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Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis

Current medicinal chemistry, 2019-01, Vol.26 (23), p.4454

2019

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Drug Resistance in Leishmaniasis

Clinical Microbiology Reviews, 2006-01, Vol.19 (1), p.111-126

2006

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Validation of Trypanosoma cruzi inactivation techniques for laboratory use

PloS one, 2024-04, Vol.19 (4), p.e0300021-e0300021

2024

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Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania

PLoS pathogens, 2016-11, Vol.12 (11), p.e1005971-e1005971

2016

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Chemotherapy of human African trypanosomiasis: current and future prospects

Trends in parasitology, 2003-11, Vol.19 (11), p.488-494

Fairlamb, Alan H.

2003

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Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

Antimicrobial Agents and Chemotherapy, 2013-07, Vol.57 (7), p.2913-2922

2013

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Assessing the Essentiality of Leishmania donovani Nitroreductase and Its Role in Nitro Drug Activation

Antimicrobial Agents and Chemotherapy, 2013-02, Vol.57 (2), p.901-906

2013

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The critical role of mode of action studies in kinetoplastid drug discovery

Frontiers in drug discovery, 2023-05, Vol.3

2023

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Melarsoprol Resistance in African Trypanosomiasis

Trends in parasitology, 2018-06, Vol.34 (6), p.481-492

2018

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Target validation: linking target and chemical properties to desired product profile

Current topics in medicinal chemistry, 2011-05, Vol.11 (10), p.1275

2011

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Chronic exposure to arsenic in drinking water can lead to resistance to antimonial drugs in a mouse model of visceral leishmaniasis

Proceedings of the National Academy of Sciences - PNAS, 2013-12, Vol.110 (49), p.19932-19937

2013

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Norspermidine Is Not a Self-Produced Trigger for Biofilm Disassembly

Cell, 2014-02, Vol.156 (4), p.844-854

2014

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N -myristoyltransferase inhibitors as new leads to treat sleeping sickness

Nature, 2010-04, Vol.464 (7289), p.728-732

2010

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Dual Action of Antimonial Drugs on Thiol Redox Metabolism in the Human Pathogen Leishmania donovani

The Journal of biological chemistry, 2004-09, Vol.279 (38), p.39925-39932

2004

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Drug resistance in eukaryotic microorganisms

Nature microbiology, 2016-06, Vol.1 (7), p.16092

2016

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Allosteric Activation of Trypanosomatid Deoxyhypusine Synthase by a Catalytically Dead Paralog

The Journal of biological chemistry, 2013-05, Vol.288 (21), p.15256-15267

2013

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The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

eLife, 2016-05, Vol.5

2016

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Cross-Resistance to Nitro Drugs and Implications for Treatment of Human African Trypanosomiasis

Antimicrobial Agents and Chemotherapy, 2010-07, Vol.54 (7), p.2893-2900

2010

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Arsenic exposure and outcomes of antimonial treatment in visceral leishmaniasis patients in Bihar, India: a retrospective cohort study

PLoS neglected tropical diseases, 2015-03, Vol.9 (3), p.e0003518

2015

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Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome

PLoS neglected tropical diseases, 2015-12, Vol.9 (12), p.e0004299-e0004299

2015

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The R Enantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis

Antimicrobial Agents and Chemotherapy, 2013-10, Vol.57 (10), p.4699-4706

2013

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Trypanosoma brucei DHFR-TS Revisited: Characterisation of a Bifunctional and Highly Unstable Recombinant Dihydrofolate Reductase-Thymidylate Synthase

PLoS neglected tropical diseases, 2016-05, Vol.10 (5), p.e0004714-e0004714

2016

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Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase

Biochemical journal, 2014-04, Vol.459 (2), p.323-332

2014

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Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods

Molecular microbiology, 2009-11, Vol.74 (3), p.529-540

2009

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Roles of Trypanothione S-Transferase and Tryparedoxin Peroxidase in Resistance to Antimonials

Antimicrobial Agents and Chemotherapy, 2008-04, Vol.52 (4), p.1359-1365

2008

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Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis

Drug Resistance in Leishmaniasis

Validation of Trypanosoma cruzi inactivation techniques for laboratory use

Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania

Chemotherapy of human African trypanosomiasis: current and future prospects

Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

Assessing the Essentiality of Leishmania donovani Nitroreductase and Its Role in Nitro Drug Activation

The critical role of mode of action studies in kinetoplastid drug discovery

Melarsoprol Resistance in African Trypanosomiasis

Target validation: linking target and chemical properties to desired product profile

Chronic exposure to arsenic in drinking water can lead to resistance to antimonial drugs in a mouse model of visceral leishmaniasis

Norspermidine Is Not a Self-Produced Trigger for Biofilm Disassembly

N -myristoyltransferase inhibitors as new leads to treat sleeping sickness

Dual Action of Antimonial Drugs on Thiol Redox Metabolism in the Human Pathogen Leishmania donovani

Drug resistance in eukaryotic microorganisms

Allosteric Activation of Trypanosomatid Deoxyhypusine Synthase by a Catalytically Dead Paralog

The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

Cross-Resistance to Nitro Drugs and Implications for Treatment of Human African Trypanosomiasis

Arsenic exposure and outcomes of antimonial treatment in visceral leishmaniasis patients in Bihar, India: a retrospective cohort study

Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome

The R Enantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis

Trypanosoma brucei DHFR-TS Revisited: Characterisation of a Bifunctional and Highly Unstable Recombinant Dihydrofolate Reductase-Thymidylate Synthase

Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase

Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods

Roles of Trypanothione S-Transferase and Tryparedoxin Peroxidase in Resistance to Antimonials

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