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Cisplatin resistance in non-small cell lung cancer cells is associated with an abrogation of cisplatin-induced G2/M cell cycle arrest

PloS one, 2017-07, Vol.12 (7), p.e0181081-e0181081

2017

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Development and validation of a high-throughput transcriptomic biomarker to address 21st century genetic toxicology needs

Proceedings of the National Academy of Sciences - PNAS, 2017-12, Vol.114 (51), p.E10881-E10889

2017

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Key Players of Cisplatin Resistance: Towards a Systems Pharmacology Approach

International journal of molecular sciences, 2018-03, Vol.19 (3), p.767

2018

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The EU Response to the Presence of Nitrosamine Impurities in Medicines

Frontiers in medicine, 2021-11, Vol.8, p.782536-782536

2021

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Inhibition of the PI3K but not the MEK/ERK pathway sensitizes human glioma cells to alkylating drugs

Cancer cell international, 2018-05, Vol.18 (1), p.69-69, Article 69

2018

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Integrated Genotoxicity Testing of three anti-infective drugs using the TGx-DDI transcriptomic biomarker and high-throughput CometChip ® assay in TK6 cells

Frontiers in toxicology, 2022-09, Vol.4, p.991590

2022

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IWGT report on quantitative approaches to genotoxicity risk assessment I. Methods and metrics for defining exposure–response relationships and points of departure (PoDs)

Mutation research. Genetic toxicology and environmental mutagenesis, 2015-05, Vol.783, p.55-65

2015

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N-Nitrosodimethylamine-Contaminated Valsartan and the Risk of Cancer

Deutsches Ärzteblatt international, 2021-05

2021

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Experiences with the in vivo and in vitro comet assay in regulatory testing

Mutagenesis, 2015-01, Vol.30 (1), p.51-57

Frotschl, R.

2015

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Is sunitinib a Narrow Therapeutic Index Drug? – A systematic review and in vitro toxicology-analysis of Sunitinib vs. Imatinib in cells from different tissues

Regulatory toxicology and pharmacology, 2016-06, Vol.77, p.25-34

2016

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In vitro genotoxicity test approaches with better predictivity: Summary of an IWGT workshop

Mutation research, 2011-08, Vol.723 (2), p.101-107

2011

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In vivo alkaline comet assay: Statistical considerations on historical negative and positive control data

Regulatory toxicology and pharmacology, 2024-03, Vol.148, p.105583-105583, Article 105583

2024

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Next Generation Sequencing Workshop at the Royal Society of Medicine (London, May 2022): how genomics is on the path to modernizing genetic toxicology

Mutagenesis, 2023-08, Vol.38 (4), p.192-200

2023

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N-Nitrosodimethylamine-Contaminated Valsartan and the Risk of Cancer—A Longitudinal Cohort Study Based on German Health Insurance Data

Deutsches Ärzteblatt international, 2021-05, Vol.118 (21), p.357-362

2021

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TGx-DDI, a Transcriptomic Biomarker for Genotoxicity Hazard Assessment of Pharmaceuticals and Environmental Chemicals

Frontiers in big data, 2019-10, Vol.2, p.36

2019

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The rat bone marrow micronucleus test: Statistical considerations on historical negative control data

Regulatory toxicology and pharmacology, 2019-03, Vol.102, p.13-22

2019

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Cisplatin resistance in non-small cell lung cancer cells is associated with an abrogation of cisplatin-induced G.sub.2/M cell cycle arrest

PloS one, 2017-07, Vol.12 (7), p.e0181081

2017

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IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-of-departure (PoD) metrics in defining acceptable exposure limits and assessing human risk

Mutation research. Genetic toxicology and environmental mutagenesis, 2015-05, Vol.783, p.66-78

2015

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Time-matched analysis of DNA adduct formation and early gene expression as predictive tool for renal carcinogenesis in methylazoxymethanol acetate treated Eker rats

Archives of toxicology, 2017-10, Vol.91 (10), p.3427-3438

2017

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N-Nitrosodimethylamine-Contaminated Valsartan and the Risk of Cancer—A Longitudinal Cohort Study Based on German Health Insurance Data

Deutsches Ärzteblatt international, 2021-05, Vol.118 (Forthcoming)

2021

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Knowledge-based approach to identify key determinants of cisplatin sensitivity

International journal of clinical pharmacology and therapeutics, 2017-08, Vol.55 (8), p.686-689

2017

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Polymorphisms of drug-metabolizing enzymes CYP2C9, CYP2C19, CYP2D6, CYP1A1, NAT2 and of P-glycoprotein in a Russian population

European journal of clinical pharmacology, 2003-08, Vol.59 (4), p.303-312

2003

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NSCLC cells adapted to EGFR inhibition accumulate EGFR interacting proteins and down-regulate microRNA related to epithelial-mesenchymal transition

International journal of clinical pharmacology and therapeutics, 2014-01, Vol.52 (1), p.92-94

2014

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A systems pharmacology approach to improve drug therapy in NSCLC: establishing a CESAR network

International journal of clinical pharmacology and therapeutics, 2014-01, Vol.52 (1), p.89-91

2014

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Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells

Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 2005-08, Vol.575 (1), p.47-60

2005

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Cisplatin resistance in non-small cell lung cancer cells is associated with an abrogation of cisplatin-induced G2/M cell cycle arrest

Development and validation of a high-throughput transcriptomic biomarker to address 21st century genetic toxicology needs

Key Players of Cisplatin Resistance: Towards a Systems Pharmacology Approach

The EU Response to the Presence of Nitrosamine Impurities in Medicines

Inhibition of the PI3K but not the MEK/ERK pathway sensitizes human glioma cells to alkylating drugs

Integrated Genotoxicity Testing of three anti-infective drugs using the TGx-DDI transcriptomic biomarker and high-throughput CometChip ® assay in TK6 cells

IWGT report on quantitative approaches to genotoxicity risk assessment I. Methods and metrics for defining exposure–response relationships and points of departure (PoDs)

N-Nitrosodimethylamine-Contaminated Valsartan and the Risk of Cancer

Experiences with the in vivo and in vitro comet assay in regulatory testing

Is sunitinib a Narrow Therapeutic Index Drug? – A systematic review and in vitro toxicology-analysis of Sunitinib vs. Imatinib in cells from different tissues

In vitro genotoxicity test approaches with better predictivity: Summary of an IWGT workshop

In vivo alkaline comet assay: Statistical considerations on historical negative and positive control data

Next Generation Sequencing Workshop at the Royal Society of Medicine (London, May 2022): how genomics is on the path to modernizing genetic toxicology

N-Nitrosodimethylamine-Contaminated Valsartan and the Risk of Cancer—A Longitudinal Cohort Study Based on German Health Insurance Data

TGx-DDI, a Transcriptomic Biomarker for Genotoxicity Hazard Assessment of Pharmaceuticals and Environmental Chemicals

The rat bone marrow micronucleus test: Statistical considerations on historical negative control data

Cisplatin resistance in non-small cell lung cancer cells is associated with an abrogation of cisplatin-induced G.sub.2/M cell cycle arrest

IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-of-departure (PoD) metrics in defining acceptable exposure limits and assessing human risk

Time-matched analysis of DNA adduct formation and early gene expression as predictive tool for renal carcinogenesis in methylazoxymethanol acetate treated Eker rats

N-Nitrosodimethylamine-Contaminated Valsartan and the Risk of Cancer—A Longitudinal Cohort Study Based on German Health Insurance Data

Knowledge-based approach to identify key determinants of cisplatin sensitivity

Polymorphisms of drug-metabolizing enzymes CYP2C9, CYP2C19, CYP2D6, CYP1A1, NAT2 and of P-glycoprotein in a Russian population

NSCLC cells adapted to EGFR inhibition accumulate EGFR interacting proteins and down-regulate microRNA related to epithelial-mesenchymal transition

A systems pharmacology approach to improve drug therapy in NSCLC: establishing a CESAR network

Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells

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