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Spirodiketopiperazine-Based CCR5 Inhibitor Which Preserves CC-Chemokine/CCR5 Interactions and Exerts Potent Activity against R5 Human Immunodeficiency Virus Type 1 In Vitro

Journal of Virology, 2004-08, Vol.78 (16), p.8654-8662

2004

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Novel Low Molecular Weight Spirodiketopiperazine Derivatives Potently Inhibit R5 HIV-1 Infection through Their Antagonistic Effects on CCR5

The Journal of biological chemistry, 2001-09, Vol.276 (37), p.35194-35200

2001

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Design, Synthesis, and Biological Evaluation of the Combinatorial Library with a New Spirodiketopiperazine Scaffold. Discovery of Novel Potent and Selective Low-Molecular-Weight CCR5 Antagonists

Journal of medicinal chemistry, 2006-07, Vol.49 (14), p.4140-4152

2006

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Degradation of decorin by matrix metalloproteinases: identification of the cleavage sites, kinetic analyses and transforming growth factor- β 1 release

Biochemical journal, 1997-03, Vol.322 (3), p.809-814

1997

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Discovery of orally available spirodiketopiperazine-based CCR5 antagonists

Bioorganic & medicinal chemistry, 2010-07, Vol.18 (14), p.5208-5223

2010

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Discovery of 4-[4-({(3 R)-1-butyl-3-[( R)-cyclohexyl(hydroxy)methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl}methyl)phenoxy]benzoic acid hydrochloride: A highly potent orally available CCR5 selective antagonist

Bioorganic & medicinal chemistry, 2011-07, Vol.19 (13), p.4028-4042

2011

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Spirodiketopiperazine-based CCR5 antagonists: Improvement of their pharmacokinetic profiles

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.763-766

2010

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Spirodiketopiperazine-based CCR5 antagonists: Lead optimization from biologically active metabolite

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (3), p.727-731

2007

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Spirodiketopiperazine-based CCR5 antagonist: Discovery of an antiretroviral drug candidate

Bioorganic & medicinal chemistry letters, 2011-02, Vol.21 (4), p.1141-1145

2011

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Discovery of 4-4-({(3R)-1-butyl-3-(R)-cyclohexyl(hydroxy)methyl-2,5-dioxo-1,4,9-triazaspiro5.5undec-9-yl}methyl)phenoxybenzoic acid hydrochloride: a highly potent orally available CCR5 selective antagonist

Bioorganic & medicinal chemistry, 2011-07, Vol.19 (13), p.4028

2011

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NEW SIMPLE SYNTHESES OF UNSYMMETRICAL DISULFIDES AND THIOLSULFONATES

Chemistry letters, 1977-08, Vol.6 (8), p.893-896

1977

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Localization of transforming growth factor beta binding site in betaglycan. Comparison with small extracellular matrix proteoglycans

The Journal of biological chemistry, 1993-10, Vol.268 (30), p.22710-22715

1993

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Functional micelles. 8. Micellar catalysis of the hydrolysis of substituted phenyl carboxylates by imidazole containing cationic surfactants

Journal of organic chemistry, 1979-02, Vol.44 (4), p.555-563

1979

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Nucleotide sequence of cloned cDNA for human pancreatic kallikrein

Biochemistry (Easton), 1985-12, Vol.24 (27), p.8037-8043

1985

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MULTISTEP OXIDATIONS OF THE UNSYMMETRICAL DISULFIDE AND THIOLSULFINATES: NEW EVIDENCE FOR THE FORMATION OF THE THIONITRITE AND THE SULFINYL DERIVATIVES AS THE INTERMEDIATES

Chemistry letters, 1978-03, Vol.7 (3), p.279-280

1978

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Enzymatic Oxidation of Disulfides and Thiolsulfinates by both Rabbit Liver Microsomes and a Reconstituted System with Purified Cytochrome P-450

Journal of biochemistry (Tokyo), 1978-04, Vol.83 (4), p.1019-1027

1978

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A 60-kD Protein Mediates the Binding of Transforming Growth Factor-β to Cell Surface and Extracellular Matrix Proteoglycans

The Journal of cell biology, 1993-08, Vol.122 (3), p.721-727

1993

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A 60-kD protein mediates the binding of transforming growth factor-(beta) to cell survace and extracellular matrix proteoglycans

The Journal of cell biology, 1993-08, Vol.122 (3), p.721

1993

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Structure Dependent Reactivity in the Oxygenation of Thiane Analogs by a Cytochrome P-450 Recon-stituted Enzyme System

Heterocycles, 1978, Vol.10 (1), p.229

1978

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Activation of the Secretory Pathway Leads to a Decrease in the Intracellular Amyloidogenic Fragments Generated from the Amyloid Protein Precursor

Biochemical and biophysical research communications, 1993-07, Vol.194 (1), p.202-207

1993

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MULTISTEP OXIDATIONS OF THE UNSYMMETRICAL DISULFIDE AND THIOLSULFINATES

Chemistry letters, 1978-03, Vol.7 (3), p.279

1978

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A synthetic amphiphilic helical docosapeptide with the surface properties of plasma apolipoprotein A-I

Journal of the American Chemical Society, 1979-06, Vol.101 (13), p.3703-3704

1979

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Binding of Amphiphilic Peptides to Phospholipid/Cholesterol Unilamellar Vesicles: A Model for Protein--Cholesterol Interaction

Proceedings of the National Academy of Sciences - PNAS, 1981-05, Vol.78 (5), p.2732-2736

1981

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New selective oxidation of thiols to the corresponding thiolsulfonates with dinitrogen tetroxide: one pot syntheses of thiolsulfonates from thiols

Tetrahedron letters, 1978, Vol.19 (14), p.1211-1212

1978

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Structural Analogs of Leukotrienes C and D avd Their Contractile Activities

Chemical and Pharmaceutical Bulletin, 1982/07/25, Vol.30(7), pp.2453-2462

1982

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Spirodiketopiperazine-Based CCR5 Inhibitor Which Preserves CC-Chemokine/CCR5 Interactions and Exerts Potent Activity against R5 Human Immunodeficiency Virus Type 1 In Vitro

Novel Low Molecular Weight Spirodiketopiperazine Derivatives Potently Inhibit R5 HIV-1 Infection through Their Antagonistic Effects on CCR5

Design, Synthesis, and Biological Evaluation of the Combinatorial Library with a New Spirodiketopiperazine Scaffold. Discovery of Novel Potent and Selective Low-Molecular-Weight CCR5 Antagonists

Degradation of decorin by matrix metalloproteinases: identification of the cleavage sites, kinetic analyses and transforming growth factor- β 1 release

Discovery of orally available spirodiketopiperazine-based CCR5 antagonists

Discovery of 4-[4-({(3 R)-1-butyl-3-[( R)-cyclohexyl(hydroxy)methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl}methyl)phenoxy]benzoic acid hydrochloride: A highly potent orally available CCR5 selective antagonist

Spirodiketopiperazine-based CCR5 antagonists: Improvement of their pharmacokinetic profiles

Spirodiketopiperazine-based CCR5 antagonists: Lead optimization from biologically active metabolite

Spirodiketopiperazine-based CCR5 antagonist: Discovery of an antiretroviral drug candidate

Discovery of 4-4-({(3R)-1-butyl-3-(R)-cyclohexyl(hydroxy)methyl-2,5-dioxo-1,4,9-triazaspiro5.5undec-9-yl}methyl)phenoxybenzoic acid hydrochloride: a highly potent orally available CCR5 selective antagonist

NEW SIMPLE SYNTHESES OF UNSYMMETRICAL DISULFIDES AND THIOLSULFONATES

Localization of transforming growth factor beta binding site in betaglycan. Comparison with small extracellular matrix proteoglycans

Functional micelles. 8. Micellar catalysis of the hydrolysis of substituted phenyl carboxylates by imidazole containing cationic surfactants

Nucleotide sequence of cloned cDNA for human pancreatic kallikrein

MULTISTEP OXIDATIONS OF THE UNSYMMETRICAL DISULFIDE AND THIOLSULFINATES: NEW EVIDENCE FOR THE FORMATION OF THE THIONITRITE AND THE SULFINYL DERIVATIVES AS THE INTERMEDIATES

Enzymatic Oxidation of Disulfides and Thiolsulfinates by both Rabbit Liver Microsomes and a Reconstituted System with Purified Cytochrome P-450

A 60-kD Protein Mediates the Binding of Transforming Growth Factor-β to Cell Surface and Extracellular Matrix Proteoglycans

A 60-kD protein mediates the binding of transforming growth factor-(beta) to cell survace and extracellular matrix proteoglycans

Structure Dependent Reactivity in the Oxygenation of Thiane Analogs by a Cytochrome P-450 Recon-stituted Enzyme System

Activation of the Secretory Pathway Leads to a Decrease in the Intracellular Amyloidogenic Fragments Generated from the Amyloid Protein Precursor

MULTISTEP OXIDATIONS OF THE UNSYMMETRICAL DISULFIDE AND THIOLSULFINATES

A synthetic amphiphilic helical docosapeptide with the surface properties of plasma apolipoprotein A-I

Binding of Amphiphilic Peptides to Phospholipid/Cholesterol Unilamellar Vesicles: A Model for Protein--Cholesterol Interaction

New selective oxidation of thiols to the corresponding thiolsulfonates with dinitrogen tetroxide: one pot syntheses of thiolsulfonates from thiols

Structural Analogs of Leukotrienes C and D avd Their Contractile Activities

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