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The emergence of adaptive laboratory evolution as an efficient tool for biological discovery and industrial biotechnology

Metabolic engineering, 2019-12, Vol.56 (C), p.1-16

2019

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Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells

Molecular cell, 2014-07, Vol.55 (2), p.253-263

2014

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Basic and applied uses of genome‐scale metabolic network reconstructions of Escherichia coli

Molecular systems biology, 2013, Vol.9 (1), p.661-n/a

2013

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ALEdb 1.0: a database of mutations from adaptive laboratory evolution experimentation

Nucleic acids research, 2019-01, Vol.47 (D1), p.D1164

2019

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A Model for Designing Adaptive Laboratory Evolution Experiments

Applied and environmental microbiology, 2017-04, Vol.83 (8), p.E03115

2017

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The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coli

Nature biotechnology, 2008-06, Vol.26 (6), p.659-667

2008

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Use of adaptive laboratory evolution to discover key mutations enabling rapid growth of Escherichia coli K-12 MG1655 on glucose minimal medium

Applied and Environmental Microbiology, 2015-01, Vol.81 (1), p.17-30

2015

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Compensatory evolution of Pseudomonas aeruginosa's slow growth phenotype suggests mechanisms of adaptation in cystic fibrosis

Nature communications, 2021-05, Vol.12 (1), p.3186-15, Article 3186

2021

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Laboratory Evolution to Alternating Substrate Environments Yields Distinct Phenotypic and Genetic Adaptive Strategies

Applied and environmental microbiology, 2017-07, Vol.83 (13)

2017

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Kinetic profiling of metabolic specialists demonstrates stability and consistency of in vivo enzyme turnover numbers

Proceedings of the National Academy of Sciences - PNAS, 2020-09, Vol.117 (37), p.23182-23190

2020

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Multi-omic data integration enables discovery of hidden biological regularities

Nature communications, 2016-10, Vol.7 (1), p.13091-13091, Article 13091

2016

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Genome-scale metabolic reconstructions of multiple Escherichia coli strains highlight strain-specific adaptations to nutritional environments

Proceedings of the National Academy of Sciences - PNAS, 2013-12, Vol.110 (50), p.20338-20343

2013

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Reconstruction of biochemical networks in microorganisms

Nature reviews. Microbiology, 2009-02, Vol.7 (2), p.129-143

2009

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Increased production of L-serine in Escherichia coli through Adaptive Laboratory Evolution

Metabolic engineering, 2017-01, Vol.39, p.141-150

2017

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Adaptive laboratory evolution of tolerance to dicarboxylic acids in Saccharomyces cerevisiae

Metabolic engineering, 2019-12, Vol.56, p.130-141

2019

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BOFdat: Generating biomass objective functions for genome-scale metabolic models from experimental data

PLoS computational biology, 2019-04, Vol.15 (4), p.e1006971-e1006971

2019

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Evolution of Escherichia coli to 42 °C and subsequent genetic engineering reveals adaptive mechanisms and novel mutations

Molecular biology and evolution, 2014-10, Vol.31 (10), p.2647-2662

2014

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Evolution of gene knockout strains of E. coli reveal regulatory architectures governed by metabolism

Nature communications, 2018-09, Vol.9 (1), p.3796-15, Article 3796

2018

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Generation of an atlas for commodity chemical production in Escherichia coli and a novel pathway prediction algorithm, GEM-Path

Metabolic engineering, 2014-09, Vol.25, p.140-158

2014

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Evolution of E. coli on [U-13C]Glucose Reveals a Negligible Isotopic Influence on Metabolism and Physiology

PloS one, 2016-03, Vol.11 (3), p.e0151130-e0151130

2016

Volltextzugriff (PDF)

Advancing the scale of synthetic biology via cross-species transfer of cellular functions enabled by iModulon engraftment

Nature communications, 2024-03, Vol.15 (1), p.2356-2356, Article 2356

2024

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Coupling S-adenosylmethionine-dependent methylation to growth: Design and uses

PLoS biology, 2019-03, Vol.17 (3), p.e2007050-e2007050

2019

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Model-driven discovery of underground metabolic functions in Escherichia coli

Proceedings of the National Academy of Sciences - PNAS, 2015-01, Vol.112 (3), p.929-934

2015

Volltextzugriff (PDF)

MID Max: LC–MS/MS Method for Measuring the Precursor and Product Mass Isotopomer Distributions of Metabolic Intermediates and Cofactors for Metabolic Flux Analysis Applications

Analytical chemistry (Washington), 2016-01, Vol.88 (2), p.1362-1370

2016

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Global Rebalancing of Cellular Resources by Pleiotropic Point Mutations Illustrates a Multi-scale Mechanism of Adaptive Evolution

Cell systems, 2016-04, Vol.2 (4), p.260-271

2016

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The emergence of adaptive laboratory evolution as an efficient tool for biological discovery and industrial biotechnology

Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells

Basic and applied uses of genome‐scale metabolic network reconstructions of Escherichia coli

ALEdb 1.0: a database of mutations from adaptive laboratory evolution experimentation

A Model for Designing Adaptive Laboratory Evolution Experiments

The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coli

Use of adaptive laboratory evolution to discover key mutations enabling rapid growth of Escherichia coli K-12 MG1655 on glucose minimal medium

Compensatory evolution of Pseudomonas aeruginosa's slow growth phenotype suggests mechanisms of adaptation in cystic fibrosis

Laboratory Evolution to Alternating Substrate Environments Yields Distinct Phenotypic and Genetic Adaptive Strategies

Kinetic profiling of metabolic specialists demonstrates stability and consistency of in vivo enzyme turnover numbers

Multi-omic data integration enables discovery of hidden biological regularities

Genome-scale metabolic reconstructions of multiple Escherichia coli strains highlight strain-specific adaptations to nutritional environments

Reconstruction of biochemical networks in microorganisms

Increased production of L-serine in Escherichia coli through Adaptive Laboratory Evolution

Adaptive laboratory evolution of tolerance to dicarboxylic acids in Saccharomyces cerevisiae

BOFdat: Generating biomass objective functions for genome-scale metabolic models from experimental data

Evolution of Escherichia coli to 42 °C and subsequent genetic engineering reveals adaptive mechanisms and novel mutations

Evolution of gene knockout strains of E. coli reveal regulatory architectures governed by metabolism

Generation of an atlas for commodity chemical production in Escherichia coli and a novel pathway prediction algorithm, GEM-Path

Evolution of E. coli on [U-13C]Glucose Reveals a Negligible Isotopic Influence on Metabolism and Physiology

Advancing the scale of synthetic biology via cross-species transfer of cellular functions enabled by iModulon engraftment

Coupling S-adenosylmethionine-dependent methylation to growth: Design and uses

Model-driven discovery of underground metabolic functions in Escherichia coli

MID Max: LC–MS/MS Method for Measuring the Precursor and Product Mass Isotopomer Distributions of Metabolic Intermediates and Cofactors for Metabolic Flux Analysis Applications

Global Rebalancing of Cellular Resources by Pleiotropic Point Mutations Illustrates a Multi-scale Mechanism of Adaptive Evolution

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