell-Permeating, Stabilized α‑Helical Peptide in Clinical Development

Journal of medicinal chemistry, 2023-07, Vol.66 (14), p.9401-9417

2023

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Identification of a New Member of the Tryptase Family of Mouse and Human Mast Cell Proteases Which Possesses a Novel COOH-terminal Hydrophobic Extension

The Journal of biological chemistry, 1999-10, Vol.274 (43), p.30784-30793

1999

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Modeling mutations in protein structures

Protein science, 2007-09, Vol.16 (9), p.2030-2041

2007

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Peripheral Administration of a Long-Acting Peptide Oxytocin Receptor Agonist Inhibits Fear-Induced Freezing

The Journal of pharmacology and experimental therapeutics, 2016-08, Vol.358 (2), p.164

2016

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Development of an Informatics Platform for Therapeutic Protein and Peptide Analytics

Journal of chemical information and modeling, 2013-10, Vol.53 (10), p.2774-2779

2013

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The Role of Bridging Water and Hydrogen Bonding as Key Determinants of Noncovalent Protein–Carbohydrate Recognition

ChemMedChem, 2018-12, Vol.13 (24), p.2684-2693

2018

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Mouse Mast Cell Protease 9, a Novel Member of the Chromosome 14 Family of Serine Proteases that is Selectively Expressed in Uterine Mast Cells

The Journal of biological chemistry, 1997-11, Vol.272 (46), p.29158-29166

1997

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Fragment-based drug design

Methods in molecular biology (Clifton, N.J.), 2011, Vol.685, p.241

2011

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CONFIRM: connecting fragments found in receptor molecules

Journal of computer-aided molecular design, 2008-10, Vol.22 (10), p.761-772

2008

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Stapled [alpha]-helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

Proceedings of the National Academy of Sciences - PNAS, 2013-09, Vol.110 (36), p.E3445

2013

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Stapled α-helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

Proceedings of the National Academy of Sciences - PNAS, 2013-09, Vol.110 (36), p.14519-14519

2013

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Abstract 5691: Novel site-specific antibody drug conjugates based on novel amino acid incorporation technology have improved pharmaceutical properties over conventional antibody drug conjugates

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.5691-5691

2012

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A structural informatics approach to mine kinase knowledge bases

Drug discovery today, 2010-03, Vol.15 (5), p.203-209

2010

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A structural information approach to mine kinase knowledge bases

Drug discovery today, 2010, Vol.15 (5-6), p.203-209

2010

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Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: A class of potent aggrecanase-1 inhibitors

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (9), p.2487-2491

2009

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Formation of Enzymatically Active, Homotypic, and Heterotypic Tetramers of Mouse Mast Cell Tryptases

The Journal of biological chemistry, 2000-01, Vol.275 (1), p.351-358

2000

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Design and synthesis of 3,3-piperidine hydroxamate analogs as selective TACE inhibitors

Bioorganic & medicinal chemistry letters, 2007-08, Vol.17 (15), p.4333-4337

2007

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Protein Relational Database and Protein Family Knowledge Bases to Facilitate Structure-Based Design Analyses

Chemical biology & drug design, 2010-08, Vol.76 (2), p.142-153

2010

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Formation of enzymatically active, homotypic, and heterotypic tetramers of mouse mast cell tryptases. Dependence on a conserved Trp-rich domain on the surface

The Journal of biological chemistry, 2000-01, Vol.275 (1), p.351-358

2000

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Influence of a NH2‐terminal extension on the activity of KTX2, a K+ channel blocker purified from Androctonus australis scorpion venom

FEBS letters, 1997-11, Vol.417 (1), p.123-129

1997

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Predicting the Effect of Amino Acid Single-Point Mutations on Protein Stability—Large-Scale Validation of MD-Based Relative Free Energy Calculations

Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology

A general approach to site-specific antibody drug conjugates

Functional, Biophysical, and Structural Bases for Antibacterial Activity of Tigecycline

Discovery of Sulanemadlin (ALRN-6924), the First Cell-Permeating, Stabilized α‑Helical Peptide in Clinical Development

Identification of a New Member of the Tryptase Family of Mouse and Human Mast Cell Proteases Which Possesses a Novel COOH-terminal Hydrophobic Extension

Modeling mutations in protein structures

Peripheral Administration of a Long-Acting Peptide Oxytocin Receptor Agonist Inhibits Fear-Induced Freezing

Development of an Informatics Platform for Therapeutic Protein and Peptide Analytics

The Role of Bridging Water and Hydrogen Bonding as Key Determinants of Noncovalent Protein–Carbohydrate Recognition

Mouse Mast Cell Protease 9, a Novel Member of the Chromosome 14 Family of Serine Proteases that is Selectively Expressed in Uterine Mast Cells

Fragment-based drug design

CONFIRM: connecting fragments found in receptor molecules

Stapled [alpha]-helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

Stapled α-helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

Abstract 5691: Novel site-specific antibody drug conjugates based on novel amino acid incorporation technology have improved pharmaceutical properties over conventional antibody drug conjugates

A structural informatics approach to mine kinase knowledge bases

A structural information approach to mine kinase knowledge bases

Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: A class of potent aggrecanase-1 inhibitors

Formation of Enzymatically Active, Homotypic, and Heterotypic Tetramers of Mouse Mast Cell Tryptases

Design and synthesis of 3,3-piperidine hydroxamate analogs as selective TACE inhibitors

Protein Relational Database and Protein Family Knowledge Bases to Facilitate Structure-Based Design Analyses

Formation of enzymatically active, homotypic, and heterotypic tetramers of mouse mast cell tryptases. Dependence on a conserved Trp-rich domain on the surface

Influence of a NH2‐terminal extension on the activity of KTX2, a K+ channel blocker purified from Androctonus australis scorpion venom

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