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Novel cytokine release inhibitors. Part I: Triterpenes

Bioorganic & medicinal chemistry letters, 1998-07, Vol.8 (14), p.1883-1886

1998

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Novel Cyclic Compounds as Potent Phosphodiesterase 4 Inhibitors

Journal of medicinal chemistry, 1998-10, Vol.41 (22), p.4216-4223

1998

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Quaternary substituted PDE4 inhibitors I: The synthesis and in vitro evaluation of a novel series of oxindoles

Bioorganic & medicinal chemistry letters, 1998-01, Vol.8 (2), p.175-178

1998

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The synthesis and biological evaluation of a novel series of indole PDE4 inhibitors I

Bioorganic & medicinal chemistry letters, 1998-07, Vol.8 (14), p.1867-1872

1998

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Orally active indole N-oxide PDE4 inhibitors

Bioorganic & medicinal chemistry letters, 1998-11, Vol.8 (21), p.3053-3058

1998

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Quaternary substituted PDE IV inhibitors II: The synthesis and in vitro evaluation of a novel series of γ-lactams

Bioorganic & medicinal chemistry letters, 1998-02, Vol.8 (4), p.399-404

1998

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Novel cytokine release inhibitors. Part II: Steroids

Bioorganic & medicinal chemistry letters, 1998-10, Vol.8 (20), p.2825-2828

1998

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Novel cytokine release inhibitors. Part IV: Analogs of podocarpic acid

Bioorganic & medicinal chemistry letters, 1999-02, Vol.9 (3), p.469-474

1999

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Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in vivo effects on inflammation and anaphylaxis

Journal of medicinal chemistry, 1989-08, Vol.32 (8), p.1836-1842

1989

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Isolation and synthesis of pinoresinol diglucoside, a major antihypertensive principle of Tu-Chung (Eucommia ulmoides, Oliver)

Journal of the American Chemical Society, 1976-08, Vol.98 (17), p.5412-5413

1976

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Preparation of (R)- and (S)-mevalonic acids

Journal of the American Chemical Society, 1975-07, Vol.97 (14), p.4144-4145

1975

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A Novel Series of [2-[Methyl(2-phenethyl)amino]-2-oxoethyl]benzene-Containing Leukotriene B4 Antagonists: Initial Structure−Activity Relationships

Journal of medicinal chemistry, 1996-09, Vol.39 (19), p.3748-3755

1996

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Synthesis of 2-(2,3-dihydro-2-oxo-1,3,4-oxadiazol-5-yl) benzo heterocycles. A novel series of orally active antiallergic agents

Journal of medicinal chemistry, 1984-02, Vol.27 (2), p.121-125

1984

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Structure−Activity Relationships Study of Two Series of Leukotriene B4 Antagonists: Novel Indolyl and Naphthyl Compounds Substituted with a 2-[Methyl(2-phenethyl)amino]-2-oxoethyl Side Chain

Journal of medicinal chemistry, 1996-09, Vol.39 (19), p.3756-3768

1996

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Patent Update: Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis: Anti-inflammatory patent highlights part 2: Patents from the second half of 1993

Expert opinion on therapeutic patents, 1994-07, Vol.4 (7), p.785-802

1994

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Overview: Recent Developments in Sulphidopeptide Leukotriene Receptor Antagonists

Current Opinion on Therapeutic Patents, 1992-06, Vol.2 (6), p.811-833

1992

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Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene D4 receptor antagonists. 4. Addition of chromone moiety enhances leukotriene D4 receptor binding affinity

Journal of medicinal chemistry, 1991-05, Vol.34 (5), p.1704-1707

1991

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4-[2-[Methyl(2-phenethyl)amino]-2-oxoethyl]-8-(phenylmethoxy)-2-naphthalenecarboxylic acid: a high affinity, competitive, orally active leukotriene B4 receptor antagonist

Journal of medicinal chemistry, 1992-10, Vol.35 (22), p.4253-4255

1992

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ChemInform Abstract: Novel Cytokine Release Inhibitors. Part 3. Truncated Analogues of Tripterine

ChemInform, 1999-04, Vol.30 (17), p.no-no

1999

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1,2,4-Triazolo[4,3-a]quinoxaline-1,4-diones as antiallergic agents

Journal of medicinal chemistry, 1985-03, Vol.28 (3), p.363-366

1985

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Nonparticipation of .alpha.,.beta.-dehydrovalinyl intermediates in the formation of .delta.-(L-.alpha.-aminoadipyl)-L-cysteinyl-D-valine

Journal of the American Chemical Society, 1975-06, Vol.97 (13), p.3858-3859

1975

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Unusually facile bridgehead enolization. Locked boat forms in anti-Bredt olefins

Journal of the American Chemical Society, 1975-02, Vol.97 (4), p.904-905

1975

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The absolute configuration of the amino acids in δ-(α-aminoadipyl)cysteinylvaline from Penicillium chrysogenum

Biochemistry (Easton), 1976-01, Vol.15 (1), p.177-180

1976

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Novel cytokine release inhibitors. Part III: Truncated analogs of tripterine

Bioorganic & medicinal chemistry letters, 1998-12, Vol.8 (24), p.3659-3664

1998

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[1,4]Benzoxazine-2,3-diones as antiallergic agents

Journal of medicinal chemistry, 1985-01, Vol.28 (1), p.24-27

1985

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Novel cytokine release inhibitors. Part I: Triterpenes

Novel Cyclic Compounds as Potent Phosphodiesterase 4 Inhibitors

Quaternary substituted PDE4 inhibitors I: The synthesis and in vitro evaluation of a novel series of oxindoles

The synthesis and biological evaluation of a novel series of indole PDE4 inhibitors I

Orally active indole N-oxide PDE4 inhibitors

Quaternary substituted PDE IV inhibitors II: The synthesis and in vitro evaluation of a novel series of γ-lactams

Novel cytokine release inhibitors. Part II: Steroids

Novel cytokine release inhibitors. Part IV: Analogs of podocarpic acid

Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in vivo effects on inflammation and anaphylaxis

Isolation and synthesis of pinoresinol diglucoside, a major antihypertensive principle of Tu-Chung (Eucommia ulmoides, Oliver)

Preparation of (R)- and (S)-mevalonic acids

A Novel Series of [2-[Methyl(2-phenethyl)amino]-2-oxoethyl]benzene-Containing Leukotriene B4 Antagonists: Initial Structure−Activity Relationships

Synthesis of 2-(2,3-dihydro-2-oxo-1,3,4-oxadiazol-5-yl) benzo heterocycles. A novel series of orally active antiallergic agents

Structure−Activity Relationships Study of Two Series of Leukotriene B4 Antagonists: Novel Indolyl and Naphthyl Compounds Substituted with a 2-[Methyl(2-phenethyl)amino]-2-oxoethyl Side Chain

Patent Update: Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis: Anti-inflammatory patent highlights part 2: Patents from the second half of 1993

Overview: Recent Developments in Sulphidopeptide Leukotriene Receptor Antagonists

Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene D4 receptor antagonists. 4. Addition of chromone moiety enhances leukotriene D4 receptor binding affinity

4-[2-[Methyl(2-phenethyl)amino]-2-oxoethyl]-8-(phenylmethoxy)-2-naphthalenecarboxylic acid: a high affinity, competitive, orally active leukotriene B4 receptor antagonist

ChemInform Abstract: Novel Cytokine Release Inhibitors. Part 3. Truncated Analogues of Tripterine

1,2,4-Triazolo[4,3-a]quinoxaline-1,4-diones as antiallergic agents

Nonparticipation of .alpha.,.beta.-dehydrovalinyl intermediates in the formation of .delta.-(L-.alpha.-aminoadipyl)-L-cysteinyl-D-valine

Unusually facile bridgehead enolization. Locked boat forms in anti-Bredt olefins

The absolute configuration of the amino acids in δ-(α-aminoadipyl)cysteinylvaline from Penicillium chrysogenum

Novel cytokine release inhibitors. Part III: Truncated analogs of tripterine

[1,4]Benzoxazine-2,3-diones as antiallergic agents

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