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Fusidic Acid: A Bacterial Elongation Factor Inhibitor for the Oral Treatment of Acute and Chronic Staphylococcal Infections

Cold Spring Harbor perspectives in medicine, 2016-01, Vol.6 (1), p.a025437-a025437

Fernandes, Prabhavathi

2016

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Antibacterial discovery and development-the failure of success?

Nature biotechnology, 2006-12, Vol.24 (12), p.1497-1503

Fernandes, Prabhavathi

2006

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Nature nurtures the design of new semi-synthetic macrolide antibiotics

Journal of antibiotics, 2017-05, Vol.70 (5), p.527-533

2017

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Will mortality rates in the next viral pandemic be affected by the COVID-19 experience?

The Journal of infectious diseases, 2024-09

Fernandes, Prabhavathi

2024

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Antibiotics in late clinical development

Biochemical pharmacology, 2017-06, Vol.133, p.152-163

2017

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Molecular Characterization of Off-Target Activities of Telithromycin: a Potential Role for Nicotinic Acetylcholine Receptors

Antimicrobial Agents and Chemotherapy, 2010-12, Vol.54 (12), p.5399-5402

2010

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Antibiotic stewardship programs should include disinfectants and biocides

Journal of antibiotics, 2023-11, Vol.76 (11), p.627-628

Fernandes, Prabhavathi

2023

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SOLITAIRE-IV: A Randomized, Double-Blind, Multicenter Study Comparing the Efficacy and Safety of Intravenous-to-Oral Solithromycin to Intravenous-to-Oral Moxifloxacin for Treatment of Community-Acquired Bacterial Pneumonia

Clinical infectious diseases, 2016-10, Vol.63 (8), p.1007-1016

2016

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In Vitro Activity of the New Fluoroketolide Solithromycin (CEM-101) against a Large Collection of Clinical Neisseria gonorrhoeae Isolates and International Reference Strains, Including Those with High-Level Antimicrobial Resistance: Potential Treatment Option for Gonorrhea?

Antimicrobial Agents and Chemotherapy, 2012-05, Vol.56 (5), p.2739-2742

2012

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Binding and Action of CEM-101, a New Fluoroketolide Antibiotic That Inhibits Protein Synthesis

Antimicrobial Agents and Chemotherapy, 2010-12, Vol.54 (12), p.4961-4970

2010

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Randomized, Double-Blind, Multicenter Phase 2 Study Comparing the Efficacy and Safety of Oral Solithromycin (CEM-101) to Those of Oral Levofloxacin in the Treatment of Patients with Community-Acquired Bacterial Pneumonia

Antimicrobial Agents and Chemotherapy, 2013-06, Vol.57 (6), p.2526-2534

2013

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Efficacy and safety of oral solithromycin versus oral moxifloxacin for treatment of community-acquired bacterial pneumonia: a global, double-blind, multicentre, randomised, active-controlled, non-inferiority trial (SOLITAIRE-ORAL)

The Lancet infectious diseases, 2016-04, Vol.16 (4), p.421-430

2016

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Antimicrobial Activity of Solithromycin against Clinical Isolates of Legionella pneumophila Serogroup 1

Antimicrobial Agents and Chemotherapy, 2014-02, Vol.58 (2), p.909-915

2014

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The global challenge of new classes of antibacterial agents: an industry perspective

Current opinion in pharmacology, 2015-10, Vol.24, p.7-11

Fernandes, Prabhavathi

2015

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Surveillance of the activity of solithromycin (CEM-101) against bacteria from respiratory tract infections

International journal of antimicrobial agents, 2017-07, Vol.50 (1), p.17-22

2017

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Comparison of Plasma, Epithelial Lining Fluid, and Alveolar Macrophage Concentrations of Solithromycin (CEM-101) in Healthy Adult Subjects

Antimicrobial Agents and Chemotherapy, 2012-10, Vol.56 (10), p.5076-5081

2012

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Determination of In Vitro Activities of Solithromycin at Different pHs and Its Intracellular Activity against Clinical Isolates of Neisseria gonorrhoeae from a Laboratory Collection

Antimicrobial Agents and Chemotherapy, 2013-09, Vol.57 (9), p.4322-4328

2013

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In Vitro Activity of Solithromycin against Erythromycin-Resistant Streptococcus agalactiae

Antimicrobial Agents and Chemotherapy, 2014-03, Vol.58 (3), p.1693-1698

2014

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Pharmacokinetics of Solithromycin (CEM-101) after Single or Multiple Oral Doses and Effects of Food on Single-Dose Bioavailability in Healthy Adult Subjects

Antimicrobial Agents and Chemotherapy, 2011-05, Vol.55 (5), p.1997-2003

2011

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Maternal Administration of Solithromycin, a New, Potent, Broad-Spectrum Fluoroketolide Antibiotic, Achieves Fetal and Intra-Amniotic Antimicrobial Protection in a Pregnant Sheep Model

Antimicrobial Agents and Chemotherapy, 2014-01, Vol.58 (1), p.447-454

2014

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Population Pharmacokinetics of Fusidic Acid: Rationale for Front-Loaded Dosing Regimens Due to Autoinhibition of Clearance

Antimicrobial Agents and Chemotherapy, 2013-01, Vol.57 (1), p.498-507

2013

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A Randomized, Double-Blind Phase 2 Study Comparing the Efficacy and Safety of an Oral Fusidic Acid Loading-Dose Regimen to Oral Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infections

Clinical infectious diseases, 2011-06, Vol.52 (suppl_7), p.S520-S526

2011

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In Vitro and In Vivo Activity of Solithromycin (CEM-101) against Plasmodium Species

Antimicrobial Agents and Chemotherapy, 2012-02, Vol.56 (2), p.703-707

2012

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A single 20 mg dose of the full D1 dopamine agonist dihydrexidine (DAR-0100) increases prefrontal perfusion in schizophrenia

Schizophrenia research, 2007-08, Vol.94 (1), p.332-341

2007

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Synthesis and antibacterial activity of novel 4-aryl-[1,2,3]-triazole containing macrolides

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.510-513

2011

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Fusidic Acid: A Bacterial Elongation Factor Inhibitor for the Oral Treatment of Acute and Chronic Staphylococcal Infections

Antibacterial discovery and development-the failure of success?

Nature nurtures the design of new semi-synthetic macrolide antibiotics

Will mortality rates in the next viral pandemic be affected by the COVID-19 experience?

Antibiotics in late clinical development

Molecular Characterization of Off-Target Activities of Telithromycin: a Potential Role for Nicotinic Acetylcholine Receptors

Antibiotic stewardship programs should include disinfectants and biocides

SOLITAIRE-IV: A Randomized, Double-Blind, Multicenter Study Comparing the Efficacy and Safety of Intravenous-to-Oral Solithromycin to Intravenous-to-Oral Moxifloxacin for Treatment of Community-Acquired Bacterial Pneumonia

In Vitro Activity of the New Fluoroketolide Solithromycin (CEM-101) against a Large Collection of Clinical Neisseria gonorrhoeae Isolates and International Reference Strains, Including Those with High-Level Antimicrobial Resistance: Potential Treatment Option for Gonorrhea?

Binding and Action of CEM-101, a New Fluoroketolide Antibiotic That Inhibits Protein Synthesis

Randomized, Double-Blind, Multicenter Phase 2 Study Comparing the Efficacy and Safety of Oral Solithromycin (CEM-101) to Those of Oral Levofloxacin in the Treatment of Patients with Community-Acquired Bacterial Pneumonia

Efficacy and safety of oral solithromycin versus oral moxifloxacin for treatment of community-acquired bacterial pneumonia: a global, double-blind, multicentre, randomised, active-controlled, non-inferiority trial (SOLITAIRE-ORAL)

Antimicrobial Activity of Solithromycin against Clinical Isolates of Legionella pneumophila Serogroup 1

The global challenge of new classes of antibacterial agents: an industry perspective

Surveillance of the activity of solithromycin (CEM-101) against bacteria from respiratory tract infections

Comparison of Plasma, Epithelial Lining Fluid, and Alveolar Macrophage Concentrations of Solithromycin (CEM-101) in Healthy Adult Subjects

Determination of In Vitro Activities of Solithromycin at Different pHs and Its Intracellular Activity against Clinical Isolates of Neisseria gonorrhoeae from a Laboratory Collection

In Vitro Activity of Solithromycin against Erythromycin-Resistant Streptococcus agalactiae

Pharmacokinetics of Solithromycin (CEM-101) after Single or Multiple Oral Doses and Effects of Food on Single-Dose Bioavailability in Healthy Adult Subjects

Maternal Administration of Solithromycin, a New, Potent, Broad-Spectrum Fluoroketolide Antibiotic, Achieves Fetal and Intra-Amniotic Antimicrobial Protection in a Pregnant Sheep Model

Population Pharmacokinetics of Fusidic Acid: Rationale for Front-Loaded Dosing Regimens Due to Autoinhibition of Clearance

A Randomized, Double-Blind Phase 2 Study Comparing the Efficacy and Safety of an Oral Fusidic Acid Loading-Dose Regimen to Oral Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infections

In Vitro and In Vivo Activity of Solithromycin (CEM-101) against Plasmodium Species

A single 20 mg dose of the full D1 dopamine agonist dihydrexidine (DAR-0100) increases prefrontal perfusion in schizophrenia

Synthesis and antibacterial activity of novel 4-aryl-[1,2,3]-triazole containing macrolides

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