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AMPK as a Therapeutic Target for Treating Metabolic Diseases

Trends in endocrinology and metabolism, 2017-08, Vol.28 (8), p.545-560

2017

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Treatment of nonalcoholic fatty liver disease: role of AMPK

American journal of physiology: endocrinology and metabolism, 2016-10, Vol.311 (4), p.E730-E740

2016

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The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels

Diabetes (New York, N.Y.), 2016-09, Vol.65 (9), p.2784-2794

2016

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AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging

Cell metabolism, 2015-06, Vol.21 (6), p.883-890

2015

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Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis

Nature communications, 2016-11, Vol.7 (1), p.13457-13457, Article 13457

2016

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Growth Differentiation Factor 15 as a Novel Biomarker for Metformin

Diabetes care, 2017-02, Vol.40 (2), p.280-283

2017

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Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

Nature medicine, 2013-12, Vol.19 (12), p.1649-1654

2013

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Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis

Nature medicine, 2015-02, Vol.21 (2), p.166-172

2015

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Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity

Biochemical journal, 2015-05, Vol.468 (1), p.125-132

2015

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Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss

Nature metabolism, 2019-12, Vol.1 (12), p.1202-1208

2019

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Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate

Cellular signalling, 2015-05, Vol.27 (5), p.978-988

2015

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The diabetes medication Canagliflozin reduces cancer cell proliferation by inhibiting mitochondrial complex-I supported respiration

Molecular metabolism (Germany), 2016-10, Vol.5 (10), p.1048-1056

2016

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The SGLT2 inhibitor canagliflozin suppresses lipid synthesis and interleukin-1 beta in ApoE deficient mice

Biochemical journal, 2020-06, Vol.477 (12), p.2347-2361

2020

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The AMPK agonist 5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation‐associated cachectic muscle wasting

EMBO molecular medicine, 2018-07, Vol.10 (7), p.1-n/a

2018

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Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662

American journal of physiology: endocrinology and metabolism, 2014-03, Vol.306 (6), p.E688-E696

2014

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Salicylate improves macrophage cholesterol homeostasis via activation of Ampk

Journal of lipid research, 2015-05, Vol.56 (5), p.1025-1033

2015

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PPARδ activation attenuates hepatic steatosis in Ldlr−/− mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity

Journal of lipid research, 2014-07, Vol.55 (7), p.1254-1266

2014

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Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants

Molecular metabolism (Germany), 2017-11, Vol.6 (11), p.1503-1516

2017

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AMP-activated protein kinase activator AICAR acutely lowers blood pressure and relaxes isolated resistance arteries of hypertensive rats

Journal of hypertension, 2012-04, Vol.30 (4), p.725-733

2012

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Salsalate reduces atherosclerosis through AMPKβ1 in mice

Molecular metabolism (Germany), 2021-11, Vol.53, p.101321-101321, Article 101321

2021

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Chronic in vivo or acute in vitro resveratrol attenuates endothelium-dependent cyclooxygenase-mediated contractile signaling in hypertensive rat carotid artery

Journal of applied physiology (1985), 2016-05, Vol.120 (10), p.1141-1150

2016

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Loss of TDAG51 Results in Mature-Onset Obesity, Hepatic Steatosis, and Insulin Resistance by Regulating Lipogenesis

Diabetes (New York, N.Y.), 2013-01, Vol.62 (1), p.158-169

2013

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Author Correction: Metformin-induced ablation of microRNA 21-5p releases Sestrin-1 and CAB39L antitumoral activities

Cell discovery, 2024-03, Vol.10 (1), p.29-29, Article 29

2024

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Are SIRT1 activators another indirect method to increase AMPK for beneficial effects on aging and the metabolic syndrome?

EBioMedicine, 2017-05, Vol.19 (C), p.16-17

2017

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AMPK as a Therapeutic Target for Treating Metabolic Diseases

Treatment of nonalcoholic fatty liver disease: role of AMPK

The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels

AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging

Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis

Growth Differentiation Factor 15 as a Novel Biomarker for Metformin

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis

Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity

Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss

Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate

The diabetes medication Canagliflozin reduces cancer cell proliferation by inhibiting mitochondrial complex-I supported respiration

The SGLT2 inhibitor canagliflozin suppresses lipid synthesis and interleukin-1 beta in ApoE deficient mice

The AMPK agonist 5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation‐associated cachectic muscle wasting

Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662

Salicylate improves macrophage cholesterol homeostasis via activation of Ampk

PPARδ activation attenuates hepatic steatosis in Ldlr−/− mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity

Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants

AMP-activated protein kinase activator AICAR acutely lowers blood pressure and relaxes isolated resistance arteries of hypertensive rats

Salsalate reduces atherosclerosis through AMPKβ1 in mice

Chronic in vivo or acute in vitro resveratrol attenuates endothelium-dependent cyclooxygenase-mediated contractile signaling in hypertensive rat carotid artery

Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma

Loss of TDAG51 Results in Mature-Onset Obesity, Hepatic Steatosis, and Insulin Resistance by Regulating Lipogenesis

Author Correction: Metformin-induced ablation of microRNA 21-5p releases Sestrin-1 and CAB39L antitumoral activities

Are SIRT1 activators another indirect method to increase AMPK for beneficial effects on aging and the metabolic syndrome?

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