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Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

Antimicrobial Agents and Chemotherapy, 2013-07, Vol.57 (7), p.2913-2922

2013

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Finding new hits in neglected disease projects: target or phenotypic based screening?

Current topics in medicinal chemistry, 2011-05, Vol.11 (10), p.1284

2011

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IspE inhibitors identified by a combination of in silico and in vitro high-throughput screening

PloS one, 2012-04, Vol.7 (4), p.e35792-e35792

2012

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One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

Journal of medicinal chemistry, 2009-07, Vol.52 (14), p.4454-4465

2009

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Screening a protein kinase inhibitor library against Plasmodium falciparum

Malaria journal, 2017-11, Vol.16 (1), p.446-446, Article 446

2017

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High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules

Biochemical journal, 2010-11, Vol.432 (1), p.21-35

2010

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Acetazolamide-based fungal chitinase inhibitors

Bioorganic & medicinal chemistry, 2010-12, Vol.18 (23), p.8334-8340

2010

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Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei

ChemMedChem, 2009-12, Vol.4 (12), p.2060-2069

2009

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Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase

ChemMedChem, 2009-08, Vol.4 (8), p.1341-1353

2009

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A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N‑Myristoyltransferase Inhibitors

Journal of medicinal chemistry, 2018-09, Vol.61 (18), p.8374-8389

2018

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The Design and Synthesis of Potent and Selective Inhibitors of Trypanosoma brucei Glycogen Synthase Kinase 3 for the Treatment of Human African Trypanosomiasis

Journal of medicinal chemistry, 2014-09, Vol.57 (18), p.7536-7549

2014

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HTS and hit finding in academia – from chemical genomics to drug discovery

Drug discovery today, 2009-12, Vol.14 (23-24), p.1150-1158

2009

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Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography

Journal of medicinal chemistry, 2011-10, Vol.54 (19), p.6514-6530

2011

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Design and Synthesis of Brain Penetrant Trypanocidal N‑Myristoyltransferase Inhibitors

Journal of medicinal chemistry, 2017-12, Vol.60 (23), p.9790-9806

2017

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Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static–Cidal Screening of Analogues

Journal of medicinal chemistry, 2023-07, Vol.66 (13), p.8896-8916

2023

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Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

Biochemical pharmacology, 2010-11, Vol.80 (10), p.1478-1486

2010

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Target assessment for antiparasitic drug discovery

Trends in parasitology, 2007-12, Vol.23 (12), p.589-595

2007

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Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

Journal of medicinal chemistry, 2012-01, Vol.55 (1), p.140-152

2012

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The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines

Cell chemical biology, 2017-08, Vol.24 (8), p.981-992.e4

2017

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Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei

Journal of medicinal chemistry, 2015-10, Vol.58 (19), p.7695-7706

2015

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Chemical Validation of Trypanothione Synthetase: A POTENTIAL DRUG TARGET FOR HUMAN TRYPANOSOMIASIS

The Journal of biological chemistry, 2009-12, Vol.284 (52), p.36137-36145

2009

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Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode

ChemMedChem, 2015-11, Vol.10 (11), p.1821-1836

2015

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Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

Finding new hits in neglected disease projects: target or phenotypic based screening?

Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma brucei N‑Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis

IspE inhibitors identified by a combination of in silico and in vitro high-throughput screening

One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

Screening a protein kinase inhibitor library against Plasmodium falciparum

High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules

Acetazolamide-based fungal chitinase inhibitors

Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei

Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N‑Myristoyltransferase Inhibitors

The Design and Synthesis of Potent and Selective Inhibitors of Trypanosoma brucei Glycogen Synthase Kinase 3 for the Treatment of Human African Trypanosomiasis

HTS and hit finding in academia – from chemical genomics to drug discovery

Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

Design and Synthesis of Brain Penetrant Trypanocidal N‑Myristoyltransferase Inhibitors

Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static–Cidal Screening of Analogues

N -myristoyltransferase inhibitors as new leads to treat sleeping sickness

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

Target assessment for antiparasitic drug discovery

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines

Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei

Chemical Validation of Trypanothione Synthetase: A POTENTIAL DRUG TARGET FOR HUMAN TRYPANOSOMIASIS

Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode

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