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Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis

Cancer cell, 2015-07, Vol.28 (1), p.42-56

2015

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Rev-erbα heterozygosity produces a dose-dependent phenotypic advantage in mice

PloS one, 2020-05, Vol.15 (5), p.e0227720-e0227720

2020

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Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells

Science (American Association for the Advancement of Science), 2010-09, Vol.329 (5997), p.1345-1348

2010

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Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis

PloS one, 2014-07, Vol.9 (7), p.e101969-e101969

2014

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A two-hit model of alcoholic liver disease that exhibits rapid, severe fibrosis

PloS one, 2021-03, Vol.16 (3), p.e0249316

2021

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Fluorophore-NanoLuc BRET Reporters Enable Sensitive In Vivo Optical Imaging and Flow Cytometry for Monitoring Tumorigenesis

Cancer research (Chicago, Ill.), 2015-12, Vol.75 (23), p.5023-5033

2015

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Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

Toxicological sciences, 2010-05, Vol.115 (1), p.89-97

2010

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The Uremic Toxin 3-Indoxyl Sulfate Is a Potent Endogenous Agonist for the Human Aryl Hydrocarbon Receptor

Biochemistry (Easton), 2010-01, Vol.49 (2), p.393-400

2010

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LXR-inverse agonism stimulates immune-mediated tumor destruction by enhancing CD8 T-cell activity in triple negative breast cancer

Scientific reports, 2019-12, Vol.9 (1), p.19530-18, Article 19530

2019

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Ligand Selectivity and Gene Regulation by the Human Aryl Hydrocarbon Receptor in Transgenic Mice

Molecular pharmacology, 2009-06, Vol.75 (6), p.1412-1420

2009

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Pyrvinium Attenuates Hedgehog Signaling Downstream of Smoothened

Cancer research (Chicago, Ill.), 2014-09, Vol.74 (17), p.4811-4821

2014

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Combined regenerative rehabilitation improves recovery following volumetric muscle loss injury in a rat model

Journal of biomedical materials research. Part B, Applied biomaterials, 2024-07, Vol.112 (7), p.e35438-n/a

2024

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Inhibition of the key metabolic pathways, glycolysis and lipogenesis, of oral cancer by bitter melon extract

Cell communication and signaling, 2019-10, Vol.17 (1), p.131-13, Article 131

2019

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Differential Gene Regulation by the Human and Mouse Aryl Hydrocarbon Receptor

Toxicological sciences, 2010-04, Vol.114 (2), p.217-225

2010

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Pharmacological inhibition of REV-ERB stimulates differentiation, inhibits turnover and reduces fibrosis in dystrophic muscle

Scientific reports, 2017-12, Vol.7 (1), p.17142-13, Article 17142

2017

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Evidence for Ligand-Mediated Selective Modulation of Aryl Hydrocarbon Receptor Activity

Molecular pharmacology, 2010-02, Vol.77 (2), p.247-254

2010

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Retinal Degeneration: Short-Term Options and Long-Term Vision for Future Therapy

Missouri medicine, 2021-09, Vol.118 (5), p.466-472

2021

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CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibition

Cell reports (Cambridge), 2021-02, Vol.34 (8), p.108768-108768, Article 108768

2021

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The LXR inverse agonist SR9238 suppresses fibrosis in a model of non-alcoholic steatohepatitis

Molecular metabolism (Germany), 2015-04, Vol.4 (4), p.353-357

2015

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REV-ERB and ROR: therapeutic targets for treating myopathies

Physical biology, 2017-06, Vol.14 (4), p.045002-045002

2017

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Ah receptor represses acute-phase response gene expression without binding to its cognate response element

Laboratory investigation, 2009-06, Vol.89 (6), p.695-707

2009

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Antagonism of aryl hydrocarbon receptor signaling by 6,2',4'-trimethoxyflavone

The Journal of pharmacology and experimental therapeutics, 2010-01, Vol.332 (1), p.135-144

2010

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Inhibition of Hepatotoxicity by a LXR Inverse Agonist in a Model of Alcoholic Liver Disease

ACS pharmacology & translational science, 2018-09, Vol.1 (1), p.50-60

2018

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Rev-Erb co-regulates muscle regeneration via tethered interaction with the NF-Y cistrome

Molecular metabolism (Germany), 2017-07, Vol.6 (7), p.703-714

2017

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Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis

Rev-erbα heterozygosity produces a dose-dependent phenotypic advantage in mice

Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells

Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis

A two-hit model of alcoholic liver disease that exhibits rapid, severe fibrosis

Fluorophore-NanoLuc BRET Reporters Enable Sensitive In Vivo Optical Imaging and Flow Cytometry for Monitoring Tumorigenesis

Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

The Uremic Toxin 3-Indoxyl Sulfate Is a Potent Endogenous Agonist for the Human Aryl Hydrocarbon Receptor

LXR-inverse agonism stimulates immune-mediated tumor destruction by enhancing CD8 T-cell activity in triple negative breast cancer

International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily-Update 2023

Ligand Selectivity and Gene Regulation by the Human Aryl Hydrocarbon Receptor in Transgenic Mice

Pyrvinium Attenuates Hedgehog Signaling Downstream of Smoothened

Combined regenerative rehabilitation improves recovery following volumetric muscle loss injury in a rat model

Inhibition of the key metabolic pathways, glycolysis and lipogenesis, of oral cancer by bitter melon extract

Differential Gene Regulation by the Human and Mouse Aryl Hydrocarbon Receptor

Pharmacological inhibition of REV-ERB stimulates differentiation, inhibits turnover and reduces fibrosis in dystrophic muscle

Evidence for Ligand-Mediated Selective Modulation of Aryl Hydrocarbon Receptor Activity

Retinal Degeneration: Short-Term Options and Long-Term Vision for Future Therapy

CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibition

The LXR inverse agonist SR9238 suppresses fibrosis in a model of non-alcoholic steatohepatitis

REV-ERB and ROR: therapeutic targets for treating myopathies

Ah receptor represses acute-phase response gene expression without binding to its cognate response element

Antagonism of aryl hydrocarbon receptor signaling by 6,2',4'-trimethoxyflavone

Inhibition of Hepatotoxicity by a LXR Inverse Agonist in a Model of Alcoholic Liver Disease

Rev-Erb co-regulates muscle regeneration via tethered interaction with the NF-Y cistrome

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