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Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032)

Antimicrobial Agents and Chemotherapy, 2012-10, Vol.56 (10), p.5387-5396

2012

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p53 inhibition by the LANA protein of KSHV protects against cell death

Nature (London), 1999-12, Vol.402 (6764), p.889-894

1999

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Resistance Analysis of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir

Antimicrobial Agents and Chemotherapy, 2012-07, Vol.56 (7), p.3670-3681

2012

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The Discovery of Asunaprevir (BMS-650032), An Orally Efficacious NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

Journal of medicinal chemistry, 2014-03, Vol.57 (5), p.1730-1752

2014

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Combinations of Lambda Interferon with Direct-Acting Antiviral Agents Are Highly Efficient in Suppressing Hepatitis C Virus Replication

Antimicrobial Agents and Chemotherapy, 2013-03, Vol.57 (3), p.1312-1322

2013

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Impairment of type I but not type III IFN signaling by hepatitis C virus infection influences antiviral responses in primary human hepatocytes

PloS one, 2015-03, Vol.10 (3), p.e0121734-e0121734

2015

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Identification of I50L as the Signature Atazanavir (ATV)-Resistance Mutation in Treatment-Naive HIV-1-Infected Patients Receiving ATV-Containing Regimens

The Journal of infectious diseases, 2004-05, Vol.189 (10), p.1802-1810

2004

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Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor

ACS medicinal chemistry letters, 2018-02, Vol.9 (2), p.143-148

2018

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A Small Molecule Inhibitor Selectively Induces Apoptosis in Cells Transformed by High Risk Human Papilloma Viruses

PloS one, 2016-06, Vol.11 (6), p.e0155909-e0155909

2016

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Biochemical and Genetic Characterizations of a Novel Human Immunodeficiency Virus Type 1 Inhibitor That Blocks gp120-CD4 Interactions

Journal of Virology, 2003-10, Vol.77 (19), p.10528-10536

2003

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Modifications of the Human Immunodeficiency Virus Envelope Glycoprotein Enhance Immunogenicity for Genetic Immunization

Journal of Virology, 2002-06, Vol.76 (11), p.5357-5368

2002

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Molecular Basis for Increased Susceptibility of Isolates with Atazanavir Resistance-Conferring Substitution I50L to Other Protease Inhibitors

Antimicrobial Agents and Chemotherapy, 2005-09, Vol.49 (9), p.3825-3832

2005

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Development of a chimeric replicon system for phenotypic analysis of NS3 protease sequences from HCV clinical isolates

Antiviral therapy, 2011-01, Vol.16 (5), p.705-718

2011

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X-Ray Crystal Structures of Human Immunodeficiency Virus Type 1 Protease Mutants Complexed with Atazanavir

Journal of Virology, 2007-09, Vol.81 (17), p.9525-9535

2007

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Injection of human herpesvirus-8 in human skin engrafted on SCID mice induces Kaposi's sarcoma-like lesions

Journal of dermatological science, 2001-07, Vol.26 (3), p.182-193

2001

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IFN‐λ‐mediated IL‐12 production in macrophages induces IFN‐γ production in human NK cells

European journal of immunology, 2015-01, Vol.45 (1), p.250-259

2015

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Isolation and characterization of interferon lambda-resistant hepatitis C virus replicon cell lines

Virology (New York, N.Y.), 2013-09, Vol.444 (1), p.384-393

2013

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P3-P4 ureas and reverse carbamates as potent HCV NS3 protease inhibitors: Effective transposition of the P4 hydrogen bond donor

Bioorganic & medicinal chemistry letters, 2018-06, Vol.28 (10), p.1853-1859

2018

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IFN-[lambda]-mediated IL-12 production in macrophages induces IFN-[gamma] production in human NK cells

European journal of immunology, 2015-01, Vol.45 (1), p.250

2015

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The discovery and optimization of naphthalene-linked P2-P4 Macrocycles as inhibitors of HCV NS3 protease

Bioorganic & medicinal chemistry letters, 2018-01, Vol.28 (1), p.43-48

2018

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In Vitro Assessment of Re-treatment Options for Patients with Hepatitis C Virus Genotype 1b Infection Resistant to Daclatasvir Plus Asunaprevir

Infectious diseases and therapy, 2015-03, Vol.4 (1), p.137-144

2015

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Distinct Biology of Kaposi’s Sarcoma-Associated Herpesvirus from Primary Lesions and Body Cavity Lymphomas

Journal of Virology, 1998-12, Vol.72 (12), p.10073-10082

1998

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Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing

Journal of medicinal chemistry, 2016-09, Vol.59 (17), p.8042-8060

2016

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Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides: A series of potent NS3 protease inhibitors for the treatment of hepatitis C virus

Bioorganic & medicinal chemistry letters, 2017-02, Vol.27 (3), p.590-596

2017

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Endogenous IFNλ in viral hepatitis patients

Journal of interferon & cytokine research, 2014-07, Vol.34 (7), p.552-556

2014

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Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032)

p53 inhibition by the LANA protein of KSHV protects against cell death

Resistance Analysis of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir

The Discovery of Asunaprevir (BMS-650032), An Orally Efficacious NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

Combinations of Lambda Interferon with Direct-Acting Antiviral Agents Are Highly Efficient in Suppressing Hepatitis C Virus Replication

Impairment of type I but not type III IFN signaling by hepatitis C virus infection influences antiviral responses in primary human hepatocytes

Identification of I50L as the Signature Atazanavir (ATV)-Resistance Mutation in Treatment-Naive HIV-1-Infected Patients Receiving ATV-Containing Regimens

Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor

A Small Molecule Inhibitor Selectively Induces Apoptosis in Cells Transformed by High Risk Human Papilloma Viruses

Biochemical and Genetic Characterizations of a Novel Human Immunodeficiency Virus Type 1 Inhibitor That Blocks gp120-CD4 Interactions

Modifications of the Human Immunodeficiency Virus Envelope Glycoprotein Enhance Immunogenicity for Genetic Immunization

Molecular Basis for Increased Susceptibility of Isolates with Atazanavir Resistance-Conferring Substitution I50L to Other Protease Inhibitors

Development of a chimeric replicon system for phenotypic analysis of NS3 protease sequences from HCV clinical isolates

X-Ray Crystal Structures of Human Immunodeficiency Virus Type 1 Protease Mutants Complexed with Atazanavir

Injection of human herpesvirus-8 in human skin engrafted on SCID mice induces Kaposi's sarcoma-like lesions

IFN‐λ‐mediated IL‐12 production in macrophages induces IFN‐γ production in human NK cells

Isolation and characterization of interferon lambda-resistant hepatitis C virus replicon cell lines

P3-P4 ureas and reverse carbamates as potent HCV NS3 protease inhibitors: Effective transposition of the P4 hydrogen bond donor

IFN-[lambda]-mediated IL-12 production in macrophages induces IFN-[gamma] production in human NK cells

The discovery and optimization of naphthalene-linked P2-P4 Macrocycles as inhibitors of HCV NS3 protease

In Vitro Assessment of Re-treatment Options for Patients with Hepatitis C Virus Genotype 1b Infection Resistant to Daclatasvir Plus Asunaprevir

Distinct Biology of Kaposi’s Sarcoma-Associated Herpesvirus from Primary Lesions and Body Cavity Lymphomas

Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing

Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides: A series of potent NS3 protease inhibitors for the treatment of hepatitis C virus

Endogenous IFNλ in viral hepatitis patients

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