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Structure Modification of FXR Antagonistic Chalcones and Their Inhibitory Effects on NSCLC Cell Proliferation and Metastasis

ChemMedChem, 2022-06, Vol.17 (11), p.e202100778-n/a

2022

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Taxanes convert regions of perturbed microtubule growth into rescue sites

Nature materials, 2020-03, Vol.19 (3), p.355-365

2020

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Targeting the tubulin C-terminal tail by charged small molecules

Organic & biomolecular chemistry, 2022-12, Vol.21 (1), p.153-162

2022

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Structural insight into the stabilization of microtubules by taxanes

eLife, 2023-03, Vol.12

2023

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Extensive Structure Modification on Luteolin-Cinnamic Acid Conjugates Leading to BACE1 Inhibitors with Optimal Pharmacological Properties

Molecules (Basel, Switzerland), 2019-12, Vol.25 (1), p.102

2019

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Synthesis and Cytotoxicity of 7,9- O -Linked Macrocyclic C-Seco Taxoids

Molecules (Basel, Switzerland), 2019-06, Vol.24 (11), p.2161

2019

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Pentacyclic triterpenoids and their saponins with apoptosis-inducing activity

Current topics in medicinal chemistry, 2009-11, Vol.9 (16), p.1581

2009

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Medicinal Chemistry of Bioactive Natural Products

1. Aufl., 2006

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Discovery of Farnesoid X Receptor Antagonists Based on a Library of Oleanolic Acid 3-O-Esters through Diverse Substituent Design and Molecular Docking Methods

Molecules (Basel, Switzerland), 2017-04, Vol.22 (5), p.690

2017

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Lx2-32c-loaded polymeric micelles with small size for intravenous drug delivery and their inhibitory effect on tumor growth and metastasis in clinically associated 4T1 murine breast cancer

International journal of nanomedicine, 2016-01, Vol.11, p.5457-5472

2016

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A structure-based design of new C2- and C13-substituted taxanes: tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysis

Organic & biomolecular chemistry, 2013-05, Vol.11 (18), p.3046-3056

2013

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Modulation of taxane binding to tubulin curved and straight conformations by systematic 3′N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potency

European journal of medicinal chemistry, 2023-11, Vol.259, p.115668, Article 115668

2023

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Discovery of 12β-oxygenated oleanolic acid alkyl esters as potent and selective FXR modulators exhibiting hyperglycemia amelioration in vivo

Bioorganic chemistry, 2022-12, Vol.129, p.106203-106203, Article 106203

2022

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A Series of Enthalpically Optimized Docetaxel Analogues Exhibiting Enhanced Antitumor Activity and Water Solubility

Journal of natural products (Washington, D.C.), 2018-03, Vol.81 (3), p.524-533

2018

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On the Chemical Constituents of Dipsacus asper

Chemical and Pharmaceutical Bulletin, 2007/12/01, Vol.55(12), pp.1677-1681

2007

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A semisynthetic taxane Yg-3-46a effectively evades P-glycoprotein and β-III tubulin mediated tumor drug resistance in vitro

Cancer letters, 2013-12, Vol.341 (2), p.214-223

2013

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Synthesis and Biological Evaluations of Cytotoxic and Antiangiogenic Triterpenoids-Jacaranone Conjugates

Medicinal chemistry (Shp-sariqah, United Arab Emirates), 2016-12, Vol.12 (8), p.775

2016

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BACE1 (Beta-Secretase) Inhibitory Phenolic Acids and a Novel Sesquiterpenoid from Homalomena occulta

Chemistry & biodiversity, 2010-04, Vol.7 (4), p.984-992

2010

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Synthesis and biological activities of high affinity taxane-based fluorescent probes

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.751-754

2009

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Discovery of a series of selective and cell permeable beta-secretase (BACE1) inhibitors by fragment linking with the assistance of STD-NMR

Bioorganic chemistry, 2019-11, Vol.92, p.103253-103253, Article 103253

2019

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Modification of C-seco taxoids through ring tethering and substituent replacement leading to effective agents against tumor drug resistance mediated by βIII-Tubulin and P-glycoprotein (P-gp) overexpressions

European journal of medicinal chemistry, 2017-09, Vol.137, p.488-503

2017

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Overcoming Tumor Drug Resistance with High-Affinity Taxanes: A SAR Study of C2-Modified 7-Acyl-10-Deacetyl Cephalomannines

ChemMedChem, 2007-05, Vol.2 (5), p.691-701

2007

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Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances

Bioorganic & medicinal chemistry, 2014-09, Vol.22 (18), p.5078-5090

2014

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Biotransformation of 3-oxo-oleanolic acid by Absidia glauca

Planta medica, 2010-11, Vol.76 (16), p.1904

2010

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A novel C,D-spirodioxene taxoid synthesized through an unexpected Pd-mediated ring cyclization

Organic & biomolecular chemistry, 2016-01, Vol.14 (1), p.345-352

2016

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Structure Modification of FXR Antagonistic Chalcones and Their Inhibitory Effects on NSCLC Cell Proliferation and Metastasis

Taxanes convert regions of perturbed microtubule growth into rescue sites

Targeting the tubulin C-terminal tail by charged small molecules

Structural insight into the stabilization of microtubules by taxanes

Extensive Structure Modification on Luteolin-Cinnamic Acid Conjugates Leading to BACE1 Inhibitors with Optimal Pharmacological Properties

Synthesis and Cytotoxicity of 7,9- O -Linked Macrocyclic C-Seco Taxoids

Pentacyclic triterpenoids and their saponins with apoptosis-inducing activity

Medicinal Chemistry of Bioactive Natural Products

Discovery of Farnesoid X Receptor Antagonists Based on a Library of Oleanolic Acid 3-O-Esters through Diverse Substituent Design and Molecular Docking Methods

Lx2-32c-loaded polymeric micelles with small size for intravenous drug delivery and their inhibitory effect on tumor growth and metastasis in clinically associated 4T1 murine breast cancer

A structure-based design of new C2- and C13-substituted taxanes: tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysis

Modulation of taxane binding to tubulin curved and straight conformations by systematic 3′N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potency

Discovery of 12β-oxygenated oleanolic acid alkyl esters as potent and selective FXR modulators exhibiting hyperglycemia amelioration in vivo

A Series of Enthalpically Optimized Docetaxel Analogues Exhibiting Enhanced Antitumor Activity and Water Solubility

On the Chemical Constituents of Dipsacus asper

A semisynthetic taxane Yg-3-46a effectively evades P-glycoprotein and β-III tubulin mediated tumor drug resistance in vitro

Synthesis and Biological Evaluations of Cytotoxic and Antiangiogenic Triterpenoids-Jacaranone Conjugates

BACE1 (Beta-Secretase) Inhibitory Phenolic Acids and a Novel Sesquiterpenoid from Homalomena occulta

Synthesis and biological activities of high affinity taxane-based fluorescent probes

Discovery of a series of selective and cell permeable beta-secretase (BACE1) inhibitors by fragment linking with the assistance of STD-NMR

Modification of C-seco taxoids through ring tethering and substituent replacement leading to effective agents against tumor drug resistance mediated by βIII-Tubulin and P-glycoprotein (P-gp) overexpressions

Overcoming Tumor Drug Resistance with High-Affinity Taxanes: A SAR Study of C2-Modified 7-Acyl-10-Deacetyl Cephalomannines

Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances

Biotransformation of 3-oxo-oleanolic acid by Absidia glauca

A novel C,D-spirodioxene taxoid synthesized through an unexpected Pd-mediated ring cyclization

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