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Mre11 Nuclease Activity Has Essential Roles in DNA Repair and Genomic Stability Distinct from ATM Activation

Cell, 2008-10, Vol.135 (1), p.85-96

2008

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Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors

Nature structural & molecular biology, 2015-09, Vol.22 (9), p.736-743

2015

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Multiple functions of MRN in end-joining pathways during isotype class switching

Nature structural & molecular biology, 2009-08, Vol.16 (8), p.808-813

2009

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Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation

Cancer research (Chicago, Ill.), 2007-10, Vol.67 (20), p.9721-9730

2007

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Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution

Nature communications, 2020-07, Vol.11 (1), p.3669-19, Article 3669

2020

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Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms

Human molecular genetics, 2013-12, Vol.22 (25), p.5146-5159

2013

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The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation

Cell research, 2012-02, Vol.22 (2), p.305-320

2012

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The role of DNA breaks in genomic instability and tumorigenesis

Immunological reviews, 2003-08, Vol.194 (1), p.77-95

2003

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DNA double strand break repair and chromosomal translocation: lessons from animal models

Oncogene, 2001-09, Vol.20 (40), p.5572-5579

2001

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The Essential DNA Damage Response Complex MRN Is Dispensable for the Survival and Function of Purkinje Neurons

Frontiers in aging neuroscience, 2022-01, Vol.13, p.786199-786199

2022

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Increased Ionizing Radiation Sensitivity and Genomic Instability in the Absence of Histone H2AX

Proceedings of the National Academy of Sciences - PNAS, 2002-06, Vol.99 (12), p.8173-8178

2002

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Unrepaired DNA Breaks in p53-Deficient Cells Lead to Oncogenic Gene Amplification Subsequent to Translocations

Cell, 2002-06, Vol.109 (7), p.811-821

2002

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Hematopoietic stem cells are acutely sensitive to Acd shelterin gene inactivation

The Journal of clinical investigation, 2014-01, Vol.124 (1), p.353-366

2014

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Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

Nature (London), 2000-04, Vol.404 (6780), p.897-900

2000

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DNA Ligase IV Deficiency in Mice Leads to Defective Neurogenesis and Embryonic Lethality via the p53 Pathway

Molecular cell, 2000-06, Vol.5 (6), p.993-1002

2000

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Multiple roles for MRE11 at uncapped telomeres

Nature (London), 2009-08, Vol.460 (7257), p.914-918

2009

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The Nonhomologous End-Joining Pathway of DNA Repair Is Required for Genomic Stability and the Suppression of Translocations

Proceedings of the National Academy of Sciences - PNAS, 2000-06, Vol.97 (12), p.6630-6633

2000

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Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2

Nature structural & molecular biology, 2012-02, Vol.19 (2), p.246-252

2012

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Defective DNA repair and increased genomic instability in Artemis-deficient murine cells

The Journal of experimental medicine, 2003-03, Vol.197 (5), p.553-565

2003

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Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability

Genes & development, 2004-06, Vol.18 (11), p.1283-1292

2004

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Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation

Blood, 2009-03, Vol.113 (13), p.2965-2975

2009

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Reduced levels of MRE11 cause disease phenotypes distinct from ataxia telangiectasia-like disorder

Human molecular genetics, 2024-09, Vol.33 (18), p.1605-1617

2024

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The Polycomb Group Protein EZH2 Impairs DNA Repair in Breast Epithelial Cells

Neoplasia (New York, N.Y.), 2005-11, Vol.7 (11), p.1011-1019

2005

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Proapoptotic BID is required for myeloid homeostasis and tumor suppression

Genes & development, 2003-01, Vol.17 (2), p.229-239

2003

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Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

Nature, 2006-05, Vol.441 (7092), p.475-482

2006

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Mre11 Nuclease Activity Has Essential Roles in DNA Repair and Genomic Stability Distinct from ATM Activation

Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors

Multiple functions of MRN in end-joining pathways during isotype class switching

Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation

Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution

Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms

The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation

The role of DNA breaks in genomic instability and tumorigenesis

DNA double strand break repair and chromosomal translocation: lessons from animal models

The Essential DNA Damage Response Complex MRN Is Dispensable for the Survival and Function of Purkinje Neurons

Increased Ionizing Radiation Sensitivity and Genomic Instability in the Absence of Histone H2AX

Unrepaired DNA Breaks in p53-Deficient Cells Lead to Oncogenic Gene Amplification Subsequent to Translocations

Hematopoietic stem cells are acutely sensitive to Acd shelterin gene inactivation

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

DNA Ligase IV Deficiency in Mice Leads to Defective Neurogenesis and Embryonic Lethality via the p53 Pathway

Multiple roles for MRE11 at uncapped telomeres

The Nonhomologous End-Joining Pathway of DNA Repair Is Required for Genomic Stability and the Suppression of Translocations

Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2

Defective DNA repair and increased genomic instability in Artemis-deficient murine cells

Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability

Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation

Reduced levels of MRE11 cause disease phenotypes distinct from ataxia telangiectasia-like disorder

The Polycomb Group Protein EZH2 Impairs DNA Repair in Breast Epithelial Cells

Proapoptotic BID is required for myeloid homeostasis and tumor suppression

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

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