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Modulation of immune responses using adjuvants to facilitate therapeutic vaccination

Immunological reviews, 2020-07, Vol.296 (1), p.169-190

2020

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Development of Improved Vaccine Adjuvants Based on the Saponin Natural Product QS-21 through Chemical Synthesis

Accounts of chemical research, 2016-09, Vol.49 (9), p.1741-1756

2016

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Recent Developments in Synthetic Carbohydrate-Based Diagnostics, Vaccines, and Therapeutics

Chemistry : a European journal, 2015-07, Vol.21 (30), p.10616-10628

2015

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Chemical biology tools to interrogate the roles of O -GlcNAc in immunity

Frontiers in immunology, 2023-01, Vol.13, p.1089824-1089824

2023

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Replacing the Rhamnose‐Xylose Moiety of QS‐21 with Simpler Terminal Disaccharide Units Attenuates Adjuvant Activity in Truncated Saponin Variants

Chemistry : a European journal, 2021-03, Vol.27 (14), p.4731-4737

2021

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Design, synthesis, and initial immunological evaluation of glycoconjugates based on saponin adjuvants and the Tn antigen

Chemical communications (Cambridge, England), 2021-10, Vol.57 (86), p.11382-11385

2021

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Advances in chemical probing of protein O -GlcNAc glycosylation: structural role and molecular mechanisms

Chemical Society reviews, 2021-09, Vol.50 (18), p.10451-10485

2021

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Novel Oxime-Derivatized Synthetic Triterpene Glycosides as Potent Saponin Vaccine Adjuvants

Frontiers in immunology, 2022-05, Vol.13, p.865507-865507

2022

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Synthesis and Preclinical Evaluation of QS-21 Variants Leading to Simplified Vaccine Adjuvants and Mechanistic Probes

Journal of the American Chemical Society, 2012-08, Vol.134 (32), p.13448-13457

2012

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Chemical Synthesis of Highly Congested gp120 V1V2 N‑Glycopeptide Antigens for Potential HIV-1-Directed Vaccines

Journal of the American Chemical Society, 2013-09, Vol.135 (35), p.13113-13120

2013

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Antibodies Against Specific MUC16 Glycosylation Sites Inhibit Ovarian Cancer Growth

ACS chemical biology, 2017-08, Vol.12 (8), p.2085-2096

2017

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Chemical Synthesis of the β‑Subunit of Human Luteinizing (hLH) and Chorionic Gonadotropin (hCG) Glycoprotein Hormones

Journal of the American Chemical Society, 2014-06, Vol.136 (23), p.8450-8458

2014

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Recognition of synthetic glycopeptides by HIV-1 broadly neutralizing antibodies and their unmutated ancestors

Proceedings of the National Academy of Sciences - PNAS, 2013-11, Vol.110 (45), p.18214-18219

2013

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Design, synthesis and evaluation of optimized saponin variants derived from the vaccine adjuvant QS-21

Pure and applied chemistry, 2017-09, Vol.89 (9), p.1359-1378

Fernández-Tejada, Alberto

2017

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β-Glucan as an immune activator and a carrier in the construction of a synthetic MUC1 vaccine

Chemical communications (Cambridge, England), 2019, Vol.55 (2), p.253-256

2019

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Rational Vaccine Design in Times of Emerging Diseases: The Critical Choices of Immunological Correlates of Protection, Vaccine Antigen and Immunomodulation

Pharmaceutics, 2021-04, Vol.13 (4), p.501

2021

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Cover Picture: Molecular Recognition of β-O-GlcNAc Glycopeptides by a Lectin-Like Receptor: Binding Modulation by the Underlying Ser or Thr Amino Acids (ChemBioChem 1/2011)

Chembiochem : a European journal of chemical biology, 2011-01, Vol.12 (1), p.1-1

2011

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Exploiting structure-activity relationships of QS-21 in the design and synthesis of streamlined saponin vaccine adjuvants

Chemical communications (Cambridge, England), 2020-01, Vol.56 (5), p.719-722

2020

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Chemical synthesis and immunological evaluation of new generation multivalent anticancer vaccines based on a Tn antigen analogue

Chemical science (Cambridge), 2020-05, Vol.11 (17), p.4488-4498

2020

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Development of synthetic, self-adjuvanting, and self-assembling anticancer vaccines based on a minimal saponin adjuvant and the tumor-associated MUC1 antigen

Chemical science (Cambridge), 2023-03, Vol.14 (13), p.351-3513

2023

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Non-natural Amino Acids as Modulating Agents of the Conformational Space of Model Glycopeptides

Chemistry : a European journal, 2008-08, Vol.14 (23), p.7042-7058

2008

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Advances in chemical probing of protein -GlcNAc glycosylation: structural role and molecular mechanisms

Chemical Society reviews, 2021-09, Vol.5 (18), p.1451-1485

2021

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Insights into the Geometrical Features Underlying β‐O‐GlcNAc Glycosylation: Water Pockets Drastically Modulate the Interactions between the Carbohydrate and the Peptide Backbone

Chemistry : a European journal, 2009-07, Vol.15 (30), p.7297-7301

2009

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Dynamics and Hydration Properties of Small Antifreeze-Like Glycopeptides Containing Non-Natural Amino Acids

European Journal of Organic Chemistry, 2010-06, Vol.2010 (18), p.3525-3532

2010

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Modulation of immune responses using adjuvants to facilitate therapeutic vaccination

Development of Improved Vaccine Adjuvants Based on the Saponin Natural Product QS-21 through Chemical Synthesis

Recent Developments in Synthetic Carbohydrate-Based Diagnostics, Vaccines, and Therapeutics

Chemical biology tools to interrogate the roles of O -GlcNAc in immunity

Replacing the Rhamnose‐Xylose Moiety of QS‐21 with Simpler Terminal Disaccharide Units Attenuates Adjuvant Activity in Truncated Saponin Variants

Design, synthesis, and initial immunological evaluation of glycoconjugates based on saponin adjuvants and the Tn antigen

Advances in chemical probing of protein O -GlcNAc glycosylation: structural role and molecular mechanisms

Novel Oxime-Derivatized Synthetic Triterpene Glycosides as Potent Saponin Vaccine Adjuvants

Synthesis and Preclinical Evaluation of QS-21 Variants Leading to Simplified Vaccine Adjuvants and Mechanistic Probes

Chemical Synthesis of Highly Congested gp120 V1V2 N‑Glycopeptide Antigens for Potential HIV-1-Directed Vaccines

Antibodies Against Specific MUC16 Glycosylation Sites Inhibit Ovarian Cancer Growth

Chemical Synthesis of the β‑Subunit of Human Luteinizing (hLH) and Chorionic Gonadotropin (hCG) Glycoprotein Hormones

Recognition of synthetic glycopeptides by HIV-1 broadly neutralizing antibodies and their unmutated ancestors

Design, synthesis and evaluation of optimized saponin variants derived from the vaccine adjuvant QS-21

β-Glucan as an immune activator and a carrier in the construction of a synthetic MUC1 vaccine

Rational Vaccine Design in Times of Emerging Diseases: The Critical Choices of Immunological Correlates of Protection, Vaccine Antigen and Immunomodulation

Cover Picture: Molecular Recognition of β-O-GlcNAc Glycopeptides by a Lectin-Like Receptor: Binding Modulation by the Underlying Ser or Thr Amino Acids (ChemBioChem 1/2011)

Exploiting structure-activity relationships of QS-21 in the design and synthesis of streamlined saponin vaccine adjuvants

Chemical synthesis and immunological evaluation of new generation multivalent anticancer vaccines based on a Tn antigen analogue

Development of synthetic, self-adjuvanting, and self-assembling anticancer vaccines based on a minimal saponin adjuvant and the tumor-associated MUC1 antigen

Non-natural Amino Acids as Modulating Agents of the Conformational Space of Model Glycopeptides

Advances in chemical probing of protein -GlcNAc glycosylation: structural role and molecular mechanisms

Insights into the Geometrical Features Underlying β‐O‐GlcNAc Glycosylation: Water Pockets Drastically Modulate the Interactions between the Carbohydrate and the Peptide Backbone

Dynamics and Hydration Properties of Small Antifreeze-Like Glycopeptides Containing Non-Natural Amino Acids

Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide

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