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1400W Is a Slow, Tight Binding, and Highly Selective Inhibitor of Inducible Nitric-oxide Synthase in Vitro and in Vivo

The Journal of biological chemistry, 1997-02, Vol.272 (8), p.4959-4963

1997

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Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas

The Journal of biological chemistry, 1994-10, Vol.269 (43), p.26669-26676

1994

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Preclinical Pharmacology and Pharmacokinetics of GW433908, a Water-Soluble Prodrug of the Human Immunodeficiency Virus Protease Inhibitor Amprenavir

Antimicrobial Agents and Chemotherapy, 2004-03, Vol.48 (3), p.791-798

2004

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Metabolic complications associated with antiretroviral therapy

Antiviral Research, 2001-09, Vol.51 (3), p.151-177

2001

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N-Phenylamidines as Selective Inhibitors of Human Neuronal Nitric Oxide Synthase: Structure−Activity Studies and Demonstration of in Vivo Activity

Journal of medicinal chemistry, 1998-07, Vol.41 (15), p.2858-2871

1998

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Potent and selective inhibition of human nitric oxide synthases. Selective inhibition of neuronal nitric oxide synthase by S-methyl-L-thiocitrulline and S-ethyl-L-thiocitrulline

The Journal of biological chemistry, 1994-10, Vol.269 (43), p.26677-26683

1994

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HIV protease inhibitors block adipogenesis and increase lipolysis in vitro

Antiviral research, 2000-08, Vol.47 (2), p.121-129

2000

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Substituted N-Phenylisothioureas: Potent Inhibitors of Human Nitric Oxide Synthase with Neuronal Isoform Selectivity

Journal of medicinal chemistry, 1997-06, Vol.40 (12), p.1901-1905

1997

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Novel inhibitors of HIV protease : Design, synthesis and biological evaluation of picomolar inhibitors containing cyclic P1/P2 scaffolds

Bioorganic & medicinal chemistry letters, 2000-06, Vol.10 (11), p.1159-1162

2000

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Reverse transcriptase.RNase H from the human immunodeficiency virus. Relationship of the DNA polymerase and RNA hydrolysis activities

The Journal of biological chemistry, 1991-01, Vol.266 (1), p.406-412

1991

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Dietary Fat Alters HIV Protease Inhibitor–Induced Metabolic Changes in Mice

The Journal of nutrition, 2000-09, Vol.130 (9), p.2361-2366

2000

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Biochemical studies on the reverse transcriptase and RNase H activities from human immunodeficiency virus strains resistant to 3'-azido-3'-deoxythymidine

The Journal of biological chemistry, 1992-08, Vol.267 (22), p.15789-15794

1992

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Effectors of HIV-1 Protease Peptidolytic Activity

Biochemistry (Easton), 2001-09, Vol.40 (37), p.11131-11139

2001

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Substrate Binding Is Required for Release of Product from Mammalian Protein Farnesyltransferase

The Journal of biological chemistry, 1997-04, Vol.272 (15), p.9989-9993

1997

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Human immunodeficiency virus. Mutations in the viral protease that confer resistance to saquinavir increase the dissociation rate constant of the protease-saquinavir complex

The Journal of biological chemistry, 1996-12, Vol.271 (52), p.33231-33235

1996

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Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release

Biochemistry (Easton), 1995-05, Vol.34 (20), p.6857-6862

1995

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Analysis of resistance to human immunodeficiency virus type 1 protease inhibitors by using matched bacterial expression and proviral infection vectors

Journal of Virology, 1995-09, Vol.69 (9), p.5431-5436

1995

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Stimulation of vitamin A(1) acid signaling by the HIV protease inhibitor indinavir

Biochemical pharmacology, 2000-05, Vol.59 (9), p.1063

2000

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Inhibition of Wild-Type and Mutant Human Immunodeficiency Virus Type 1 Proteases by GW0385 and Other Arylsulfonamides

Biochemistry (Easton), 2004-11, Vol.43 (45), p.14500-14507

2004

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Changes in Human Immunodeficiency Virus Type 1 Gag at Positions L449 and P453 Are Linked to I50V Protease Mutants In Vivo and Cause Reduction of Sensitivity to Amprenavir and Improved Viral Fitness In Vitro

Journal of Virology, 2002-08, Vol.76 (15), p.7398-7406

2002

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Human immunodeficiency virus reverse transcriptase. Effect of primer length on template-primer binding

The Journal of biological chemistry, 1991-07, Vol.266 (21), p.14128-14134

1991

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Pharmacokinetics, oral bioavailability, and metabolic disposition in rats of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analog active against human immunodeficiency virus and hepatitis B virus

Antimicrobial Agents and Chemotherapy, 1993-11, Vol.37 (11), p.2285-2292

1993

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HIV-1 Protease: Characterization of a Catalytically Competent Enzyme−Substrate Intermediate

Biochemistry (Easton), 2002-01, Vol.41 (4), p.1302-1307

2002

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Discovery of potent pyrrolidone-based HIV-1 protease inhibitors with enhanced drug-like properties

Bioorganic & medicinal chemistry letters, 2004-11, Vol.14 (22), p.5689-5692

2004

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HIV protease assays

Current Protocols in Pharmacology, 2001-05, Vol.Chapter 3 (1), p.Unit3.2-Unit3.2

Furfine, E S

2001

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1400W Is a Slow, Tight Binding, and Highly Selective Inhibitor of Inducible Nitric-oxide Synthase in Vitro and in Vivo

Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas

Preclinical Pharmacology and Pharmacokinetics of GW433908, a Water-Soluble Prodrug of the Human Immunodeficiency Virus Protease Inhibitor Amprenavir

Metabolic complications associated with antiretroviral therapy

N-Phenylamidines as Selective Inhibitors of Human Neuronal Nitric Oxide Synthase: Structure−Activity Studies and Demonstration of in Vivo Activity

Potent and selective inhibition of human nitric oxide synthases. Selective inhibition of neuronal nitric oxide synthase by S-methyl-L-thiocitrulline and S-ethyl-L-thiocitrulline

HIV protease inhibitors block adipogenesis and increase lipolysis in vitro

Substituted N-Phenylisothioureas: Potent Inhibitors of Human Nitric Oxide Synthase with Neuronal Isoform Selectivity

Novel inhibitors of HIV protease : Design, synthesis and biological evaluation of picomolar inhibitors containing cyclic P1/P2 scaffolds

Reverse transcriptase.RNase H from the human immunodeficiency virus. Relationship of the DNA polymerase and RNA hydrolysis activities

Dietary Fat Alters HIV Protease Inhibitor–Induced Metabolic Changes in Mice

Biochemical studies on the reverse transcriptase and RNase H activities from human immunodeficiency virus strains resistant to 3'-azido-3'-deoxythymidine

Effectors of HIV-1 Protease Peptidolytic Activity

Substrate Binding Is Required for Release of Product from Mammalian Protein Farnesyltransferase

Human immunodeficiency virus. Mutations in the viral protease that confer resistance to saquinavir increase the dissociation rate constant of the protease-saquinavir complex

Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release

Analysis of resistance to human immunodeficiency virus type 1 protease inhibitors by using matched bacterial expression and proviral infection vectors

Stimulation of vitamin A(1) acid signaling by the HIV protease inhibitor indinavir

Inhibition of Wild-Type and Mutant Human Immunodeficiency Virus Type 1 Proteases by GW0385 and Other Arylsulfonamides

Changes in Human Immunodeficiency Virus Type 1 Gag at Positions L449 and P453 Are Linked to I50V Protease Mutants In Vivo and Cause Reduction of Sensitivity to Amprenavir and Improved Viral Fitness In Vitro

Human immunodeficiency virus reverse transcriptase. Effect of primer length on template-primer binding

Pharmacokinetics, oral bioavailability, and metabolic disposition in rats of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analog active against human immunodeficiency virus and hepatitis B virus

HIV-1 Protease: Characterization of a Catalytically Competent Enzyme−Substrate Intermediate

Discovery of potent pyrrolidone-based HIV-1 protease inhibitors with enhanced drug-like properties

HIV protease assays

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