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FGF/FGFR signaling in health and disease

Signal transduction and targeted therapy, 2020-09, Vol.5 (1), p.181, Article 181

2020

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Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway

Nature communications, 2020-01, Vol.11 (1), p.479-479, Article 479

2020

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Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway

Nature communications, 2021-07, Vol.12 (1), p.4391-4391, Article 4391

2021

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IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis

Experimental and Molecular Medicine, 2023, 55(0), , pp.2376-2389

2023

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FGFR3 deficiency enhances CXCL12-dependent chemotaxis of macrophages via upregulating CXCR7 and aggravates joint destruction in mice

Annals of the rheumatic diseases, 2020-01, Vol.79 (1), p.112-122

2020

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Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice

Arthritis & rheumatology (Hoboken, N.J.), 2012-12, Vol.64 (12), p.3982-3992

2012

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FGFR3 Deficiency Causes Multiple Chondroma-like Lesions by Upregulating Hedgehog Signaling

PLoS genetics, 2015-06, Vol.11 (6), p.e1005214-e1005214

2015

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Inhibition of aberrant Hif1α activation delays intervertebral disc degeneration in adult mice

Bone Research, 2022-01, Vol.10 (1), p.2-2, Article 2

2022

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Conditional Deletion of Fgfr3 in Chondrocytes leads to Osteoarthritis-like Defects in Temporomandibular Joint of Adult Mice

Scientific reports, 2016-04, Vol.6 (1), p.24039-24039, Article 24039

2016

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A novel fibroblast growth factor receptor 1 inhibitor protects against cartilage degradation in a murine model of osteoarthritis

Scientific reports, 2016-04, Vol.6 (1), p.24042-24042, Article 24042

2016

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Expansion of FGFR3-positive nucleus pulposus cells plays important roles in postnatal nucleus pulposus growth and regeneration

Stem cell research & therapy, 2022-06, Vol.13 (1), p.227-227, Article 227

2022

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IRE1α regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization

Genes & diseases, 2024-01, Vol.11 (1), p.464-478

2024

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A novel FGFR3-binding peptide inhibits FGFR3 signaling and reverses the lethal phenotype of mice mimicking human thanatophoric dysplasia

Human molecular genetics, 2012-12, Vol.21 (26), p.5443-5455

2012

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Adeno-Associated Virus-Mediated RNAi against Mutant Alleles Attenuates Abnormal Calvarial Phenotypes in an Apert Syndrome Mouse Model

Molecular therapy. Nucleic acids, 2018-12, Vol.13, p.291-302

2018

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Localized all-cell knock-out (LACKO) strategy is needed for studying adult stage diseases

Transgenic research, 2012-12, Vol.21 (6), p.1159-1162

2012

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Imbalanced development of anterior and posterior thorax is a causative factor triggering scoliosis

Journal of orthopaedic translation, 2019-04, Vol.17, p.103-111

2019

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Generation of Fgfr3 conditional knockout mice

International journal of biological sciences, 2010-01, Vol.6 (4), p.327-332

2010

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Functional characterization of a cotton late embryogenesis-abundant D113 gene promoter in transgenic tobacco

Plant cell reports, 2008-04, Vol.27 (4), p.707-717

2008

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Role of FGFR2 in calvarial defect healing

Journal of orthopaedic translation, 2016-10, Vol.7 (C), p.118-118

2016

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Cross-sectional studies of the causal link between asthma and osteoporosis: insights from Mendelian randomization and bioinformatics analysis

Osteoporosis international, 2024-06, Vol.35 (6), p.1007-1017

2024

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Loss of Fgfr1 in chondrocytes inhibits osteoarthritis by promoting autophagic activity in temporomandibular joint

The Journal of biological chemistry, 2018-06, Vol.293 (23), p.8761-8774

2018

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Inactivation of Vhl in Osteochondral Progenitor Cells Causes High Bone Mass Phenotype and Protects Against Age‐Related Bone Loss in Adult Mice

Journal of bone and mineral research, 2014-04, Vol.29 (4), p.820-829

2014

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Treating Autoimmune Inflammatory Diseases with an siERN1-Nanoprodrug That Mediates Macrophage Polarization and Blocks Toll-like Receptor Signaling

ACS nano, 2021-10, Vol.15 (10), p.15874-15891

2021

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Anemonin attenuates osteoarthritis progression through inhibiting the activation of IL‐1β/NF‐κB pathway

Journal of cellular and molecular medicine, 2017-12, Vol.21 (12), p.3231-3243

2017

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An Hsp70 promoter–based mouse for heat shock–induced gene modulation

Journal of molecular medicine (Berlin, Germany), 2024-05, Vol.102 (5), p.693-707

2024

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FGF/FGFR signaling in health and disease

Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway

Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway

IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis

FGFR3 deficiency enhances CXCL12-dependent chemotaxis of macrophages via upregulating CXCR7 and aggravates joint destruction in mice

Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice

FGFR3 Deficiency Causes Multiple Chondroma-like Lesions by Upregulating Hedgehog Signaling

Inhibition of aberrant Hif1α activation delays intervertebral disc degeneration in adult mice

Conditional Deletion of Fgfr3 in Chondrocytes leads to Osteoarthritis-like Defects in Temporomandibular Joint of Adult Mice

A novel fibroblast growth factor receptor 1 inhibitor protects against cartilage degradation in a murine model of osteoarthritis

Expansion of FGFR3-positive nucleus pulposus cells plays important roles in postnatal nucleus pulposus growth and regeneration

IRE1α regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization

A novel FGFR3-binding peptide inhibits FGFR3 signaling and reverses the lethal phenotype of mice mimicking human thanatophoric dysplasia

Adeno-Associated Virus-Mediated RNAi against Mutant Alleles Attenuates Abnormal Calvarial Phenotypes in an Apert Syndrome Mouse Model

Localized all-cell knock-out (LACKO) strategy is needed for studying adult stage diseases

Imbalanced development of anterior and posterior thorax is a causative factor triggering scoliosis

Generation of Fgfr3 conditional knockout mice

Functional characterization of a cotton late embryogenesis-abundant D113 gene promoter in transgenic tobacco

Role of FGFR2 in calvarial defect healing

Cross-sectional studies of the causal link between asthma and osteoporosis: insights from Mendelian randomization and bioinformatics analysis

Loss of Fgfr1 in chondrocytes inhibits osteoarthritis by promoting autophagic activity in temporomandibular joint

Inactivation of Vhl in Osteochondral Progenitor Cells Causes High Bone Mass Phenotype and Protects Against Age‐Related Bone Loss in Adult Mice

Treating Autoimmune Inflammatory Diseases with an siERN1-Nanoprodrug That Mediates Macrophage Polarization and Blocks Toll-like Receptor Signaling

Anemonin attenuates osteoarthritis progression through inhibiting the activation of IL‐1β/NF‐κB pathway

An Hsp70 promoter–based mouse for heat shock–induced gene modulation

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