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Phosphorylation of SDT Repeats in the MDC1 N Terminus Triggers Retention of NBS1 at the DNA Damage-Modified Chromatin

The Journal of cell biology, 2008-04, Vol.181 (2), p.213-226

2008

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CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination

EMBO reports, 2012-06, Vol.13 (6), p.561-568

2012

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Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

Nature cell biology, 2003-03, Vol.5 (3), p.255-260

2003

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The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

Nature (London), 2001-04, Vol.410 (6830), p.842-847

2001

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Rapid Destruction of Human Cdc25A in Response to DNA Damage

Science (American Association for the Advancement of Science), 2000-05, Vol.288 (5470), p.1425-1429

2000

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Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities

The Journal of cell biology, 2009-09, Vol.186 (5), p.655-663

2009

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Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent Phosphorylation of Chk1 on Ser-317 in Response to Ionizing Radiation

The Journal of biological chemistry, 2003-04, Vol.278 (17), p.14806-14811

2003

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Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation

Oncogene, 2004-04, Vol.23 (17), p.3122-3127

2004

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Involvement of Myc Activity in a G1/S-Promoting Mechanism Parallel to the pRb/E2F Pathway

Molecular and Cellular Biology, 2000-05, Vol.20 (10), p.3497-3509

2000

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HCLK2 Is Required for Activity of the DNA Damage Response Kinase ATR

The Journal of biological chemistry, 2009-02, Vol.284 (7), p.4140-4147

2009

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

Nature, 2005-03, Vol.434 (7033), p.605-611

2005

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Alternative splicing and mutation status of CHEK2 in stage III breast cancer

Oncogene, 2004-11, Vol.23 (52), p.8535-8544

2004

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

Nature cell biology, 2006-01, Vol.8 (1), p.37-45

2006

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Chk2 kinase - a busy messenger

Nature reviews. Molecular cell biology, 2001-12, Vol.2 (12), p.877-886

2001

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Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

The EMBO journal, 2004-07, Vol.23 (13), p.2674-2683

2004

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MDC1 is required for the intra-S-phase DNA damage checkpoint

Nature (London), 2003-02, Vol.421 (6926), p.952-956

2003

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Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A

Cancer cell, 2003-03, Vol.3 (3), p.247-258

2003

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The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways

Nature genetics, 2002-03, Vol.30 (3), p.290-294

2002

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Differential Cytotoxic Pathways of Topoisomerase I and II Anticancer Agents after Overexpression of the E2F-1/DP-1 Transcription Factor Complex

Clinical cancer research, 2000-04, Vol.6 (4), p.1488-1497

2000

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CHEK2 variant I157T may be associated with increased breast cancer risk

International journal of cancer, 2004-09, Vol.111 (4), p.543-547

2004

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DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology

Cancer research (Chicago, Ill.), 2001-07, Vol.61 (13), p.4990-4993

2001

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Differential impact of diverse anticancer chemotherapeutics on the Cdc25A-degradation checkpoint pathway

Experimental cell research, 2005-01, Vol.302 (2), p.162-169

2005

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Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway

Oncogene, 2001-09, Vol.20 (39), p.5503-5510

2001

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Human Fbh 1 Helicase Contributes to Genome Maintenance via Pro- and Anti-Recombinase Activities

The Journal of cell biology, 2009-09, Vol.186 (5), p.655-663

2009

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Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours

Oncogene, 2001-09, Vol.20 (41), p.5897-5902

2001

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Phosphorylation of SDT Repeats in the MDC1 N Terminus Triggers Retention of NBS1 at the DNA Damage-Modified Chromatin

CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination

Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

Rapid Destruction of Human Cdc25A in Response to DNA Damage

Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities

Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent Phosphorylation of Chk1 on Ser-317 in Response to Ionizing Radiation

Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation

Involvement of Myc Activity in a G1/S-Promoting Mechanism Parallel to the pRb/E2F Pathway

HCLK2 Is Required for Activity of the DNA Damage Response Kinase ATR

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

Alternative splicing and mutation status of CHEK2 in stage III breast cancer

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

Chk2 kinase - a busy messenger

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

MDC1 is required for the intra-S-phase DNA damage checkpoint

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A

The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways

Differential Cytotoxic Pathways of Topoisomerase I and II Anticancer Agents after Overexpression of the E2F-1/DP-1 Transcription Factor Complex

CHEK2 variant I157T may be associated with increased breast cancer risk

DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology

Differential impact of diverse anticancer chemotherapeutics on the Cdc25A-degradation checkpoint pathway

Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway

Human Fbh 1 Helicase Contributes to Genome Maintenance via Pro- and Anti-Recombinase Activities

Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours

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