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Carrier-mediated membrane transport of folates in mammalian cells

Annual review of nutrition, 1999-01, Vol.19 (1), p.91-122

1999

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Efficacy of Cytotoxic Agents against Human Tumor Xenografts Is Markedly Enhanced By Coadministration of ZD1839 (Iressa), an Inhibitor of EGFR Tyrosine Kinase

Clinical cancer research, 2000-12, Vol.6 (12), p.4885-4892

2000

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The Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 Selectively Potentiates Radiation Response of Human Tumors in Nude Mice, with a Marked Improvement in Therapeutic Index

Clinical cancer research, 2003-09, Vol.9 (10), p.3773-3778

2003

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Adaptive regulation of intestinal folate uptake: effect of dietary folate deficiency

American Journal of Physiology: Cell Physiology, 2000-12, Vol.279 (6), p.C1889-C1895

2000

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A Phase 1 Study of Pralatrexate in Combination with Paclitaxel or Docetaxel in Patients with Advanced Solid Tumors

Clinical cancer research, 2007-05, Vol.13 (9), p.2692-2698

2007

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A phase I trial of intermittent high-dose gefitinib and fixed-dose docetaxel in patients with advanced solid tumors

Cancer chemotherapy and pharmacology, 2007-03, Vol.59 (4), p.467-475

2007

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Activity of a Novel Anti-folate (PDX, 10-propargyl 10-deazaaminopterin) against Human Lymphoma is Superior to Methotrexate and Correlates with Tumor RFC-1 Gene Expression

Leukemia & lymphoma, 2003-01, Vol.44 (6), p.1027-1035

2003

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10-Propargyl-10-deazaaminopterin: An antifolate with activity in Patients with previously treated non-small cell lung cancer

Clinical cancer research, 2003-06, Vol.9 (6), p.2072-2078

2003

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Phase I and Pharmacokinetic Study of 10-Propargyl-10-deazaaminopterin, a New Antifolate

Clinical cancer research, 2000-09, Vol.6 (9), p.3493-3498

2000

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RFC-1 Gene Expression Regulates Folate Absorption in Mouse Small Intestine

The Journal of biological chemistry, 1997-04, Vol.272 (17), p.11165-11170

1997

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Co-administration of Probenecid, an Inhibitor of a cMOAT/MRP- like Plasma Membrane ATPase, Greatly Enhanced the Efficacy of a New 10-Deazaaminopterin against Human Solid Tumors in Vivo

Clinical cancer research, 2000-09, Vol.6 (9), p.3705-3712

2000

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A new analogue of 10-deazaaminopterin with markedly enhanced curative effects against human tumor xenografts in mice

Cancer chemotherapy and pharmacology, 1998, Vol.42 (4), p.313-318

1998

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Structural analysis of the human RFC-1 gene encoding a folate transporter reveals multiple promoters and alternatively spliced transcripts with 5′ end heterogeneity

Gene, 1998-05, Vol.211 (2), p.331-341

1998

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Despite some expression of folate receptor α in human mesothelioma cells, internalization of methotrexate is predominantly carrier mediated

The Journal of thoracic and cardiovascular surgery, 2002-05, Vol.123 (5), p.862-868

2002

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Pralatrexate with Vitamin Supplementation in Patients with Previously Treated, Advanced Non-small Cell Lung Cancer: Safety and Efficacy in a Phase 1 Trial

Journal of thoracic oncology, 2011-11, Vol.6 (11), p.1915-1922

2011

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A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues. Implications for intrinsic antifolate resistance and directional orientation of the transporter within the plasma membrane of tumor cells

The Journal of biological chemistry, 1998-01, Vol.273 (5), p.2526-2531

1998

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Augmentation of Apoptosis and Tumor Regression by Flavopiridol in the Presence of CPT-11 in Hct116 Colon Cancer Monolayers and Xenografts

Clinical cancer research, 2001-12, Vol.7 (12), p.4209-4219

2001

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Phase II Trial of Pralatrexate (10-Propargyl-10-deazaaminopterin, PDX) in Patients with Unresectable Malignant Pleural Mesothelioma

Journal of thoracic oncology, 2007-04, Vol.2 (4), p.317-320

2007

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Regulation of transcription of the murine gamma-glutamyl hydrolase gene. Delineation of core promoter A and the role of LYF-1, E2F and ETS-1 in determining tumor-specific expression

Gene, 2002-05, Vol.291 (1-2), p.169-176

2002

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Experimental therapeutics with a new 10-deazaaminopterin in human mesothelioma: further improving efficacy through structural design, pharmacologic modulation at the level of MRP ATPases, and combined therapy with platinums

Clinical cancer research, 2001-10, Vol.7 (10), p.3199

2001

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9-Substituted acridine derivatives with long half-life and potent antitumor activity: synthesis and structure-activity relationships

Journal of medicinal chemistry, 1995-08, Vol.38 (17), p.3226-3235

1995

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Microarray analysis of prostate cancer progression to reduced androgen dependence: Studies in unique models contrasts early and late molecular events

Molecular carcinogenesis, 2004-11, Vol.41 (3), p.150-163

2004

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Obligate genetic expression in tumor cells of a fetal membrane property mediating folate transport: biological significance and implications for improved therapy of human cancer

Cancer research (Chicago, Ill.), 1985-09, Vol.45 (9), p.3992-4000

SIROTNAK, F. M

1985

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Enhancing cytotoxic sensitivity of tumor cells to antifolates: another opportunity for gene therapy?

JNCI : Journal of the National Cancer Institute, 1999-07, Vol.91 (14), p.1178-1179

Sirotnak, F M

1999

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A new human peptide deformylase inhibitable by actinonin

Biochemical and biophysical research communications, 2003-12, Vol.312 (2), p.309-315

2003

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Carrier-mediated membrane transport of folates in mammalian cells

Efficacy of Cytotoxic Agents against Human Tumor Xenografts Is Markedly Enhanced By Coadministration of ZD1839 (Iressa), an Inhibitor of EGFR Tyrosine Kinase

The Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 Selectively Potentiates Radiation Response of Human Tumors in Nude Mice, with a Marked Improvement in Therapeutic Index

Adaptive regulation of intestinal folate uptake: effect of dietary folate deficiency

A Phase 1 Study of Pralatrexate in Combination with Paclitaxel or Docetaxel in Patients with Advanced Solid Tumors

A phase I trial of intermittent high-dose gefitinib and fixed-dose docetaxel in patients with advanced solid tumors

Activity of a Novel Anti-folate (PDX, 10-propargyl 10-deazaaminopterin) against Human Lymphoma is Superior to Methotrexate and Correlates with Tumor RFC-1 Gene Expression

10-Propargyl-10-deazaaminopterin: An antifolate with activity in Patients with previously treated non-small cell lung cancer

Phase I and Pharmacokinetic Study of 10-Propargyl-10-deazaaminopterin, a New Antifolate

RFC-1 Gene Expression Regulates Folate Absorption in Mouse Small Intestine

Co-administration of Probenecid, an Inhibitor of a cMOAT/MRP- like Plasma Membrane ATPase, Greatly Enhanced the Efficacy of a New 10-Deazaaminopterin against Human Solid Tumors in Vivo

A new analogue of 10-deazaaminopterin with markedly enhanced curative effects against human tumor xenografts in mice

Structural analysis of the human RFC-1 gene encoding a folate transporter reveals multiple promoters and alternatively spliced transcripts with 5′ end heterogeneity

Despite some expression of folate receptor α in human mesothelioma cells, internalization of methotrexate is predominantly carrier mediated

Pralatrexate with Vitamin Supplementation in Patients with Previously Treated, Advanced Non-small Cell Lung Cancer: Safety and Efficacy in a Phase 1 Trial

A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues. Implications for intrinsic antifolate resistance and directional orientation of the transporter within the plasma membrane of tumor cells

Augmentation of Apoptosis and Tumor Regression by Flavopiridol in the Presence of CPT-11 in Hct116 Colon Cancer Monolayers and Xenografts

Phase II Trial of Pralatrexate (10-Propargyl-10-deazaaminopterin, PDX) in Patients with Unresectable Malignant Pleural Mesothelioma

Regulation of transcription of the murine gamma-glutamyl hydrolase gene. Delineation of core promoter A and the role of LYF-1, E2F and ETS-1 in determining tumor-specific expression

Experimental therapeutics with a new 10-deazaaminopterin in human mesothelioma: further improving efficacy through structural design, pharmacologic modulation at the level of MRP ATPases, and combined therapy with platinums

9-Substituted acridine derivatives with long half-life and potent antitumor activity: synthesis and structure-activity relationships

Microarray analysis of prostate cancer progression to reduced androgen dependence: Studies in unique models contrasts early and late molecular events

Obligate genetic expression in tumor cells of a fetal membrane property mediating folate transport: biological significance and implications for improved therapy of human cancer

Enhancing cytotoxic sensitivity of tumor cells to antifolates: another opportunity for gene therapy?

A new human peptide deformylase inhibitable by actinonin

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