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Parkinson’s disease: proteinopathy or lipidopathy?

NPJ Parkinson's Disease, 2020-01, Vol.6 (1), p.3-9, Article 3

2020

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Fungal biofilms

PLoS pathogens, 2012-04, Vol.8 (4), p.e1002585-e1002585

2012

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Vesicle trafficking and lipid metabolism in synucleinopathy

Acta neuropathologica, 2021-04, Vol.141 (4), p.491-510

2021

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Bifidobacterial surface-exopolysaccharide facilitates commensal-host interaction through immune modulation and pathogen protection

Proceedings of the National Academy of Sciences - PNAS, 2012-02, Vol.109 (6), p.2108-2113

2012

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Lipotoxicity Downstream of α-Synuclein Imbalance: A Relevant Pathomechanism in Synucleinopathies?

Biomolecules (Basel, Switzerland), 2021-12, Vol.12 (1), p.40

2021

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Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity

Cell, 2018-03, Vol.173 (1), p.62-73.e9

2018

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Divergent Targets of Candida albicans Biofilm Regulator Bcr1 In Vitro and In Vivo

Eukaryotic Cell, 2012-07, Vol.11 (7), p.896-904

2012

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Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor

International journal of molecular sciences, 2020-07, Vol.21 (15), p.5193

2020

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An extensive circuitry for cell wall regulation in Candida albicans

PLoS pathogens, 2010-02, Vol.6 (2), p.e1000752-e1000752

2010

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Bifidobacterium breve UCC2003 surface exopolysaccharide production is a beneficial trait mediating commensal-host interaction through immune modulation and pathogen protection

Gut microbes, 2012-09, Vol.3 (5), p.420-425

2012

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Candida albicans Czf1 and Efg1 Coordinate the Response to Farnesol during Quorum Sensing, White-Opaque Thermal Dimorphism, and Cell Death

Eukaryotic Cell, 2013-09, Vol.12 (9), p.1281-1292

2013

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Interaction between the Candida albicans High-Osmolarity Glycerol (HOG) Pathway and the Response to Human β-Defensins 2 and 3

Eukaryotic Cell, 2011-02, Vol.10 (2), p.272-275

2011

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Regulatory role of glycerol in Candida albicans biofilm formation

mBio, 2013-04, Vol.4 (2), p.e00637

2013

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Lipase regulation of cellular fatty acid homeostasis as a Parkinson’s disease therapeutic strategy

NPJ Parkinson's Disease, 2022-06, Vol.8 (1), p.74-74, Article 74

2022

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Pathogenic Mechanisms of Cytosolic and Membrane-Enriched α-Synuclein Converge on Fatty Acid Homeostasis

The Journal of neuroscience, 2022-03, Vol.42 (10), p.2116-2130

2022

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Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase

Proceedings of the National Academy of Sciences - PNAS, 2019-10, Vol.116 (41), p.20760-20769

2019

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A Stearoyl–Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α‐Synuclein Mice

Annals of neurology, 2021-01, Vol.89 (1), p.74-90

2021

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Studying α-Synuclein Conformation by Intact-Cell Cross-Linking

Methods in molecular biology (Clifton, N.J.), 2019, Vol.1948, p.77

2019

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Excess membrane binding of monomeric alpha-, beta- and gamma-synuclein is invariably associated with inclusion formation and toxicity

Human molecular genetics, 2021-11, Vol.30 (23), p.2332-2346

2021

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Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells

Human molecular genetics, 2017-09, Vol.26 (18), p.3466-3481

2017

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FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome

Proceedings of the National Academy of Sciences - PNAS, 2017-12, Vol.114 (52), p.E11313-E11322

2017

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Parkinson's disease: proteinopathy or lipidopathy?

NPJ Parkinson's Disease, 2020-01, Vol.6 (1), p.3

2020

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A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity

Neurotherapeutics, 2022-04, Vol.19 (3), p.1018-1036

2022

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Correction to: A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity

Neurotherapeutics, 2022-07, Vol.19 (4), p.1434-1434

2022

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Parkinson’s disease: proteinopathy or lipidopathy?

Fungal biofilms

Vesicle trafficking and lipid metabolism in synucleinopathy

Bifidobacterial surface-exopolysaccharide facilitates commensal-host interaction through immune modulation and pathogen protection

Lipotoxicity Downstream of α-Synuclein Imbalance: A Relevant Pathomechanism in Synucleinopathies?

Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity

Divergent Targets of Candida albicans Biofilm Regulator Bcr1 In Vitro and In Vivo

Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor

An extensive circuitry for cell wall regulation in Candida albicans

Bifidobacterium breve UCC2003 surface exopolysaccharide production is a beneficial trait mediating commensal-host interaction through immune modulation and pathogen protection

Candida albicans Czf1 and Efg1 Coordinate the Response to Farnesol during Quorum Sensing, White-Opaque Thermal Dimorphism, and Cell Death

Interaction between the Candida albicans High-Osmolarity Glycerol (HOG) Pathway and the Response to Human β-Defensins 2 and 3

Regulatory role of glycerol in Candida albicans biofilm formation

Lipase regulation of cellular fatty acid homeostasis as a Parkinson’s disease therapeutic strategy

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

Pathogenic Mechanisms of Cytosolic and Membrane-Enriched α-Synuclein Converge on Fatty Acid Homeostasis

Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase

A Stearoyl–Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α‐Synuclein Mice

Studying α-Synuclein Conformation by Intact-Cell Cross-Linking

Excess membrane binding of monomeric alpha-, beta- and gamma-synuclein is invariably associated with inclusion formation and toxicity

Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells

FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome

Parkinson's disease: proteinopathy or lipidopathy?

A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity

Correction to: A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity

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