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Human cardiovascular disease model predicts xanthine oxidase inhibitor cardiovascular risk

PloS one, 2023-09, Vol.18 (9), p.e0291330

2023

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Links Between Insulin Resistance, Adenosine A2B Receptors, and Inflammatory Markers in Mice and Humans

Diabetes (New York, N.Y.), 2011-02, Vol.60 (2), p.669-679

2011

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The A2B Adenosine Receptor Impairs the Maturation and Immunogenicity of Dendritic Cells

The Journal of immunology (1950), 2009-04, Vol.182 (8), p.4616-4623

2009

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Validation of a multicellular tumor microenvironment system for modeling patient tumor biology and drug response

Scientific reports, 2021-03, Vol.11 (1), p.5535-5535, Article 5535

2021

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Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis

JHEP reports, 2021-04, Vol.3 (2), p.100217-100217, Article 100217

2021

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Exposure of Induced Pluripotent Stem Cell‐Derived Vascular Endothelial and Smooth Muscle Cells in Coculture to Hemodynamics Induces Primary Vascular Cell‐Like Phenotypes

Stem cells translational medicine, 2017-08, Vol.6 (8), p.1673-1683

2017

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Transition State Analysis of the Coupling of Drug Transport to ATP Hydrolysis by P-glycoprotein

The Journal of biological chemistry, 2003-12, Vol.278 (52), p.52629-52640

2003

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Adenosine A2A receptor activation reduces recurrence and mortality from Clostridium difficile infection in mice following vancomycin treatment

BMC infectious diseases, 2012-12, Vol.12 (1), p.342-342

2012

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Drug-induced steatohepatitis

Expert opinion on drug metabolism & toxicology, 2017-02, Vol.13 (2), p.193-204

2017

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Biochemical and anaplerotic applications of in vitro models of propionic acidemia and methylmalonic acidemia using patient-derived primary hepatocytes

Molecular genetics and metabolism, 2020-07, Vol.130 (3), p.183-196

2020

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Development of a multicellular pancreatic tumor microenvironment system using patient-derived tumor cells

Lab on a chip, 2019-03, Vol.19 (7), p.1193-1204

2019

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Identification of 2,2-Dimethylbutanoic Acid (HST5040), a Clinical Development Candidate for the Treatment of Propionic Acidemia and Methylmalonic Acidemia

Journal of medicinal chemistry, 2021-04, Vol.64 (8), p.5037-5048

2021

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Development of an in vitro human liver system for interrogating nonalcoholic steatohepatitis

JCI insight, 2016-12, Vol.1 (20), p.e90954-e90954

2016

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A novel small molecule approach for the treatment of propionic and methylmalonic acidemias

Molecular genetics and metabolism, 2021-05, Vol.133 (1), p.71-82

2021

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Links between insulin resistance, adenosine [A.sub.2B] receptors, and inflammatory markers in mice and Humans.(ORIGINAL ARTICLE)

Diabetes (New York, N.Y.), 2011-02, Vol.60 (2), p.669

2011

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Genomic and biochemical analysis of repeatedly observed variants in DBT in individuals with maple syrup urine disease of Central American ancestry

American journal of medical genetics. Part A, 2022-09, Vol.188 (9), p.2738-2749

2022

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Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes

Chemico-biological interactions, 2016-08, Vol.255, p.31-44

2016

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An In Vitro Cynomolgus Vascular Surrogate System for Preclinical Drug Assessment and Human Translation

Arteriosclerosis, thrombosis, and vascular biology, 2015-10, Vol.35 (10), p.2185-2195

2015

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Contribution of adenosine A(2B) receptors in Clostridium difficile intoxication and infection

Infection and immunity, 2012-12, Vol.80 (12), p.4463-4473

2012

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Recapitulation of metabolic defects in a model of propionic acidemia using patient-derived primary hepatocytes

Molecular genetics and metabolism, 2016-03, Vol.117 (3), p.355-362

2016

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Evidence that the acute phase of ischemic preconditioning does not require signaling by the A2B adenosine receptor

Journal of molecular and cellular cardiology, 2010-11, Vol.49 (5), p.886-893

2010

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Contribution of Adenosine A2B Receptors in Clostridium difficile Intoxication and Infection

Infection and Immunity, 2012-12, Vol.80 (12), p.4463-4473

2012

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Improved Energy Coupling of Human P-glycoprotein by the Glycine 185 to Valine Mutation

Biochemistry (Easton), 2004-04, Vol.43 (13), p.3917-3928

2004

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Use of Chemical Chaperones in the Yeast Saccharomyces cerevisiae to Enhance Heterologous Membrane Protein Expression: High-Yield Expression and Purification of Human P-Glycoprotein

Archives of biochemistry and biophysics, 2000-04, Vol.376 (1), p.34-46

2000

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Are we putting too much stock in mice?

Journal of molecular and cellular cardiology, 2011-03, Vol.50 (3), p.584-585

2011

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Human cardiovascular disease model predicts xanthine oxidase inhibitor cardiovascular risk

Links Between Insulin Resistance, Adenosine A2B Receptors, and Inflammatory Markers in Mice and Humans

The A2B Adenosine Receptor Impairs the Maturation and Immunogenicity of Dendritic Cells

Validation of a multicellular tumor microenvironment system for modeling patient tumor biology and drug response

Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis

Exposure of Induced Pluripotent Stem Cell‐Derived Vascular Endothelial and Smooth Muscle Cells in Coculture to Hemodynamics Induces Primary Vascular Cell‐Like Phenotypes

Transition State Analysis of the Coupling of Drug Transport to ATP Hydrolysis by P-glycoprotein

Adenosine A2A receptor activation reduces recurrence and mortality from Clostridium difficile infection in mice following vancomycin treatment

Drug-induced steatohepatitis

Biochemical and anaplerotic applications of in vitro models of propionic acidemia and methylmalonic acidemia using patient-derived primary hepatocytes

Development of a multicellular pancreatic tumor microenvironment system using patient-derived tumor cells

Identification of 2,2-Dimethylbutanoic Acid (HST5040), a Clinical Development Candidate for the Treatment of Propionic Acidemia and Methylmalonic Acidemia

Development of an in vitro human liver system for interrogating nonalcoholic steatohepatitis

A novel small molecule approach for the treatment of propionic and methylmalonic acidemias

Links between insulin resistance, adenosine [A.sub.2B] receptors, and inflammatory markers in mice and Humans.(ORIGINAL ARTICLE)

Genomic and biochemical analysis of repeatedly observed variants in DBT in individuals with maple syrup urine disease of Central American ancestry

Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes

An In Vitro Cynomolgus Vascular Surrogate System for Preclinical Drug Assessment and Human Translation

Contribution of adenosine A(2B) receptors in Clostridium difficile intoxication and infection

Recapitulation of metabolic defects in a model of propionic acidemia using patient-derived primary hepatocytes

Evidence that the acute phase of ischemic preconditioning does not require signaling by the A2B adenosine receptor

Contribution of Adenosine A2B Receptors in Clostridium difficile Intoxication and Infection

Improved Energy Coupling of Human P-glycoprotein by the Glycine 185 to Valine Mutation

Use of Chemical Chaperones in the Yeast Saccharomyces cerevisiae to Enhance Heterologous Membrane Protein Expression: High-Yield Expression and Purification of Human P-Glycoprotein

Are we putting too much stock in mice?

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