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Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange

Proceedings of the National Academy of Sciences - PNAS, 2013-03, Vol.110 (13), p.5145-5150

2013

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Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose

Biotechnology and bioengineering, 2011-07, Vol.108 (7), p.1591-1602

2011

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Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen

Molecular cell, 2016-07, Vol.63 (1), p.135-145

2016

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Tandem Native Mass-Spectrometry on Antibody–Drug Conjugates and Submillion Da Antibody–Antigen Protein Assemblies on an Orbitrap EMR Equipped with a High-Mass Quadrupole Mass Selector

Analytical chemistry (Washington), 2015-06, Vol.87 (12), p.6095-6102

2015

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Enhancing Accuracy in Molecular Weight Determination of Highly Heterogeneously Glycosylated Proteins by Native Tandem Mass Spectrometry

Analytical chemistry (Washington), 2017-05, Vol.89 (9), p.4793-4797

2017

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Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

Nature biotechnology, 2009-08, Vol.27 (8), p.767-771

2009

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Controlled Fab-arm exchange for the generation of stable bispecific IgG1

Nature protocols, 2014-10, Vol.9 (10), p.2450-2463

2014

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Auranofin inhibition of thioredoxin reductase sensitizes lung neuroendocrine tumor cells (NETs) and small cell lung cancer (SCLC) cells to sorafenib as well as inhibiting SCLC xenograft growth

Cancer biology & therapy, 2024-12, Vol.25 (1), p.2382524

2024

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In-depth qualitative and quantitative analysis of composite glycosylation profiles and other micro-heterogeneity on intact monoclonal antibodies by high-resolution native mass spectrometry using a modified Orbitrap

mAbs, 2013-11, Vol.5 (6), p.917-924

2013

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Species-specific determinants in the IgG CH3 domain enable Fab-arm exchange by affecting the noncovalent CH3-CH3 interaction strength

The Journal of immunology (1950), 2011-09, Vol.187 (6), p.3238-3246

2011

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Biophysical Characterization and Stability of Modified IgG1 Antibodies with Different Hexamerization Propensities

Journal of pharmaceutical sciences, 2022-06, Vol.111 (6), p.1587-1598

2022

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Cysteine-SILAC Mass Spectrometry Enabling the Identification and Quantitation of Scrambled Interchain Disulfide Bonds: Preservation of Native Heavy-Light Chain Pairing in Bispecific IgGs Generated by Controlled Fab-arm Exchange

Analytical chemistry (Washington), 2017-10, Vol.89 (20), p.10873-10882

2017

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Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation

mAbs, 2015-07, Vol.7 (4), p.672-680

2015

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Quantitative Analysis of the Interaction Strength and Dynamics of Human IgG4 Half Molecules by Native Mass Spectrometry

Structure (London), 2011-09, Vol.19 (9), p.1274-1282

2011

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Production of stable bispecific IgG1 by controlled Fab-arm exchange: Scalability from bench to large-scale manufacturing by application of standard approaches

mAbs, 2013-11, Vol.5 (6), p.962-973

2013

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Inflammatory Biomarker Profiles in Very Preterm Infants within the Context of Preeclampsia, Chorioamnionitis, and Clinically Diagnosed Postnatal Infection

Pediatric reports, 2023-08, Vol.15 (3), p.483-493

2023

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Mutation of Y407 in the CH3 domain dramatically alters glycosylation and structure of human IgG

mAbs, 2013-03, Vol.5 (2), p.219-228

2013

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Is Childhood Sexual Abuse Related to Self-Injurious Behavior?

American family physician, 2011-12, Vol.84 (11), p.1195-1195

Ewald, T.M., MD

2011

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Chemokine Receptor CXCR4 Radioligand Targeted Therapy Using 177Lutetium-pentixather for Pulmonary Neuroendocrine Cancers

Radiation research, 2023-11, Vol.201 (1)

2023

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Intra-articular implantation of collagen scaffold carriers is safe in both native and arthrofibrotic rabbit knee joints

Bone & joint research, 2017-03, Vol.6 (3), p.162-171

2017

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Tissue mechanics regulate brain development, homeostasis and disease

Journal of cell science, 2017-01, Vol.130 (1), p.71-82

2017

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Embryo-epithelium interactions during implantation at a glance

Journal of cell science, 2017-01, Vol.130 (1), p.15-22

2017

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Detecting SPIT Calls by Checking Human Communication Patterns

2007 IEEE International Conference on Communications, 2007, p.1979-1984

2007

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Comminution of the dorsal metaphysis and its effects on the radiographic outcomes of distal radius fractures

The Journal of hand surgery, European volume, 2010-10, Vol.35 (8), p.652-658

2010

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Microtubules in 3D cell motility

Journal of cell science, 2017-01, Vol.130 (1), p.39-50

2017

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Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange

Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose

Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen

Tandem Native Mass-Spectrometry on Antibody–Drug Conjugates and Submillion Da Antibody–Antigen Protein Assemblies on an Orbitrap EMR Equipped with a High-Mass Quadrupole Mass Selector

Enhancing Accuracy in Molecular Weight Determination of Highly Heterogeneously Glycosylated Proteins by Native Tandem Mass Spectrometry

Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

Controlled Fab-arm exchange for the generation of stable bispecific IgG1

Auranofin inhibition of thioredoxin reductase sensitizes lung neuroendocrine tumor cells (NETs) and small cell lung cancer (SCLC) cells to sorafenib as well as inhibiting SCLC xenograft growth

In-depth qualitative and quantitative analysis of composite glycosylation profiles and other micro-heterogeneity on intact monoclonal antibodies by high-resolution native mass spectrometry using a modified Orbitrap

Species-specific determinants in the IgG CH3 domain enable Fab-arm exchange by affecting the noncovalent CH3-CH3 interaction strength

Biophysical Characterization and Stability of Modified IgG1 Antibodies with Different Hexamerization Propensities

Cysteine-SILAC Mass Spectrometry Enabling the Identification and Quantitation of Scrambled Interchain Disulfide Bonds: Preservation of Native Heavy-Light Chain Pairing in Bispecific IgGs Generated by Controlled Fab-arm Exchange

Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation

Quantitative Analysis of the Interaction Strength and Dynamics of Human IgG4 Half Molecules by Native Mass Spectrometry

Production of stable bispecific IgG1 by controlled Fab-arm exchange: Scalability from bench to large-scale manufacturing by application of standard approaches

Inflammatory Biomarker Profiles in Very Preterm Infants within the Context of Preeclampsia, Chorioamnionitis, and Clinically Diagnosed Postnatal Infection

Mutation of Y407 in the CH3 domain dramatically alters glycosylation and structure of human IgG

Is Childhood Sexual Abuse Related to Self-Injurious Behavior?

Chemokine Receptor CXCR4 Radioligand Targeted Therapy Using 177Lutetium-pentixather for Pulmonary Neuroendocrine Cancers

Intra-articular implantation of collagen scaffold carriers is safe in both native and arthrofibrotic rabbit knee joints

Tissue mechanics regulate brain development, homeostasis and disease

Embryo-epithelium interactions during implantation at a glance

Detecting SPIT Calls by Checking Human Communication Patterns

Comminution of the dorsal metaphysis and its effects on the radiographic outcomes of distal radius fractures

Microtubules in 3D cell motility

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