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Rodent Modeling of Alzheimer's Disease in Down Syndrome: In vivo and ex vivo Approaches

Frontiers in neuroscience, 2022-06, Vol.16, p.909669-909669

2022

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The presenilin 1 mutation P436S causes familial Alzheimer's disease with elevated Aβ43 and atypical clinical manifestations

Alzheimer's & dementia, 2024-07, Vol.20 (7), p.4717-4726

2024

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Hyper‐sensitive interferon response in a mouse model of Alzheimer’s disease‐Down syndrome

Alzheimer's & dementia, 2023-12, Vol.19 (S13), p.n/a

2023

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Assessing inflammasome activity in mouse models of Down syndrome and organotypic brain slice cultures

Alzheimer's & dementia, 2023-06, Vol.19 (S1), p.n/a

2023

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Interferon hypersensitivity in the brain of a Down syndrome preclinical model

Alzheimer's & dementia, 2022-12, Vol.18 (S4), p.n/a

2022

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Differences in the proteomic profile of the brain in Alzheimer’s disease in Down syndrome and early‐onset Alzheimer’s disease

Alzheimer's & dementia, 2023-12, Vol.19 (S12), p.n/a

2023

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Assessing neuroinflammation and inflammasome activity in mouse models of Down syndrome

Alzheimer's & dementia, 2021-12, Vol.17 (S2), p.e058290-n/a

2021

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Modelling of the development and response to amyloid‐β accumulation in the context of trisomy21 in the rodent brain

Alzheimer's & dementia, 2023-12, Vol.19 (S12), p.n/a

2023

Volltextzugriff (PDF)

Quantification of substoichiometric modification reveals global tsRNA hypomodification, preferences for angiogenin-mediated tRNA cleavage, and idiosyncratic epitranscriptomes of human neuronal cell-lines

Computational and structural biotechnology journal, 2023-01, Vol.21, p.401-417

2023

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Integrated analysis of transcriptomic and proteomic alterations in mouse models of ALS/FTD identify early metabolic adaptions with similarities to mitochondrial dysfunction disorders

Amyotrophic lateral sclerosis and frontotemporal degeneration, 2024-02, Vol.25 (1-2), p.135-149

2024

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Retrospective cross-sectional analysis of concurrent VTE diagnosis in hospitalised socially excluded individuals in Ireland

BMJ open, 2024-01, Vol.14 (1), p.e073718-e073718

2024

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Towards a consensus definition of allostatic load: a multi-cohort, multi-system, multi-biomarker individual participant data (IPD) meta-analysis

Psychoneuroendocrinology, 2023-07, Vol.153, p.106117-106117, Article 106117

2023

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Recurrent large genomic rearrangements in BRCA1 and BRCA2 in an Irish case series

Cancer genetics, 2017-08, Vol.214, p.1-8

2017

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Structure and function of the Epstein-Barr virus BZLF1 protein

Journal of Virology, 1990-05, Vol.64 (5), p.2110-2116

1990

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Host cell and EBNA-2 regulation of Epstein-Barr virus latent-cycle promoter activity in B lymphocytes

Journal of Virology, 1992-01, Vol.66 (1), p.496-504

1992

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Rodent Modeling of Alzheimer's Disease in Down Syndrome: In vivo and ex vivo Approaches

The presenilin 1 mutation P436S causes familial Alzheimer's disease with elevated Aβ43 and atypical clinical manifestations

Hyper‐sensitive interferon response in a mouse model of Alzheimer’s disease‐Down syndrome

Assessing inflammasome activity in mouse models of Down syndrome and organotypic brain slice cultures

Interferon hypersensitivity in the brain of a Down syndrome preclinical model

Differences in the proteomic profile of the brain in Alzheimer’s disease in Down syndrome and early‐onset Alzheimer’s disease

Assessing neuroinflammation and inflammasome activity in mouse models of Down syndrome

Modelling of the development and response to amyloid‐β accumulation in the context of trisomy21 in the rodent brain

Quantification of substoichiometric modification reveals global tsRNA hypomodification, preferences for angiogenin-mediated tRNA cleavage, and idiosyncratic epitranscriptomes of human neuronal cell-lines

Integrated analysis of transcriptomic and proteomic alterations in mouse models of ALS/FTD identify early metabolic adaptions with similarities to mitochondrial dysfunction disorders

Retrospective cross-sectional analysis of concurrent VTE diagnosis in hospitalised socially excluded individuals in Ireland

Towards a consensus definition of allostatic load: a multi-cohort, multi-system, multi-biomarker individual participant data (IPD) meta-analysis

Recurrent large genomic rearrangements in BRCA1 and BRCA2 in an Irish case series

Structure and function of the Epstein-Barr virus BZLF1 protein

Host cell and EBNA-2 regulation of Epstein-Barr virus latent-cycle promoter activity in B lymphocytes

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