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Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological characterization and broad preclinical efficacy in cognition and schizophrenia of a potent and selective histamine H3 receptor antagonist

The Journal of pharmacology and experimental therapeutics, 2005-04, Vol.313 (1), p.176

2005

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4-(2-[2-(2(R)-Methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and Related 2-Aminoethylbenzofuran H3 Receptor Antagonists Potently Enhance Cognition and Attention

Journal of medicinal chemistry, 2005-01, Vol.48 (1), p.38-55

2005

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Discovery of 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a Novel Positive Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor

Journal of medicinal chemistry, 2009-05, Vol.52 (10), p.3377-3384

2009

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Two novel and selective nonimidazole H3 receptor antagonists A-304121 and A-317920: II. In vivo behavioral and neurophysiological characterization

The Journal of pharmacology and experimental therapeutics, 2003-06, Vol.305 (3), p.897

2003

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Medicinal chemistry and biological properties of non-imidazole histamine H3 antagonists

Mini reviews in medicinal chemistry, 2004-11, Vol.4 (9), p.979

2004

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Effects of histamine H3 receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup

Behavioural brain research, 2002-04, Vol.131 (1-2), p.151-161

2002

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Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects

The Journal of pharmacology and experimental therapeutics, 2003-06, Vol.305 (3), p.887

2003

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Structure–activity relationships of arylbenzofuran H3 receptor antagonists

Bioorganic & medicinal chemistry letters, 2005-05, Vol.15 (10), p.2559-2563

2005

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Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist

Biochemical pharmacology, 2004-09, Vol.68 (5), p.933-945

2004

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Novel heterocyclic-substituted benzofuran histamine H3 receptor antagonists: in vitro properties, drug-likeness, and behavioral activity

Biochemical pharmacology, 2007-04, Vol.73 (8), p.1243-1255

2007

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Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: Novel and selective histamine H3 receptor antagonists

Bioorganic & medicinal chemistry letters, 2003-04, Vol.13 (7), p.1325-1328

2003

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Allosteric Modulators of the α7 Nicotinic Acetylcholine Receptor

Journal of medicinal chemistry, 2008-02, Vol.51 (4), p.701-712

2008

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Differential in vivo effects of H3 receptor ligands in a new mouse dipsogenia model

Pharmacology, biochemistry and behavior, 2002-06, Vol.72 (3), p.741-750

2002

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Detection of multiple H3 receptor affinity states utilizing [3H]A‐349821, a novel, selective, non‐imidazole histamine H3 receptor inverse agonist radioligand

British journal of pharmacology, 2006-07, Vol.148 (5), p.657-670

2006

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In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile

The Journal of pharmacology and experimental therapeutics, 2009-07, Vol.330 (1), p.257

2009

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Synthesis and Structure−Activity Relationships of 2-Pyridones: A Novel Series of Potent DNA Gyrase Inhibitors as Antibacterial Agents

Journal of medicinal chemistry, 1996-08, Vol.39 (16), p.3070-3088

1996

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Effect of novel motilide ABT-229 versus erythromycin and cisapride on gastric emptying in dogs

The Journal of pharmacology and experimental therapeutics, 2000-06, Vol.293 (3), p.1106

2000

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4-(2-[2-(2( R )-Methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and Related 2-Aminoethylbenzofuran H 3 Receptor Antagonists Potently Enhance Cognition and Attention

Journal of medicinal chemistry, 2005-01, Vol.48 (1), p.38-55

2005

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Allosteric modulators of the alpha7 nicotinic acetylcholine receptor

Journal of medicinal chemistry, 2008-02, Vol.51 (4), p.701-712

2008

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Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist

European journal of pharmacology, 2004-03, Vol.487 (1-3), p.183-197

2004

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Synthesis and SAR of 5-Amino- and 5-(Aminomethyl)benzofuran Histamine H 3 Receptor Antagonists with Improved Potency

Journal of medicinal chemistry, 2005-10, Vol.48 (20), p.6482-6490

2005

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Correction to Synthesis and SAR of 5-Amino- and 5-(Aminomethyl)benzofuran Histamine H 3 Receptor Antagonists with Improved Potency

Journal of medicinal chemistry, 2012-01, Vol.55 (1), p.563-563

2012

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Antiobesity effects of A-331440, a novel non-imidazole histamine H 3 receptor antagonist

European journal of pharmacology, 2004-03, Vol.487 (1), p.183-197

2004

Volltextzugriff (PDF)

Synthesis and SAR of 5-Amino- and 5-(Aminomethyl)benzofuran Histamine H3 Receptor Antagonists with Improved Potency

Journal of medicinal chemistry, 2005-10, Vol.48 (20), p.6482-6490

2005

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Lack of cataleptogenic potentiation with non-imidazole H 3 receptor antagonists reveals potential drug–drug interactions between imidazole-based H 3 receptor antagonists and antipsychotic drugs

Brain research, 2005-05, Vol.1045 (1), p.142-149

2005

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Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological characterization and broad preclinical efficacy in cognition and schizophrenia of a potent and selective histamine H3 receptor antagonist

4-(2-[2-(2(R)-Methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and Related 2-Aminoethylbenzofuran H3 Receptor Antagonists Potently Enhance Cognition and Attention

Discovery of 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a Novel Positive Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor

Two novel and selective nonimidazole H3 receptor antagonists A-304121 and A-317920: II. In vivo behavioral and neurophysiological characterization

Medicinal chemistry and biological properties of non-imidazole histamine H3 antagonists

Effects of histamine H3 receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup

Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects

Structure–activity relationships of arylbenzofuran H3 receptor antagonists

Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist

Novel heterocyclic-substituted benzofuran histamine H3 receptor antagonists: in vitro properties, drug-likeness, and behavioral activity

Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: Novel and selective histamine H3 receptor antagonists

Allosteric Modulators of the α7 Nicotinic Acetylcholine Receptor

Differential in vivo effects of H3 receptor ligands in a new mouse dipsogenia model

Detection of multiple H3 receptor affinity states utilizing [3H]A‐349821, a novel, selective, non‐imidazole histamine H3 receptor inverse agonist radioligand

In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile

Synthesis and Structure−Activity Relationships of 2-Pyridones: A Novel Series of Potent DNA Gyrase Inhibitors as Antibacterial Agents

Effect of novel motilide ABT-229 versus erythromycin and cisapride on gastric emptying in dogs

4-(2-[2-(2( R )-Methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and Related 2-Aminoethylbenzofuran H 3 Receptor Antagonists Potently Enhance Cognition and Attention

Allosteric modulators of the alpha7 nicotinic acetylcholine receptor

Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist

Synthesis and SAR of 5-Amino- and 5-(Aminomethyl)benzofuran Histamine H 3 Receptor Antagonists with Improved Potency

Correction to Synthesis and SAR of 5-Amino- and 5-(Aminomethyl)benzofuran Histamine H 3 Receptor Antagonists with Improved Potency

Antiobesity effects of A-331440, a novel non-imidazole histamine H 3 receptor antagonist

Synthesis and SAR of 5-Amino- and 5-(Aminomethyl)benzofuran Histamine H3 Receptor Antagonists with Improved Potency

Lack of cataleptogenic potentiation with non-imidazole H 3 receptor antagonists reveals potential drug–drug interactions between imidazole-based H 3 receptor antagonists and antipsychotic drugs

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