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Activation and allosteric modulation of a muscarinic acetylcholine receptor

Nature (London), 2013-12, Vol.504 (7478), p.101-106

2013

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Crystal structures of the M1 and M4 muscarinic acetylcholine receptors

Nature (London), 2016-03, Vol.531 (7594), p.335-340

2016

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The Opioid Crisis and the Future of Addiction and Pain Therapeutics

The Journal of pharmacology and experimental therapeutics, 2019-11, Vol.371 (2), p.396-408

2019

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Probe dependence in the allosteric modulation of a G protein-coupled receptor: implications for detection and validation of allosteric ligand effects

Molecular pharmacology, 2012-01, Vol.81 (1), p.41-52

2012

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Selective Muscarinic Receptor Agonist Xanomeline as a Novel Treatment Approach for Schizophrenia

The American journal of psychiatry, 2008-08, Vol.165 (8), p.1033-1039

2008

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Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus

Cerebral cortex (New York, N.Y. 1991), 2016-01, Vol.26 (1), p.414-426

2016

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Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs

Nature communications, 2019-07, Vol.10 (1), p.3289-9, Article 3289

2019

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Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR

Nature communications, 2023-09, Vol.14 (1), p.5440-11, Article 5440

2023

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M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss

The Journal of clinical investigation, 2017-02, Vol.127 (2), p.487-499

2017

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Identification, expression and functional characterization of M4L, a muscarinic acetylcholine M4 receptor splice variant

PloS one, 2017-12, Vol.12 (12), p.e0188330-e0188330

2017

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New Insights into the Function of M4 Muscarinic Acetylcholine Receptors Gained Using a Novel Allosteric Modulator and a DREADD (Designer Receptor Exclusively Activated by a Designer Drug)

Molecular pharmacology, 2008-10, Vol.74 (4), p.1119

2008

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Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor

The Journal of pharmacology and experimental therapeutics, 2002-06, Vol.301 (3), p.1020-1024

2002

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Muscarinic Acetylcholine Receptor Agonists as Novel Treatments for Schizophrenia

The American journal of psychiatry, 2022-09, Vol.179 (9), p.611-627

2022

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Further Evaluation of Mechanisms Associated with the Antidepressantlike Signature of Scopolamine in Mice

CNS & neurological disorders drug targets, 2017-01, Vol.16 (4), p.492

2017

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Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB2 receptor

European journal of pharmacology, 2000-05, Vol.396 (2-3), p.141-149

2000

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Muscarinic acetylcholine receptors for psychotic disorders: bench-side to clinic

Trends in pharmacological sciences (Regular ed.), 2022-12, Vol.43 (12), p.1098-1112

2022

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Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean

Nature (London), 2001-03, Vol.410 (6825), p.207-212

2001

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Characterization of PCS1055, a novel muscarinic M4 receptor antagonist

European journal of pharmacology, 2016-07, Vol.782, p.70-76

2016

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Antipsychotic-like effect of the muscarinic acetylcholine receptor agonist BuTAC in non-human primates

PloS one, 2015-04, Vol.10 (4), p.e0122722-e0122722

2015

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Therapeutic Opportunities for Muscarinic Receptors in the Central Nervous System

Journal of medicinal chemistry, 2000-11, Vol.43 (23), p.4333-4353

2000

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Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system

Neurochemical research, 2003-04, Vol.28 (3-4), p.437-442

2003

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The impact of external innovation on new drug approvals: A retrospective analysis

International journal of pharmaceutics, 2019-05, Vol.563, p.273-281

2019

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Current status of muscarinic M1 and M4 receptors as drug targets for neurodegenerative diseases

Neuropharmacology, 2018-07, Vol.136 (Pt C), p.449-458

2018

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Structural basis of efficacy-driven ligand selectivity at GPCRs

Nature chemical biology, 2023-07, Vol.19 (7), p.805-814

2023

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Understanding Why Muscarinic Receptor Agonists Have Antipsychotic Properties

CNS spectrums, 2022-04, Vol.27 (2), p.249-249

2022

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Activation and allosteric modulation of a muscarinic acetylcholine receptor

Crystal structures of the M1 and M4 muscarinic acetylcholine receptors

The Opioid Crisis and the Future of Addiction and Pain Therapeutics

Probe dependence in the allosteric modulation of a G protein-coupled receptor: implications for detection and validation of allosteric ligand effects

Selective Muscarinic Receptor Agonist Xanomeline as a Novel Treatment Approach for Schizophrenia

Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus

Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs

Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR

M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss

Identification, expression and functional characterization of M4L, a muscarinic acetylcholine M4 receptor splice variant

New Insights into the Function of M4 Muscarinic Acetylcholine Receptors Gained Using a Novel Allosteric Modulator and a DREADD (Designer Receptor Exclusively Activated by a Designer Drug)

Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor

Muscarinic Acetylcholine Receptor Agonists as Novel Treatments for Schizophrenia

Further Evaluation of Mechanisms Associated with the Antidepressantlike Signature of Scopolamine in Mice

Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB2 receptor

Muscarinic acetylcholine receptors for psychotic disorders: bench-side to clinic

Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean

Characterization of PCS1055, a novel muscarinic M4 receptor antagonist

Antipsychotic-like effect of the muscarinic acetylcholine receptor agonist BuTAC in non-human primates

Therapeutic Opportunities for Muscarinic Receptors in the Central Nervous System

Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system

The impact of external innovation on new drug approvals: A retrospective analysis

Current status of muscarinic M1 and M4 receptors as drug targets for neurodegenerative diseases

Structural basis of efficacy-driven ligand selectivity at GPCRs

Understanding Why Muscarinic Receptor Agonists Have Antipsychotic Properties

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