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From 2D to 3D--a New Dimension for Modelling the Effect of Natural Products on Human Tissue

Current pharmaceutical design, 2015-01, Vol.21 (38), p.5605

2015

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Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line

Toxicological sciences, 2012-06, Vol.127 (2), p.403-411

2012

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The cultural divide: exponential growth in classical 2D and metabolic equilibrium in 3D environments

PloS one, 2014-09, Vol.9 (9), p.e106973-e106973

2014

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A Double-Edged Sword: Thioxanthenes Act on Both the Mind and the Microbiome

Molecules (Basel, Switzerland), 2021-12, Vol.27 (1), p.196

2021

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Metabolic Reprogramming and the Recovery of Physiological Functionality in 3D Cultures in Micro-Bioreactors

Bioengineering (Basel), 2018-03, Vol.5 (1), p.22

2018

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Top-down and Middle-down Protein Analysis Reveals that Intact and Clipped Human Histones Differ in Post-translational Modification Patterns[S]

Molecular & cellular proteomics, 2015-12, Vol.14 (12), p.3142-3153

2015

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Response to and recovery from treatment in human liver-mimetic clinostat spheroids: a model for assessing repeated-dose drug toxicity

Toxicology research (Cambridge), 2020-07, Vol.9 (4), p.379-389

2020

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Clinostat 3D Cell Culture: Protocols for the Preparation and Functional Analysis of Highly Reproducible, Large, Uniform Spheroids and Organoids

Methods in molecular biology (Clifton, N.J.), 2021, Vol.2273, p.17

2021

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A sub-chronic Xysmalobium undulatum hepatotoxicity investigation in HepG2/C3A spheroid cultures compared to an in vivo model

Journal of ethnopharmacology, 2019-07, Vol.239, p.111897, Article 111897

2019

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Recent advances in three-dimensional cell culturing to assess liver function and dysfunction: from a drug biotransformation and toxicity perspective

Toxicology mechanisms and methods, 2018-06, Vol.28 (5), p.1-385

2018

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After trypsinisation, 3D spheroids of C3A hepatocytes need 18 days to re-establish similar levels of key physiological functions to those seen in the liver

Toxicology research (Cambridge), 2013-01, Vol.2 (2), p.123-135

2013

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Heteromer score-using internal standards to assess the quality of proteomic data

Proteomics (Weinheim), 2014-05, Vol.14 (9), p.1042-1047

2014

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Toxicity and anti-prolific properties of Xysmalobium undulatum water extract during short-term exposure to two-dimensional and three-dimensional spheroid cell cultures

Toxicology mechanisms and methods, 2018-11, Vol.28 (9), p.641-652

2018

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Z-2-(β-d-glucopyranosyloxy)-3-phenylpropenoic acid, an α-hydroxy acid from rooibos (Aspalathus linearis) with hypoglycemic activity

Molecular nutrition & food research, 2013-12, Vol.57 (12), p.2216-2222

2013

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Proteome Profiling of Populus euphratica Oliv. Upon Heat Stress

Annals of botany, 2006-08, Vol.98 (2), p.361-377

2006

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Acetaminophen-induced S -nitrosylation and S -sulfenylation signalling in 3D cultured hepatocarcinoma cell spheroids

Toxicology research (Cambridge), 2016-05, Vol.5 (3), p.905-920

2016

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Molar ratios of therapeutic water-soluble phenothiazine·water-insoluble phospholipid adducts reveal a Fibonacci correlation and a putative link for structure-activity relationships

RSC advances, 2015, Vol.5 (27), p.2865-2877

2015

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Proteome analysis reveals phosphorylation of ATP synthase beta -subunit in human skeletal muscle and proteins with potential roles in type 2 diabetes

The Journal of biological chemistry, 2003-03, Vol.278 (12), p.10436-10442

2003

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2D or not 2D

Current Opinion in Chemical Biology, 2001-02, Vol.5 (1), p.26-33

2001

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HepG2/C3A 3D spheroids exhibit stable physiological functionality for at least 24 days after recovering from trypsinisation

Toxicology research (Cambridge), 2013-01, Vol.2 (3), p.163-172

2013

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Stress-induced premature senescence and replicative senescence are different phenotypes, proteomic evidence

Biochemical pharmacology, 2002-09, Vol.64 (5-6), p.1011-1017

2002

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Phospho-proteomics: Evaluation of the use of enzymatic de-phosphorylation and differential mass spectrometric peptide mass mapping for site specific phosphorylation assignment in proteins separated by gel electrophoresis

Proteomics (Weinheim), 2001-02, Vol.1 (2), p.223-238

2001

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Assessing CMT cell line stability by two dimensional polyacrylamide gel electrophoresis and mass spectrometry based proteome analysis

Journal of proteomics, 2008-07, Vol.71 (2), p.160-167

2008

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Microgravity spheroids as a reliable, long-term tool for predictive toxicology

Toxicology letters, 2013-08, Vol.221, p.S153-S153

2013

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Cytokine- or chemically derived nitric oxide alters the expression of proteins detected by two-dimensional gel electrophoresis in neonatal rat islets of Langerhans

Diabetes (New York, N.Y.), 2000-11, Vol.49 (11), p.1819-1829

2000

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From 2D to 3D--a New Dimension for Modelling the Effect of Natural Products on Human Tissue

Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line

The cultural divide: exponential growth in classical 2D and metabolic equilibrium in 3D environments

A Double-Edged Sword: Thioxanthenes Act on Both the Mind and the Microbiome

Metabolic Reprogramming and the Recovery of Physiological Functionality in 3D Cultures in Micro-Bioreactors

Top-down and Middle-down Protein Analysis Reveals that Intact and Clipped Human Histones Differ in Post-translational Modification Patterns[S]

Response to and recovery from treatment in human liver-mimetic clinostat spheroids: a model for assessing repeated-dose drug toxicity

Clinostat 3D Cell Culture: Protocols for the Preparation and Functional Analysis of Highly Reproducible, Large, Uniform Spheroids and Organoids

A sub-chronic Xysmalobium undulatum hepatotoxicity investigation in HepG2/C3A spheroid cultures compared to an in vivo model

Recent advances in three-dimensional cell culturing to assess liver function and dysfunction: from a drug biotransformation and toxicity perspective

After trypsinisation, 3D spheroids of C3A hepatocytes need 18 days to re-establish similar levels of key physiological functions to those seen in the liver

Heteromer score-using internal standards to assess the quality of proteomic data

Toxicity and anti-prolific properties of Xysmalobium undulatum water extract during short-term exposure to two-dimensional and three-dimensional spheroid cell cultures

Z-2-(β-d-glucopyranosyloxy)-3-phenylpropenoic acid, an α-hydroxy acid from rooibos (Aspalathus linearis) with hypoglycemic activity

Proteome Profiling of Populus euphratica Oliv. Upon Heat Stress

Acetaminophen-induced S -nitrosylation and S -sulfenylation signalling in 3D cultured hepatocarcinoma cell spheroids

Molar ratios of therapeutic water-soluble phenothiazine·water-insoluble phospholipid adducts reveal a Fibonacci correlation and a putative link for structure-activity relationships

Proteome analysis reveals phosphorylation of ATP synthase beta -subunit in human skeletal muscle and proteins with potential roles in type 2 diabetes

2D or not 2D

HepG2/C3A 3D spheroids exhibit stable physiological functionality for at least 24 days after recovering from trypsinisation

Stress-induced premature senescence and replicative senescence are different phenotypes, proteomic evidence

Phospho-proteomics: Evaluation of the use of enzymatic de-phosphorylation and differential mass spectrometric peptide mass mapping for site specific phosphorylation assignment in proteins separated by gel electrophoresis

Assessing CMT cell line stability by two dimensional polyacrylamide gel electrophoresis and mass spectrometry based proteome analysis

Microgravity spheroids as a reliable, long-term tool for predictive toxicology

Cytokine- or chemically derived nitric oxide alters the expression of proteins detected by two-dimensional gel electrophoresis in neonatal rat islets of Langerhans

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