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Current State of In vitro Cell-Based Renal Models

Current drug metabolism, 2018-01, Vol.19 (4), p.310-326

2018

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Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data

Drug metabolism and disposition, 2012-05, Vol.40 (5), p.1007-1017

2012

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A comprehensive non‐clinical evaluation of the CNS penetration potential of antimuscarinic agents for the treatment of overactive bladder

British journal of clinical pharmacology, 2011-08, Vol.72 (2), p.235-246

2011

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Targeting intestinal transporters for optimizing oral drug absorption

Current drug metabolism, 2010-11, Vol.11 (9), p.730-742

2010

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Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity

Molecular pharmacology, 2018-07, Vol.94 (1), p.689-699

2018

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Amplifying the Impact of Kidney Microphysiological Systems: Predicting Renal Clearance Using Mechanistic Modelling Based on Reconstructed Drug Secretion

ALTEX, alternatives to animal experimentation, 2023-06, Vol.40 (3), p.408

2023

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pH-Dependent Solubility and Permeability Criteria for Provisional Biopharmaceutics Classification (BCS and BDDCS) in Early Drug Discovery

Molecular pharmaceutics, 2012-05, Vol.9 (5), p.1199-1212

2012

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Absolute immunoquantification of the expression of ABC transporters P-glycoprotein, breast cancer resistance protein and multidrug resistance-associated protein 2 in human liver and duodenum

Biochemical pharmacology, 2012-01, Vol.83 (2), p.279-285

2012

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Survey of pharmaceutical industry's best practices around in vitro transporter assessment and Implications for Drug Development: Considerations from the IQ Transporter Working Group

Drug metabolism and disposition, 2024-05, p.DMD-AR-2023-001587

2024

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In vitro evaluation of hepatic transporter-mediated clinical drug-drug interactions: hepatocyte model optimization and retrospective investigation

Drug metabolism and disposition, 2012-06, Vol.40 (6), p.1085-1092

2012

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Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design

European journal of medicinal chemistry, 2012-11, Vol.57, p.441-448

2012

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Development of a hollow fibre-based renal module for active transport studies

Journal of artificial organs, 2021-12, Vol.24 (4), p.473-484

2021

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Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity

Molecular pharmacology, 2018-07, Vol.94 (1), p.689-699

2018

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The evolution of the OATP hepatic uptake transport protein family in DMPK sciences: from obscure liver transporters to key determinants of hepatobiliary clearance

Xenobiotica, 2012-01, Vol.42 (1), p.28-45

2012

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Differential modulation of cytochrome P450 activity and the effect of 1-aminobenzotriazole on hepatic transport in sandwich-cultured human hepatocytes

Drug metabolism and disposition, 2012-02, Vol.40 (2), p.407-411

2012

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Refining the In Vitro and In Vivo Critical Parameters for P-Glycoprotein, [I]/IC50 and [I2]/IC50, That Allow for the Exclusion of Drug Candidates from Clinical Digoxin Interaction Studies

Molecular pharmaceutics, 2010-04, Vol.7 (2), p.398-411

2010

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N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a “chemical knock-out equivalent” to assess the impact of efflux transporters on oral drug absorption in the rat

Journal of pharmaceutical sciences, 2009-12, Vol.98 (12), p.4914-4927

2009

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Solitary Inhibition of the Breast Cancer Resistance Protein Efflux Transporter Results in a Clinically Significant Drug-Drug Interaction with Rosuvastatin by Causing up to a 2-Fold Increase in Statin Exposure

Drug metabolism and disposition, 2016-03, Vol.44 (3), p.398-408

2016

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A Novel Method for Preventing Non-specific Binding in Equilibrium Dialysis Assays Using Solutol® as an Additive

Journal of pharmaceutical sciences, 2021-03, Vol.110 (3), p.1412-1417

2021

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Amplifying the impact of kidney microphysiological systems: predicting renal drug clearance using mechanistic modelling based on reconstructed drug secretion

ALTEX, alternatives to animal experimentation, 2023-01

Caetano-Pinto, Pedro

2023

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Biosensor Analysis of the Interaction between Drug Compounds and Liposomes of Different Properties; a Two-Dimensional Characterization Tool for Estimation of Membrane Absorption

Journal of pharmaceutical sciences, 2005-01, Vol.94 (1), p.25-37

2005

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Development of a new permeability assay using low‐efflux MDCKII cells

Journal of pharmaceutical sciences, 2011-11, Vol.100 (11), p.4974-4985

2011

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P245 - Investigation of renal drug secretion in a kidney-on-a-chip model

Drug metabolism and pharmacokinetics, 2020, Vol.35 (1), p.S97-S97

2020

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Epidermal growth factor receptor mediates the basolateral uptake of phosphorothioate-modified antisense oligonucleotides in the kidney

Organs-on-a-chip, 2022-12, Vol.4, p.100022, Article 100022

2022

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Current State of In vitro Cell-Based Renal Models

Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data

A comprehensive non‐clinical evaluation of the CNS penetration potential of antimuscarinic agents for the treatment of overactive bladder

Targeting intestinal transporters for optimizing oral drug absorption

Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity

Amplifying the Impact of Kidney Microphysiological Systems: Predicting Renal Clearance Using Mechanistic Modelling Based on Reconstructed Drug Secretion

Survey of Pharmaceutical Industry's Best Practices around In Vitro Transporter Assessment and Implications for Drug Development: Considerations from the International Consortium for Innovation and Quality for Pharmaceutical Development Transporter Working Group

pH-Dependent Solubility and Permeability Criteria for Provisional Biopharmaceutics Classification (BCS and BDDCS) in Early Drug Discovery

Absolute immunoquantification of the expression of ABC transporters P-glycoprotein, breast cancer resistance protein and multidrug resistance-associated protein 2 in human liver and duodenum

Survey of pharmaceutical industry's best practices around in vitro transporter assessment and Implications for Drug Development: Considerations from the IQ Transporter Working Group

In vitro evaluation of hepatic transporter-mediated clinical drug-drug interactions: hepatocyte model optimization and retrospective investigation

Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design

Development of a hollow fibre-based renal module for active transport studies

Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity

The evolution of the OATP hepatic uptake transport protein family in DMPK sciences: from obscure liver transporters to key determinants of hepatobiliary clearance

Differential modulation of cytochrome P450 activity and the effect of 1-aminobenzotriazole on hepatic transport in sandwich-cultured human hepatocytes

Refining the In Vitro and In Vivo Critical Parameters for P-Glycoprotein, [I]/IC50 and [I2]/IC50, That Allow for the Exclusion of Drug Candidates from Clinical Digoxin Interaction Studies

N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a “chemical knock-out equivalent” to assess the impact of efflux transporters on oral drug absorption in the rat

Solitary Inhibition of the Breast Cancer Resistance Protein Efflux Transporter Results in a Clinically Significant Drug-Drug Interaction with Rosuvastatin by Causing up to a 2-Fold Increase in Statin Exposure

A Novel Method for Preventing Non-specific Binding in Equilibrium Dialysis Assays Using Solutol® as an Additive

Amplifying the impact of kidney microphysiological systems: predicting renal drug clearance using mechanistic modelling based on reconstructed drug secretion

Biosensor Analysis of the Interaction between Drug Compounds and Liposomes of Different Properties; a Two-Dimensional Characterization Tool for Estimation of Membrane Absorption

Development of a new permeability assay using low‐efflux MDCKII cells

P245 - Investigation of renal drug secretion in a kidney-on-a-chip model

Epidermal growth factor receptor mediates the basolateral uptake of phosphorothioate-modified antisense oligonucleotides in the kidney

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