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ATR inhibition enables complete tumour regression in ALK-driven NB mouse models

Nature communications, 2021-11, Vol.12 (1), p.6813-6813, Article 6813

2021

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ALK signaling primes the DNA damage response sensitizing ALK-driven neuroblastoma to therapeutic ATR inhibition

Proceedings of the National Academy of Sciences - PNAS, 2024-01, Vol.121 (1), p.e2315242121-e2315242121

2024

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Quantification of Neoantigen-Mediated Immunoediting in Cancer Evolution-Letter

Cancer research (Chicago, Ill.), 2023-03, Vol.83 (6), p.971-972

2023

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Pharmacologic RNA splicing modulation: a novel mechanism to enhance neoantigen-directed anti-tumor immunity and immunotherapy response

Signal transduction and targeted therapy, 2021-10, Vol.6 (1), p.373-2, Article 373

2021

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Preclinical exploration of the DNA damage response pathway using the interactive neuroblastoma cell line explorer CLEAN

NAR cancer, 2024-03, Vol.6 (1)

2024

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Clinical response of the novel activating ALK-I1171T mutation in neuroblastoma to the ALK inhibitor ceritinib

Cold Spring Harbor molecular case studies, 2018-08, Vol.4 (4), p.a002550

2018

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Low immunogenicity of common cancer hot spot mutations resulting in false immunogenic selection signals

PLoS genetics, 2021-02, Vol.17 (2), p.e1009368-e1009368

2021

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Benchmark of tools for in silico prediction of MHC class I and class II genotypes from NGS data

BMC genomics, 2023-05, Vol.24 (1), p.247-247, Article 247

2023

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Recurrent promoter mutations in melanoma are defined by an extended context-specific mutational signature

PLoS genetics, 2017-05, Vol.13 (5), p.e1006773-e1006773

2017

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Somatic Mutation Patterns in Hemizygous Genomic Regions Unveil Purifying Selection during Tumor Evolution

PLoS genetics, 2016-12, Vol.12 (12), p.e1006506-e1006506

2016

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Elevated pyrimidine dimer formation at distinct genomic bases underlies promoter mutation hotspots in UV-exposed cancers

PLoS genetics, 2018-12, Vol.14 (12), p.e1007849-e1007849

2018

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MHC class II genotypes are independent predictors of anti-PD1 immunotherapy response in melanoma

Communications medicine, 2024-09, Vol.4 (1), p.184-8, Article 184

2024

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ALK ligand ALKAL2 potentiates MYCN‐driven neuroblastoma in the absence of ALK mutation

The EMBO journal, 2021-02, Vol.40 (3), p.e105784-n/a

2021

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Glycine and glycine receptor signalling in non-neuronal cells

Frontiers in molecular neuroscience, 2009-01, Vol.2, p.9-9

2009

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ALK fusion NSCLC oncogenes promote survival and inhibit NK cell responses via SERPINB4 expression

Proceedings of the National Academy of Sciences - PNAS, 2023-02, Vol.120 (8), p.e2216479120-e2216479120

2023

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Mutational Signatures Are Critical for Proper Estimation of Purifying Selection Pressures in Cancer Somatic Mutation Data When Using the dN/dS Metric

Frontiers in genetics, 2017-06, Vol.8 (JUN), p.74-74

2017

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Pan-cancer transcriptomic analysis associates long non-coding RNAs with key mutational driver events

Nature communications, 2016-10, Vol.7 (1), p.13197-13197, Article 13197

2016

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A clinically annotated post-mortem approach to study multi-organ somatic mutational clonality in normal tissues

Scientific reports, 2022-06, Vol.12 (1), p.10322-10322, Article 10322

2022

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Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic pathways

Science signaling, 2018-11, Vol.11 (557)

2018

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A systematic analysis of immune escape signals in the primary and metastatic tumor genome

Nature genetics, 2023-05, Vol.55 (5), p.728-729

Van den Eynden, Jimmy

2023

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Cancer evolution A systematic analysis of immune escape signals in the primary and metastatic tumor genome

Nature genetics, 2023-05, Vol.55 (5), p.728-729

Van den Eynden, Jimmy

2023

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11q Deletion or ALK Activity Curbs DLG2 Expression to Maintain an Undifferentiated State in Neuroblastoma

Cell reports (Cambridge), 2020-09, Vol.32 (12), p.108171-108171, Article 108171

2020

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Simultaneous discovery of cancer subtypes and subtype features by molecular data integration

Bioinformatics (Oxford, England), 2016-09, Vol.32 (17), p.i445-i454

2016

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Cancer genomics at the edge of public health and precision medicine in Belgium: A national perspective

Journal of clinical oncology, 2018-05, Vol.36 (15_suppl), p.e18543-e18543

Van den Bulcke, Marc

2018

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Loss of RET Promotes Mesenchymal Identity in Neuroblastoma Cells

Cancers, 2021-04, Vol.13 (8), p.1909

2021

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ATR inhibition enables complete tumour regression in ALK-driven NB mouse models

ALK signaling primes the DNA damage response sensitizing ALK-driven neuroblastoma to therapeutic ATR inhibition

Quantification of Neoantigen-Mediated Immunoediting in Cancer Evolution-Letter

Pharmacologic RNA splicing modulation: a novel mechanism to enhance neoantigen-directed anti-tumor immunity and immunotherapy response

Preclinical exploration of the DNA damage response pathway using the interactive neuroblastoma cell line explorer CLEAN

Clinical response of the novel activating ALK-I1171T mutation in neuroblastoma to the ALK inhibitor ceritinib

Low immunogenicity of common cancer hot spot mutations resulting in false immunogenic selection signals

Benchmark of tools for in silico prediction of MHC class I and class II genotypes from NGS data

Recurrent promoter mutations in melanoma are defined by an extended context-specific mutational signature

Somatic Mutation Patterns in Hemizygous Genomic Regions Unveil Purifying Selection during Tumor Evolution

Elevated pyrimidine dimer formation at distinct genomic bases underlies promoter mutation hotspots in UV-exposed cancers

MHC class II genotypes are independent predictors of anti-PD1 immunotherapy response in melanoma

ALK ligand ALKAL2 potentiates MYCN‐driven neuroblastoma in the absence of ALK mutation

Glycine and glycine receptor signalling in non-neuronal cells

ALK fusion NSCLC oncogenes promote survival and inhibit NK cell responses via SERPINB4 expression

Mutational Signatures Are Critical for Proper Estimation of Purifying Selection Pressures in Cancer Somatic Mutation Data When Using the dN/dS Metric

Pan-cancer transcriptomic analysis associates long non-coding RNAs with key mutational driver events

A clinically annotated post-mortem approach to study multi-organ somatic mutational clonality in normal tissues

Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic pathways

A systematic analysis of immune escape signals in the primary and metastatic tumor genome

Cancer evolution A systematic analysis of immune escape signals in the primary and metastatic tumor genome

11q Deletion or ALK Activity Curbs DLG2 Expression to Maintain an Undifferentiated State in Neuroblastoma

Simultaneous discovery of cancer subtypes and subtype features by molecular data integration

Cancer genomics at the edge of public health and precision medicine in Belgium: A national perspective

Loss of RET Promotes Mesenchymal Identity in Neuroblastoma Cells

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