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Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds

Molecular cell, 2018-04, Vol.70 (2), p.265-273.e8

2018

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The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action

Genes & development, 2018-02, Vol.32 (3-4), p.309-320

2018

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H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma

Cancer research (Chicago, Ill.), 2017-12, Vol.77 (24), p.6999-7013

2017

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Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators

Nature communications, 2019-01, Vol.10 (1), p.137-137, Article 137

2019

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Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex

Nature communications, 2017-05, Vol.8 (1), p.15522-15522, Article 15522

2017

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Protein Targeting to the Bacterial Cytoplasmic Membrane

Microbiology and Molecular Biology Reviews, 1999-03, Vol.63 (1), p.161-173

1999

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Gag3p, an Outer Membrane Protein Required for Fission of Mitochondrial Tubules

The Journal of cell biology, 2000-10, Vol.151 (2), p.333-340

2000

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Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Nature (London), 2016-07, Vol.535 (7610), p.148-152

2016

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Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer

Journal of medicinal chemistry, 2020-11, Vol.63 (22), p.13578-13594

2020

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Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

Nature cell biology, 2014-11, Vol.16 (11), p.1069

2014

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The R882H DNMT3A hot spot mutation stabilizes the formation of large DNMT3A oligomers with low DNA methyltransferase activity

The Journal of biological chemistry, 2019-11, Vol.294 (45), p.16966-16977

2019

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Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPARγ by inverse agonists

The Journal of biological chemistry, 2022-11, Vol.298 (11), p.102539, Article 102539

2022

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Abstract 281: Sensitivity to splicing modulation of BCL2 family genes reveals cancer therapeutic strategies for splicing modulators

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.281-281

2019

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SecA is an intrinsic subunit of the Escherichia coli preprotein translocase and exposes its carboxyl terminus to the periplasm

Molecular microbiology, 1996-11, Vol.22 (4), p.619-629

1996

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Abstract 126: A chemogenomic approach reveals the action of splicing modulators at the branch point adenosine binding pocket defined by the PHF5A/SF3b complex

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.126-126

2017

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Abstract 3126: H3B6527, a selective and potent FGFR4 inhibitor for FGF19-driven hepatocellular carcinoma

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.3126-3126

2017

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Abstract 1185: H3B-8800, a novel orally available SF3b modulator, shows preclinical efficacy across spliceosome mutant cancers

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.1185-1185

2017

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Abstract DDT01-04: Discovery and development of H3B-6545: A novel, oral, selective estrogen receptor covalent antagonist (SERCA) for the treatment of breast cancer

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.DDT01-04-DDT01-04

2017

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Insoluble hydrophobin complexes in the walls of Schizophyllum commune and other filamentous fungi

Archives of microbiology, 1993-04, Vol.159 (4), p.330-335

1993

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The molecular chaperone SecB is released from the carboxy-terminus of SecA during initiation of precursor protein translocation

The EMBO journal, 1997-10, Vol.16 (20), p.6105-6113

1997

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Abstract 1191: Translational Proof-of-Concept (TransPoC), a not-for-profit research organization enabling access to large-scale translational oncology platforms: The Patient-Derived Xenograft network

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.1191-1191

2014

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Abstract 2941: Targeting MCL1-dependent cancers through RNA splicing modulation

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.2941-2941

2015

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H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers

Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds

The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action

H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma

Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators

Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex

Protein Targeting to the Bacterial Cytoplasmic Membrane

Gag3p, an Outer Membrane Protein Required for Fission of Mitochondrial Tubules

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer

The R882H DNMT3A hot spot mutation stabilizes the formation of large DNMT3A oligomers with low DNA methyltransferase activity

Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPARγ by inverse agonists

Abstract 281: Sensitivity to splicing modulation of BCL2 family genes reveals cancer therapeutic strategies for splicing modulators

SecA is an intrinsic subunit of the Escherichia coli preprotein translocase and exposes its carboxyl terminus to the periplasm

Abstract 126: A chemogenomic approach reveals the action of splicing modulators at the branch point adenosine binding pocket defined by the PHF5A/SF3b complex

Abstract 3126: H3B6527, a selective and potent FGFR4 inhibitor for FGF19-driven hepatocellular carcinoma

H3B-8800, an Orally Bioavailable Modulator of the SF3b Complex, Shows Efficacy in Spliceosome-Mutant Myeloid Malignancies

Abstract 1185: H3B-8800, a novel orally available SF3b modulator, shows preclinical efficacy across spliceosome mutant cancers

Abstract DDT01-04: Discovery and development of H3B-6545: A novel, oral, selective estrogen receptor covalent antagonist (SERCA) for the treatment of breast cancer

Insoluble hydrophobin complexes in the walls of Schizophyllum commune and other filamentous fungi

The molecular chaperone SecB is released from the carboxy-terminus of SecA during initiation of precursor protein translocation

Abstract 1191: Translational Proof-of-Concept (TransPoC), a not-for-profit research organization enabling access to large-scale translational oncology platforms: The Patient-Derived Xenograft network

Abstract 2941: Targeting MCL1-dependent cancers through RNA splicing modulation

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