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Nonclinical Studies that Support Viral Vector-Delivered Gene Therapies: An EFPIA Gene Therapy Working Group Perspective

Molecular therapy. Methods & clinical development, 2020-12, Vol.19, p.89-98

2020

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Activation of Triggering Receptor Expressed on Myeloid Cells-1 on Human Neutrophils by Marburg and Ebola Viruses

Journal of Virology, 2006-07, Vol.80 (14), p.7235-7244

2006

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NKp30-dependent cytolysis of filovirus-infected human dendritic cells

Cellular microbiology, 2007-04, Vol.9 (4), p.962-976

2007

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Current nonclinical approaches for immune assessments of immuno-oncology biotherapeutics

Drug discovery today, 2023-02, Vol.28 (2), p.103440, Article 103440

2023

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Challenges and gaps in immunosafety evaluation of therapeutics: An IQ DruSafe survey

Regulatory toxicology and pharmacology, 2024-06, Vol.150, p.105630-105630, Article 105630

2024

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All roads lead to actin: the intimate relationship between TCR signaling and the cytoskeleton

Immunological reviews, 2003-02, Vol.191 (1), p.220-236

2003

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A LAT Mutation That Inhibits T Cell Development Yet Induces Lymphoproliferation

Science (American Association for the Advancement of Science), 2002-06, Vol.296 (5575), p.2040-2043

2002

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Dendritic Cells Endocytose Bacillus anthracis Spores: Implications for Anthrax Pathogenesis

The Journal of immunology (1950), 2005-05, Vol.174 (9), p.5545-5552

2005

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Mutation of the phospholipase C-γ1–binding site of LAT affects both positive and negative thymocyte selection

The Journal of experimental medicine, 2005-04, Vol.201 (7), p.1125-1134

2005

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Transcriptome analysis of human immune responses following live vaccine strain (LVS) Francisella tularensis vaccination

Molecular immunology, 2007-05, Vol.44 (12), p.3173-3184

2007

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Dominance of human innate immune responses in primary Francisella tularensis live vaccine strain vaccination

Journal of allergy and clinical immunology, 2006-05, Vol.117 (5), p.1186-1188

2006

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Selective Induction of CD8+ Cytotoxic T Lymphocyte Effector Function by Staphylococcus Enterotoxin B

The Journal of immunology (1950), 1998-11, Vol.161 (10), p.5179-5186

1998

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Phosphatidylinositol 3-Kinase-Dependent and -Independent Cytolytic Effector Functions

The Journal of immunology (1950), 1999-06, Vol.162 (11), p.6337-6340

1999

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Suppressed clinical experimental autoimmune myasthenia gravis in bm12 mice is linked to reduced intracellular calcium mobilization and IL-10 and IFN-γ release by acetylcholine receptor-specific T cells

Journal of neuroimmunology, 2003, Vol.134 (1), p.104-110

2003

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Overview of nonclinical safety assessment

The Biomedical & Life Sciences Collection, 2020-09, Vol.2020 (9), p.e1005165

Fuller, Claudette L.

2020

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Mutation of the phospholipase C- gamma 1-binding site of LAT affects both positive and negative thymocyte selection

The Journal of experimental medicine, 2005-04, Vol.201 (7), p.1125-1134

2005

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Generation of IL-2-Dependent Cytolytic T Lymphocytes (CTLs) with Altered TCR Responses Derived from Antigen-Dependent CTL Clones

The Journal of immunology (1950), 1999-06, Vol.162 (11), p.6466-6472

1999

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High-resolution multicolor imaging of dynamic signaling complexes in T cells stimulated by planar substrates

Science's signal transduction knowledge environment (STKE), 2003-04, Vol.2003 (177), p.PL8

2003

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Ca2+ signaling modulates cytolytic T lymphocyte effector functions

The Journal of experimental medicine, 1998-04, Vol.187 (7), p.1057-1067

1998

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Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection

The Journal of experimental medicine, 2005-04, Vol.201 (7), p.1125-1134

2005

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Nonclinical Studies that Support Viral Vector-Delivered Gene Therapies: An EFPIA Gene Therapy Working Group Perspective

Activation of Triggering Receptor Expressed on Myeloid Cells-1 on Human Neutrophils by Marburg and Ebola Viruses

NKp30-dependent cytolysis of filovirus-infected human dendritic cells

Current nonclinical approaches for immune assessments of immuno-oncology biotherapeutics

Challenges and gaps in immunosafety evaluation of therapeutics: An IQ DruSafe survey

All roads lead to actin: the intimate relationship between TCR signaling and the cytoskeleton

A LAT Mutation That Inhibits T Cell Development Yet Induces Lymphoproliferation

Dendritic Cells Endocytose Bacillus anthracis Spores: Implications for Anthrax Pathogenesis

Mutation of the phospholipase C-γ1–binding site of LAT affects both positive and negative thymocyte selection

Transcriptome analysis of human immune responses following live vaccine strain (LVS) Francisella tularensis vaccination

Dominance of human innate immune responses in primary Francisella tularensis live vaccine strain vaccination

Selective Induction of CD8+ Cytotoxic T Lymphocyte Effector Function by Staphylococcus Enterotoxin B

Phosphatidylinositol 3-Kinase-Dependent and -Independent Cytolytic Effector Functions

Suppressed clinical experimental autoimmune myasthenia gravis in bm12 mice is linked to reduced intracellular calcium mobilization and IL-10 and IFN-γ release by acetylcholine receptor-specific T cells

Overview of nonclinical safety assessment

Mutation of the phospholipase C- gamma 1-binding site of LAT affects both positive and negative thymocyte selection

Generation of IL-2-Dependent Cytolytic T Lymphocytes (CTLs) with Altered TCR Responses Derived from Antigen-Dependent CTL Clones

High-resolution multicolor imaging of dynamic signaling complexes in T cells stimulated by planar substrates

Ca2+ signaling modulates cytolytic T lymphocyte effector functions

Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection

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