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LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse[S]

Journal of lipid research, 2009-12, Vol.50 (12), p.2358-2370

2009

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Identification of Phenylsulfone-Substituted Quinoxaline (WYE-672) as a Tissue Selective Liver X-receptor (LXR) Agonist

Journal of medicinal chemistry, 2010-04, Vol.53 (8), p.3296-3304

2010

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Discovery of Phenyl Acetic Acid Substituted Quinolines as Novel Liver X Receptor Agonists for the Treatment of Atherosclerosis

Journal of medicinal chemistry, 2006-10, Vol.49 (21), p.6151-6154

2006

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Discovery of 6-({4-[2-(4-tert-Butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): An Orally Active Antagonist of the Gonadotropin Releasing Hormone Receptor (GnRH-R)

Journal of medicinal chemistry, 2009-04, Vol.52 (7), p.2148-2152

2009

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Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells

Journal of translational medicine, 2008-10, Vol.6 (1), p.59-59, Article 59

2008

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Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone (GnRH) receptor

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (8), p.2512-2515

2010

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Small molecule antagonists of the gonadotropin-releasing hormone (GnRH) receptor : Structure-activity relationships of small heterocyclic groups appended to the 2-phenyl-4-piperazinyl-benzimidazole template

Bioorganic & medicinal chemistry letters, 2009-04, Vol.19 (7), p.1986-1990

2009

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3-(3-Aryloxyaryl)imidazo[1,2- a]pyridine sulfones as liver X receptor agonists

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.521-525

2010

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Discovery and SAR of cinnolines/quinolines as liver X receptor (LXR) agonists with binding selectivity for LXRβ

Bioorganic & medicinal chemistry, 2009-05, Vol.17 (10), p.3519-3527

2009

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Indazole-Based Liver X Receptor (LXR) Modulators with Maintained Atherosclerotic Lesion Reduction Activity but Diminished Stimulation of Hepatic Triglyceride Synthesis

Journal of medicinal chemistry, 2008-11, Vol.51 (22), p.7161-7168

2008

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1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonists

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.526-530

2010

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Improvement of Physiochemical Properties of the Tetrahydroazepinoindole Series of Farnesoid X Receptor (FXR) Agonists: Beneficial Modulation of Lipids in Primates

Journal of medicinal chemistry, 2010-02, Vol.53 (4), p.1774-1787

2010

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Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRβ and low blood–brain penetration

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.689-693

2010

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Effects of adrenocorticotropic hormone and dexamethasone on adrenal and hepatic α-tocopherol concentrations

Free radical biology & medicine, 1999-03, Vol.26 (5), p.633-638

1999

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Selective Kv1.5 Blockers: Development of (R)-1-(Methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl]-4-(4-methoxyphenyl)-2-imidazolidinone (KVI-020/WYE-160020) as a Potential Treatment for Atrial Arrhythmia

Journal of medicinal chemistry, 2009-11, Vol.52 (21), p.6531-6534

2009

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Synthesis of 4-(3-biaryl)quinoline sulfones as potent liver X receptor agonists

Bioorganic & medicinal chemistry letters, 2010-05, Vol.20 (9), p.2903-2907

2010

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2-Phenyl-4-piperazinylbenzimidazoles: Orally active inhibitors of the gonadotropin releasing hormone (GnRH) receptor

Bioorganic & medicinal chemistry, 2008-07, Vol.16 (13), p.6617-6640

2008

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Further modification on phenyl acetic acid based quinolines as liver X receptor modulators

Bioorganic & medicinal chemistry, 2007-05, Vol.15 (10), p.3321-3333

2007

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Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRb and low blood-brain penetration

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.689-693

2010

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Selective Kv1.5 Blockers: Development of (R)-1-(Methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl-4-(4-methoxyphenyl)-2-imidazolidinone (KVI-020/WYE-160020) as a Potential Treatment for Atrial Arrhythmia

Journal of medicinal chemistry, 2009, Vol.52 (21), p.6531-6534

2009

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Discovery of 6-({4-[2-(4- tert -Butylphenyl)-1 H -benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): An Orally Active Antagonist of the Gonadotropin Releasing Hormone Receptor (GnRH-R)

Journal of medicinal chemistry, 2009-04, Vol.52 (7), p.2148-2152

2009

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Discovery and SAR of cinnolines/quinolines as liver X receptor (LXR) agonists with binding selectivity for LXRbeta

Bioorganic & medicinal chemistry, 2009-05, Vol.17 (10), p.3519-3527

2009

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Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRbeta and low blood-brain penetration

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.689-693

2010

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Regulation of adrenal and hepatic α-tocopherol content by androgens and estrogens

Biochimica et biophysica acta, 1993-03, Vol.1176 (1), p.192-196

1993

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Sex differences in adrenal and hepatic alpha-tocopherol concentrations in rats

Pharmacology, 1992, Vol.44 (2), p.113

1992

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LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse[S]

Identification of Phenylsulfone-Substituted Quinoxaline (WYE-672) as a Tissue Selective Liver X-receptor (LXR) Agonist

Discovery of Phenyl Acetic Acid Substituted Quinolines as Novel Liver X Receptor Agonists for the Treatment of Atherosclerosis

Discovery of 6-({4-[2-(4-tert-Butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): An Orally Active Antagonist of the Gonadotropin Releasing Hormone Receptor (GnRH-R)

Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells

Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone (GnRH) receptor

Small molecule antagonists of the gonadotropin-releasing hormone (GnRH) receptor : Structure-activity relationships of small heterocyclic groups appended to the 2-phenyl-4-piperazinyl-benzimidazole template

3-(3-Aryloxyaryl)imidazo[1,2- a]pyridine sulfones as liver X receptor agonists

Discovery and SAR of cinnolines/quinolines as liver X receptor (LXR) agonists with binding selectivity for LXRβ

Indazole-Based Liver X Receptor (LXR) Modulators with Maintained Atherosclerotic Lesion Reduction Activity but Diminished Stimulation of Hepatic Triglyceride Synthesis

1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonists

Improvement of Physiochemical Properties of the Tetrahydroazepinoindole Series of Farnesoid X Receptor (FXR) Agonists: Beneficial Modulation of Lipids in Primates

Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRβ and low blood–brain penetration

Effects of adrenocorticotropic hormone and dexamethasone on adrenal and hepatic α-tocopherol concentrations

Selective Kv1.5 Blockers: Development of (R)-1-(Methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl]-4-(4-methoxyphenyl)-2-imidazolidinone (KVI-020/WYE-160020) as a Potential Treatment for Atrial Arrhythmia

Synthesis of 4-(3-biaryl)quinoline sulfones as potent liver X receptor agonists

2-Phenyl-4-piperazinylbenzimidazoles: Orally active inhibitors of the gonadotropin releasing hormone (GnRH) receptor

Further modification on phenyl acetic acid based quinolines as liver X receptor modulators

Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRb and low blood-brain penetration

Selective Kv1.5 Blockers: Development of (R)-1-(Methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl-4-(4-methoxyphenyl)-2-imidazolidinone (KVI-020/WYE-160020) as a Potential Treatment for Atrial Arrhythmia

Discovery of 6-({4-[2-(4- tert -Butylphenyl)-1 H -benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): An Orally Active Antagonist of the Gonadotropin Releasing Hormone Receptor (GnRH-R)

Discovery and SAR of cinnolines/quinolines as liver X receptor (LXR) agonists with binding selectivity for LXRbeta

Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRbeta and low blood-brain penetration

Regulation of adrenal and hepatic α-tocopherol content by androgens and estrogens

Sex differences in adrenal and hepatic alpha-tocopherol concentrations in rats

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