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Oxazolidinone Structure-Activity Relationships Leading to Linezolid

Angewandte Chemie (International ed.), 2003-05, Vol.42 (18), p.2010-2023

2003

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Discovery and Characterization of QPT-1, the Progenitor of a New Class of Bacterial Topoisomerase Inhibitors

Antimicrobial Agents and Chemotherapy, 2008-08, Vol.52 (8), p.2806-2812

2008

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Synthesis and Antibacterial Activity of U-100592 and U-100766, Two Oxazolidinone Antibacterial Agents for the Potential Treatment of Multidrug-Resistant Gram-Positive Bacterial Infections

Journal of medicinal chemistry, 1996-02, Vol.39 (3), p.673-679

1996

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Efficacy of Linezolid in Treatment of Experimental Endocarditis Caused by Methicillin-Resistant Staphylococcus aureus

Antimicrobial Agents and Chemotherapy, 2001-08, Vol.45 (8), p.2304-2308

2001

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Piperazinyl Oxazolidinone Antibacterial Agents Containing a Pyridine, Diazene, or Triazene Heteroaromatic Ring

Journal of medicinal chemistry, 1998-09, Vol.41 (19), p.3727-3735

1998

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Identification of Staphylococcus aureus virulence genes in a murine model of bacteraemia using signature‐tagged mutagenesis

Molecular microbiology, 1997-10, Vol.26 (2), p.399-407

1997

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Virulence factor expression by Gram-positive cocci exposed to subinhibitory concentrations of linezolid

Journal of antimicrobial chemotherapy, 2002-11, Vol.50 (5), p.665-672

2002

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MICs of Oxazolidinones for Rhodococcus equi Strains Isolated from Humans and Animals

Antimicrobial Agents and Chemotherapy, 2000-05, Vol.44 (5), p.1367-1369

2000

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Identification of Phenylisoxazolines as Novel and Viable Antibacterial Agents Active against Gram-Positive Pathogens

Journal of medicinal chemistry, 2003-01, Vol.46 (2), p.284-302

2003

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The synthesis and antibacterial activity of 1,3,4-Thiadiazole phenyl oxazolidinone analogues

Bioorganic & medicinal chemistry letters, 2003-12, Vol.13 (23), p.4193-4196

2003

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Oxazolidinones: a new class of antibacterials

Current Opinion in Pharmacology, 2001-10, Vol.1 (5), p.470-476

2001

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Identification of a Novel Oxazolidinone (U-100480) with Potent Antimycobacterial Activity

Journal of medicinal chemistry, 1996-02, Vol.39 (3), p.680-685

1996

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New Antibacterial tetrahydro-4(2 H)-thiopyran and thiomorpholine S-oxide and S, S-dioxide phenyloxazolidinones

Bioorganic & medicinal chemistry letters, 2003-12, Vol.13 (23), p.4209-4212

2003

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Synthesis and biological evaluation of benzazepine oxazolidinone antibacterials

Bioorganic & medicinal chemistry letters, 2003-12, Vol.13 (23), p.4197-4200

2003

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Efficacy of linezolid in a staphylococcal endocarditis rabbit model

Journal of antimicrobial chemotherapy, 2001-03, Vol.47 (3), p.349-352

2001

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The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones

Bioorganic & medicinal chemistry letters, 2003-12, Vol.13 (23), p.4235-4239

2003

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Carbon–carbon-linked (pyrazolylphenyl)oxazolidinones with antibacterial activity against multiple drug resistant gram-positive and fastidious gram-negative bacteria

Bioorganic & medicinal chemistry, 2001-12, Vol.9 (12), p.3243-3253

2001

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Substituent Effects on the Antibacterial Activity of Nitrogen−Carbon-Linked (Azolylphenyl)oxazolidinones with Expanded Activity Against the Fastidious Gram-Negative Organisms Haemophilus influenzae and Moraxella catarrhalis

Journal of medicinal chemistry, 2000-03, Vol.43 (5), p.953-970

2000

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Influence of Perceived Control over Time on College Students' Stress and Stress-Related Outcomes

Research in higher education, 1998-10, Vol.39 (5), p.587-605

1998

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Nitrogen−Carbon-Linked (Azolylphenyl)oxazolidinones with Potent Antibacterial Activity Against the Fastidious Gram-Negative Organisms Haemophilus influenzae and Moraxella catarrhalis

Journal of medicinal chemistry, 1998-12, Vol.41 (26), p.5144-5147

1998

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Substituent Effects on the Antibacterial Activity of Nitrogen−Carbon-Linked (Azolylphenyl)oxazolidinones with Expanded Activity Against the Fastidious Gram-Negative Organisms Haemophilus i nfluenzae and Moraxella c atarrhalis

Journal of medicinal chemistry, 2000-03, Vol.43 (5), p.953-970

2000

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Synthesis and antibacterial activity of new tropone-substituted phenyloxazolidinone antibacterial agents 2. Modification of the phenyl ring — the potentiating effect of fluorine substitution on in vivo activity

Bioorganic & medicinal chemistry letters, 1996-05, Vol.6 (9), p.1009-1014

1996

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Struktur-Wirkungs-Beziehungen von Oxazolidinonen: Grundlage der Entwicklung von Linezolid

Angewandte Chemie, 2003-05, Vol.115 (18), p.2056-2070

2003

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A Cross-cultural comparison of value systems and consumer ethics

Cross cultural management, 2005-12, Vol.12 (4), p.36-50

2005

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Oxazolidinone Structure-Activity Relationships Leading to Linezolid

Discovery and Characterization of QPT-1, the Progenitor of a New Class of Bacterial Topoisomerase Inhibitors

Synthesis and Antibacterial Activity of U-100592 and U-100766, Two Oxazolidinone Antibacterial Agents for the Potential Treatment of Multidrug-Resistant Gram-Positive Bacterial Infections

Efficacy of Linezolid in Treatment of Experimental Endocarditis Caused by Methicillin-Resistant Staphylococcus aureus

Piperazinyl Oxazolidinone Antibacterial Agents Containing a Pyridine, Diazene, or Triazene Heteroaromatic Ring

Identification of Staphylococcus aureus virulence genes in a murine model of bacteraemia using signature‐tagged mutagenesis

Virulence factor expression by Gram-positive cocci exposed to subinhibitory concentrations of linezolid

MICs of Oxazolidinones for Rhodococcus equi Strains Isolated from Humans and Animals

Identification of Phenylisoxazolines as Novel and Viable Antibacterial Agents Active against Gram-Positive Pathogens

The synthesis and antibacterial activity of 1,3,4-Thiadiazole phenyl oxazolidinone analogues

Antibacterial Oxazolidinones Possessing a Novel C-5 Side Chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic Acid Amide (PF-00422602), a New Lead Compound

Oxazolidinones: a new class of antibacterials

Identification of a Novel Oxazolidinone (U-100480) with Potent Antimycobacterial Activity

New Antibacterial tetrahydro-4(2 H)-thiopyran and thiomorpholine S-oxide and S, S-dioxide phenyloxazolidinones

Synthesis and biological evaluation of benzazepine oxazolidinone antibacterials

Efficacy of linezolid in a staphylococcal endocarditis rabbit model

The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones

Carbon–carbon-linked (pyrazolylphenyl)oxazolidinones with antibacterial activity against multiple drug resistant gram-positive and fastidious gram-negative bacteria

Substituent Effects on the Antibacterial Activity of Nitrogen−Carbon-Linked (Azolylphenyl)oxazolidinones with Expanded Activity Against the Fastidious Gram-Negative Organisms Haemophilus influenzae and Moraxella catarrhalis

Influence of Perceived Control over Time on College Students' Stress and Stress-Related Outcomes

Nitrogen−Carbon-Linked (Azolylphenyl)oxazolidinones with Potent Antibacterial Activity Against the Fastidious Gram-Negative Organisms Haemophilus influenzae and Moraxella catarrhalis

Substituent Effects on the Antibacterial Activity of Nitrogen−Carbon-Linked (Azolylphenyl)oxazolidinones with Expanded Activity Against the Fastidious Gram-Negative Organisms Haemophilus i nfluenzae and Moraxella c atarrhalis

Synthesis and antibacterial activity of new tropone-substituted phenyloxazolidinone antibacterial agents 2. Modification of the phenyl ring — the potentiating effect of fluorine substitution on in vivo activity

Struktur-Wirkungs-Beziehungen von Oxazolidinonen: Grundlage der Entwicklung von Linezolid

A Cross-cultural comparison of value systems and consumer ethics

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