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Differential stereospecificities and affinities of folate receptor isoforms for folate compounds and antifolates

Biochemical pharmacology, 1992-11, Vol.44 (9), p.1898-1901

1992

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Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate

Biochemistry (Easton), 1990-10, Vol.29 (40), p.9467-9479

1990

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Kinetics of the formation and isomerization of methotrexate complexes of recombinant human dihydrofolate reductase

The Journal of biological chemistry, 1988-07, Vol.263 (21), p.10304-10313

1988

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2,4-Diaminothieno[2,3-d]pyrimidine analogs of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase

Journal of medicinal chemistry, 1993-10, Vol.36 (21), p.3103-3112

1993

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Unusual transient- and steady-state kinetic behavior is predicted by the kinetic scheme operational for recombinant human dihydrofolate reductase

The Journal of biological chemistry, 1990-02, Vol.265 (5), p.2740-2748

1990

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Hydride transfer by dihydrofolate reductase. Causes and consequences of the wide range of rates exhibited by bacterial and vertebrate enzymes

The Journal of biological chemistry, 1989-06, Vol.264 (16), p.9391-9399

1989

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Expression and site-directed mutagenesis of human dihydrofolate reductase

Biochemistry (Easton), 1988-05, Vol.27 (10), p.3664-3671

1988

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Characterization of Candida albicans Dihydrofolate Reductase

The Journal of biological chemistry, 1989-01, Vol.264 (2), p.1100-1107

1989

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Site-directed deletion mutants of a carboxyl-terminal region of human dihydrofolate reductase

The Journal of biological chemistry, 1992-01, Vol.267 (2), p.864-870

1992

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Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA

Biochemistry (Easton), 1989-10, Vol.28 (20), p.8249-8254

1989

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Conversion of arginine to lysine at position 70 of human dihydrofolate reductase: generation of a methotrexate-insensitive mutant enzyme

Biochemistry (Easton), 1991-08, Vol.30 (33), p.8124-8130

1991

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Atypical transient state kinetics of recombinant human dihydrofolate reductase produced by hysteretic behavior. Comparison with dihydrofolate reductases from other sources

The Journal of biological chemistry, 1989-02, Vol.264 (5), p.2625-2633

1989

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Mapping the antigenic epitopes of human dihydrofolate reductase by systematic synthesis of peptides on solid supports

The Journal of biological chemistry, 1990-05, Vol.265 (14), p.8022-8026

1990

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The importance of loop region residues 40-46 in human dihydrofolate reductase as revealed by site-directed mutagenesis

The Journal of biological chemistry, 1990-05, Vol.265 (14), p.8027-8032

1990

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Role of the conserved active site residue tryptophan-24 of human dihydrofolate reductase as revealed by mutagenesis

Biochemistry (Easton), 1991-02, Vol.30 (5), p.1432-1440

1991

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Characterization of the methotrexate transport pathway in murine L1210 leukemia cells: involvement of a membrane receptor and a cytosolic protein

Biochemistry (Easton), 1988-10, Vol.27 (20), p.7853-7858

1988

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Crystal structure determination at 2.3 A of recombinant human dihydrofolate reductase ternary complex with NADPH and methotrexate-gamma-tetrazole

Anti-cancer drug design, 1992-12, Vol.7 (6), p.483

1992

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Synthesis and biological evaluation of a fluorescent analog of folic acid

Biochemistry (Easton), 1991-06, Vol.30 (23), p.5674-5681

1991

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Kinetic investigation of the functional role of phenylalanine-31 of recombinant human dihydrofolate reductase

Biochemistry (Easton), 1990-07, Vol.29 (27), p.6428-6436

1990

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Role of lysine-54 in determining cofactor specificity and binding in human dihydrofolate reductase

Biochemistry (Easton), 1990-09, Vol.29 (35), p.8063-8069

1990

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Regiospecific gamma-conjugation of methotrexate to poly(L-lysine). Chemical and biological studies

Molecular pharmacology, 1985-01, Vol.27 (1), p.141-147

1985

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Effects of conversion of phenylalanine-31 to leucine on the function of human dihydrofolate reductase

Biochemistry (Easton), 1989-05, Vol.28 (11), p.4645-4650

1989

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Inhibition of mammalian folylpolyglutamate synthetase and human dihydrofolate reductase by 5,8-dideaza analogs of folic acid and aminopterin bearing a terminal L-ornithine

Journal of medicinal chemistry, 1989-07, Vol.32 (7), p.1559-1565

1989

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Studies on the mechanism of antitumor action of 2-desamino-2-methyl-5,8-dideazaisofolic acid

Biochemical pharmacology, 1991-03, Vol.41 (5), p.781-787

1991

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Chemistry and antitumor evaluation of selected classical 2,4-diaminoquinazoline analogs of folic acid

Journal of medicinal chemistry, 1985-02, Vol.28 (2), p.209-215

1985

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Differential stereospecificities and affinities of folate receptor isoforms for folate compounds and antifolates

Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate

Kinetics of the formation and isomerization of methotrexate complexes of recombinant human dihydrofolate reductase

2,4-Diaminothieno[2,3-d]pyrimidine analogs of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase

Unusual transient- and steady-state kinetic behavior is predicted by the kinetic scheme operational for recombinant human dihydrofolate reductase

Hydride transfer by dihydrofolate reductase. Causes and consequences of the wide range of rates exhibited by bacterial and vertebrate enzymes

Expression and site-directed mutagenesis of human dihydrofolate reductase

Characterization of Candida albicans Dihydrofolate Reductase

Site-directed deletion mutants of a carboxyl-terminal region of human dihydrofolate reductase

Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA

Conversion of arginine to lysine at position 70 of human dihydrofolate reductase: generation of a methotrexate-insensitive mutant enzyme

Atypical transient state kinetics of recombinant human dihydrofolate reductase produced by hysteretic behavior. Comparison with dihydrofolate reductases from other sources

Mapping the antigenic epitopes of human dihydrofolate reductase by systematic synthesis of peptides on solid supports

The importance of loop region residues 40-46 in human dihydrofolate reductase as revealed by site-directed mutagenesis

Role of the conserved active site residue tryptophan-24 of human dihydrofolate reductase as revealed by mutagenesis

Characterization of the methotrexate transport pathway in murine L1210 leukemia cells: involvement of a membrane receptor and a cytosolic protein

Crystal structure determination at 2.3 A of recombinant human dihydrofolate reductase ternary complex with NADPH and methotrexate-gamma-tetrazole

Synthesis and biological evaluation of a fluorescent analog of folic acid

Kinetic investigation of the functional role of phenylalanine-31 of recombinant human dihydrofolate reductase

Role of lysine-54 in determining cofactor specificity and binding in human dihydrofolate reductase

Regiospecific gamma-conjugation of methotrexate to poly(L-lysine). Chemical and biological studies

Effects of conversion of phenylalanine-31 to leucine on the function of human dihydrofolate reductase

Inhibition of mammalian folylpolyglutamate synthetase and human dihydrofolate reductase by 5,8-dideaza analogs of folic acid and aminopterin bearing a terminal L-ornithine

Studies on the mechanism of antitumor action of 2-desamino-2-methyl-5,8-dideazaisofolic acid

Chemistry and antitumor evaluation of selected classical 2,4-diaminoquinazoline analogs of folic acid

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