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Overestimation of N‐glycoPEGylated factor IX activity in a one‐stage factor IX clotting assay owing to silica‐mediated premature conversion to activated factor IX

Journal of thrombosis and haemostasis, 2016-07, Vol.14 (7), p.1420-1427

2016

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Measuring FVIII activity of glycopegylated recombinant factor VIII, N8‐GP, with commercially available one‐stage clotting and chromogenic assay kits: a two‐centre study

Haemophilia : the official journal of the World Federation of Hemophilia, 2017-05, Vol.23 (3), p.458-465

2017

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Factor VIII chromogenic assays can be used for potency labeling and postadministration monitoring of N8‐GP

Journal of thrombosis and haemostasis, 2016-08, Vol.14 (8), p.1579-1587

2016

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Qualification of a select one‐stage activated partial thromboplastin time‐based clotting assay and two chromogenic assays for the post‐administration monitoring of nonacog beta pegol

Journal of thrombosis and haemostasis, 2017-10, Vol.15 (10), p.1901-1912

2017

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Measuring factor IX activity of nonacog beta pegol with commercially available one‐stage clotting and chromogenic assay kits: a two‐center study

Journal of thrombosis and haemostasis, 2016-07, Vol.14 (7), p.1428-1435

2016

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Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies

Journal of thrombosis and haemostasis, 2016-05, Vol.14 (5), p.894-905

2016

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Human platelets express endothelial protein C receptor, which can be utilized to enhance localization of factor VIIa activity

Journal of thrombosis and haemostasis, 2018-09, Vol.16 (9), p.1817-1829

2018

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International comparative field study of N8 evaluating factor VIII assay performance

Haemophilia : the official journal of the World Federation of Hemophilia, 2011-07, Vol.17 (4), p.695-702

2011

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Factor IX-deficient plasma spiked with N9-GP behaves similarly to N9-GP post-administration clinical samples in N9-GP ELISA and FIX activity assays

Haemophilia : the official journal of the World Federation of Hemophilia, 2015-11, Vol.21 (6), p.832-836

2015

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Thrombin generation assay using factor XIa to measure factors VIII and IX and their glycoPEGylated derivatives is robust and sensitive

Journal of thrombosis and haemostasis, 2015-11, Vol.13 (11), p.2041-2052

2015

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A comparative analysis of heterogeneity in commercially available recombinant factor VIII products

Haemophilia : the official journal of the World Federation of Hemophilia, 2018-11, Vol.24 (6), p.880-887

2018

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An activated factor VII variant with enhanced tissue factor‐independent activity speeds wound healing in a mouse hemophilia B model

Journal of thrombosis and haemostasis, 2016-06, Vol.14 (6), p.1249-1254

2016

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A sensitive venous bleeding model in haemophilia A mice: effects of two recombinant FVIII products (N8 and Advate®)

Haemophilia : the official journal of the World Federation of Hemophilia, 2012-09, Vol.18 (5), p.782-788

2012

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The pharmacokinetics and pharmacodynamics of single‐dose and multiple‐dose recombinant activated factor VII in patients with haemophilia A or B

Haemophilia : the official journal of the World Federation of Hemophilia, 2017-11, Vol.23 (6), p.868-876

2017

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Chromogenic analysis of FIX activity in haemophilia B patients treated with nonacog beta pegol

Haemophilia : the official journal of the World Federation of Hemophilia, 2017-11, Vol.23 (6), p.e528-e530

2017

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Recombinant human factor VIIa (rFVIIa) cleared principally by antithrombin following intravenous administration in hemophilia patients

Journal of thrombosis and haemostasis, 2011-02, Vol.9 (2), p.333-338

2011

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rFVIIa and a new enhanced rFVIIa‐analogue, NN1731, reduce bleeding in clopidogrel‐treated and in thrombocytopenic rats

Journal of thrombosis and haemostasis, 2009-04, Vol.7 (4), p.651-657

2009

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Faster onset of effect and greater efficacy of NN1731 compared with rFVIIa, aPCC and FVIII in tail bleeding in hemophilic mice

Journal of thrombosis and haemostasis, 2009-09, Vol.7 (9), p.1517-1522

2009

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Evaluation of the safety and pharmacokinetics of a fast‐acting recombinant FVIIa analogue, NN1731, in healthy male subjects

Journal of thrombosis and haemostasis, 2009-02, Vol.7 (2), p.299-305

2009

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Pharmacokinetics and pharmacodynamics of a new recombinant FVIII (N8) in haemophilia A mice

Haemophilia : the official journal of the World Federation of Hemophilia, 2012-01, Vol.18 (1), p.139-145

2012

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Functional characteristics of N8, a new recombinant FVIII

Haemophilia : the official journal of the World Federation of Hemophilia, 2010-11, Vol.16 (6), p.878-887

2010

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Pharmacokinetics and pharmacodynamics of turoctocog alfa and N8-GP in haemophilia A dogs

Haemophilia : the official journal of the World Federation of Hemophilia, 2012-11, Vol.18 (6), p.941-947

2012

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Platelet binding and activity of a factor VIIa variant with enhanced tissue factor independent activity

Journal of thrombosis and haemostasis, 2011-04, Vol.9 (4), p.759-766

2011

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Prolonged effect of a new O-glycoPEGylated FVIII (N8-GP) in a murine saphenous vein bleeding model

Haemophilia : the official journal of the World Federation of Hemophilia, 2013-11, Vol.19 (6), p.913-919

2013

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Activity and regulation of factor VIIa analogs with increased potency at the endothelial cell surface

Journal of thrombosis and haemostasis, 2007-02, Vol.5 (2), p.336-346

2007

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Overestimation of N‐glycoPEGylated factor IX activity in a one‐stage factor IX clotting assay owing to silica‐mediated premature conversion to activated factor IX

Measuring FVIII activity of glycopegylated recombinant factor VIII, N8‐GP, with commercially available one‐stage clotting and chromogenic assay kits: a two‐centre study

Factor VIII chromogenic assays can be used for potency labeling and postadministration monitoring of N8‐GP

Qualification of a select one‐stage activated partial thromboplastin time‐based clotting assay and two chromogenic assays for the post‐administration monitoring of nonacog beta pegol

Measuring factor IX activity of nonacog beta pegol with commercially available one‐stage clotting and chromogenic assay kits: a two‐center study

Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies

Human platelets express endothelial protein C receptor, which can be utilized to enhance localization of factor VIIa activity

International comparative field study of N8 evaluating factor VIII assay performance

Factor IX-deficient plasma spiked with N9-GP behaves similarly to N9-GP post-administration clinical samples in N9-GP ELISA and FIX activity assays

Thrombin generation assay using factor XIa to measure factors VIII and IX and their glycoPEGylated derivatives is robust and sensitive

A comparative analysis of heterogeneity in commercially available recombinant factor VIII products

An activated factor VII variant with enhanced tissue factor‐independent activity speeds wound healing in a mouse hemophilia B model

A sensitive venous bleeding model in haemophilia A mice: effects of two recombinant FVIII products (N8 and Advate®)

The pharmacokinetics and pharmacodynamics of single‐dose and multiple‐dose recombinant activated factor VII in patients with haemophilia A or B

Chromogenic analysis of FIX activity in haemophilia B patients treated with nonacog beta pegol

Recombinant human factor VIIa (rFVIIa) cleared principally by antithrombin following intravenous administration in hemophilia patients

rFVIIa and a new enhanced rFVIIa‐analogue, NN1731, reduce bleeding in clopidogrel‐treated and in thrombocytopenic rats

Faster onset of effect and greater efficacy of NN1731 compared with rFVIIa, aPCC and FVIII in tail bleeding in hemophilic mice

Evaluation of the safety and pharmacokinetics of a fast‐acting recombinant FVIIa analogue, NN1731, in healthy male subjects

Pharmacokinetics and pharmacodynamics of a new recombinant FVIII (N8) in haemophilia A mice

Functional characteristics of N8, a new recombinant FVIII

Pharmacokinetics and pharmacodynamics of turoctocog alfa and N8-GP in haemophilia A dogs

Platelet binding and activity of a factor VIIa variant with enhanced tissue factor independent activity

Prolonged effect of a new O-glycoPEGylated FVIII (N8-GP) in a murine saphenous vein bleeding model

Activity and regulation of factor VIIa analogs with increased potency at the endothelial cell surface

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