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Tissue factor pathway inhibitor reduces mortality from Escherichia coli septic shock

The Journal of clinical investigation, 1993-06, Vol.91 (6), p.2850-2860

1993

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Assessment of platelet function assays

The American heart journal, 1998-05, Vol.135 (5), p.S170-S178

1998

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SC-54684A : an orally active inhibitor of platelet aggregation

Circulation (New York, N.Y.), 1995-01, Vol.91 (2), p.403-410

1995

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Extended inhibition of platelet aggregation with the orally active platelet inhibitor SC-54684A

Circulation (New York, N.Y.), 1995-01, Vol.91 (2), p.411-416

1995

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Prevention of reoccluding platelet-rich thrombi in canine femoral arteries with a novel peptide antagonist of platelet glycoprotein IIb/IIIa receptors

Circulation (New York, N.Y.), 1989-12, Vol.80 (6), p.1775-1782

1989

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Thrombosis triggered by severe arterial lesions is inhibited by oral administration of a glycoprotein IIb/IIIa antagonist

European journal of clinical investigation, 1997-07, Vol.27 (7), p.568-574

1997

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The protective dose of the potent GPIIb/IIIa antagonist SC-54701A is reduced when used in combination with aspirin and heparin in a canine model of coronary artery thrombosis

Circulation (New York, N.Y.), 1996, Vol.93 (1), p.129-134

1996

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Platelet GPIIb/IIIa receptor inhibition by SC-49992 prevents thrombosis and rethrombosis in the canine carotid artery

Cardiovascular research, 1993-03, Vol.27 (3), p.500-507

1993

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Protective effect of oral xemilofiban in arterial thrombosis in dogs: Increased activity in combination with aspirin

Circulation (New York, N.Y.), 1998-08, Vol.98 (8), p.813-820

1998

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SC-49992, a mimetic of the peptide arginine-glycine-aspartic acid-phenylalanine that blocks platelet aggregation, enhances recombinant tissue plasminogen activator-induced thrombolysis and prevents reocclusion in a canine model of coronary artery thrombosis

The Journal of pharmacology and experimental therapeutics, 1993-12, Vol.267 (3), p.1191

1993

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Potent in vitro and in vivo inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. A proposal on the nature of the binding interaction between the Arg-guanidine of RGDX mimetics and the platelet GP IIb-IIIa receptor

Journal of medicinal chemistry, 1993-06, Vol.36 (13), p.1811-1819

1993

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A mimetic of the RGDF-peptide [arginine-glycine-aspartic acid-phenylalanine] blocks aggregation and flow-induced platelet deposition on severely injured stenotic arterial wall. Effects on different animal models and in humans

Thrombosis research, 1996, Vol.81 (1), p.101-112

1996

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Differential effects of leukotrienes C4, D4 and E4 in the canine renal and mesenteric vascular beds

The Journal of pharmacology and experimental therapeutics, 1983-06, Vol.225 (3), p.682

Feigen, L P

1983

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Fibrinogen mediates platelet-polymorphonuclear leukocyte cooperation during immune-complex glomerulonephritis in rats

The Journal of clinical investigation, 1994-09, Vol.94 (3), p.928-936

1994

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A new method for measurement of plasma concentration of orally active glycoprotein IIb/IIIa antagonists

Thrombosis research, 1994-08, Vol.75 (4), p.409-417

1994

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Influence of renal lipoxygenase activity on the renal vascular response to arachidonic acid

The Journal of pharmacology and experimental therapeutics, 1984-01, Vol.228 (1), p.140

Feigen, L P

1984

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Pulmonary and systemic vasodilator effects of the newly discovered prostaglandin, PGI2

Journal of applied physiology (1985), 1978-09, Vol.45 (3), p.408-413

1978

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SC-49992-A potent and specific inhibitor of platelet aggregation

Thrombosis research, 1994-06, Vol.74 (5), p.523-535

1994

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Species variation in the effect of glycoprotein IIb/IIIa antagonists on inhibition of platelet aggregation

Journal of pharmacological and toxicological methods, 1993-09, Vol.30 (1), p.47-53

1993

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Differential effects of ibuprofen and indomethacin in the regional circulation of the dog

The Journal of pharmacology and experimental therapeutics, 1981-12, Vol.219 (3), p.679

1981

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In vitro and in vivo effects of a peptide mimetic (SC-47643) of RGD as an antiplatelet and antithrombotic agent

Thrombosis research, 1991-06, Vol.62 (5), p.567-578

1991

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Antiplatelet and antithrombotic effects of platelet glycoprotein IIb/IIIa (GPIIb/IIIa) inhibition by arginine-glycine-aspartic acid-serine (RGDS) and arginine-glycine-aspartic acid (RGD) (O-me)Y (SC-46749)

The Journal of pharmacology and experimental therapeutics, 1991-03, Vol.256 (3), p.876

1991

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Characterization of Binding of an RGD Mimetic, [3H]-SC-52012, to Platelet GPIIb/IIIa

Platelets (Edinburgh), 1995, Vol.6 (5), p.288-295

1995

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Renal vascular effects of endoperoxide analogs, prostaglandins, and arachidonic acid

American journal of physiology. Heart and circulatory physiology, 1977-11, Vol.233 (5), p.H573-H579

1977

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Differential effects of prostaglandins in the mesenteric vascular bed

American journal of physiology. Heart and circulatory physiology, 1978-09, Vol.235 (3), p.H326-H332

1978

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(23)
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Cardiac & Cardiovascular Systems
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Blood. Blood Coagulation. Reticuloendothelial System
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Pharmacology & Pharmacy
(15)
Platelet Aggregation Inhibitors - Pharmacology
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Rats
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Amino Acid Sequence
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Molecular Sequence Data
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Platelet Aggregation - Drug Effects
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Electrocardiography
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Tissue factor pathway inhibitor reduces mortality from Escherichia coli septic shock

Assessment of platelet function assays

SC-54684A : an orally active inhibitor of platelet aggregation

Extended inhibition of platelet aggregation with the orally active platelet inhibitor SC-54684A

Prevention of reoccluding platelet-rich thrombi in canine femoral arteries with a novel peptide antagonist of platelet glycoprotein IIb/IIIa receptors

Thrombosis triggered by severe arterial lesions is inhibited by oral administration of a glycoprotein IIb/IIIa antagonist

The protective dose of the potent GPIIb/IIIa antagonist SC-54701A is reduced when used in combination with aspirin and heparin in a canine model of coronary artery thrombosis

Platelet GPIIb/IIIa receptor inhibition by SC-49992 prevents thrombosis and rethrombosis in the canine carotid artery

Protective effect of oral xemilofiban in arterial thrombosis in dogs: Increased activity in combination with aspirin

SC-49992, a mimetic of the peptide arginine-glycine-aspartic acid-phenylalanine that blocks platelet aggregation, enhances recombinant tissue plasminogen activator-induced thrombolysis and prevents reocclusion in a canine model of coronary artery thrombosis

Potent in vitro and in vivo inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. A proposal on the nature of the binding interaction between the Arg-guanidine of RGDX mimetics and the platelet GP IIb-IIIa receptor

A mimetic of the RGDF-peptide [arginine-glycine-aspartic acid-phenylalanine] blocks aggregation and flow-induced platelet deposition on severely injured stenotic arterial wall. Effects on different animal models and in humans

Differential effects of leukotrienes C4, D4 and E4 in the canine renal and mesenteric vascular beds

Fibrinogen mediates platelet-polymorphonuclear leukocyte cooperation during immune-complex glomerulonephritis in rats

A new method for measurement of plasma concentration of orally active glycoprotein IIb/IIIa antagonists

Influence of renal lipoxygenase activity on the renal vascular response to arachidonic acid

Pulmonary and systemic vasodilator effects of the newly discovered prostaglandin, PGI2

SC-49992-A potent and specific inhibitor of platelet aggregation

Species variation in the effect of glycoprotein IIb/IIIa antagonists on inhibition of platelet aggregation

Differential effects of ibuprofen and indomethacin in the regional circulation of the dog

In vitro and in vivo effects of a peptide mimetic (SC-47643) of RGD as an antiplatelet and antithrombotic agent

Antiplatelet and antithrombotic effects of platelet glycoprotein IIb/IIIa (GPIIb/IIIa) inhibition by arginine-glycine-aspartic acid-serine (RGDS) and arginine-glycine-aspartic acid (RGD) (O-me)Y (SC-46749)

Characterization of Binding of an RGD Mimetic, [3H]-SC-52012, to Platelet GPIIb/IIIa

Renal vascular effects of endoperoxide analogs, prostaglandins, and arachidonic acid

Differential effects of prostaglandins in the mesenteric vascular bed

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