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The roles of DNA, RNA and histone methylation in ageing and cancer

Nature reviews. Molecular cell biology, 2019-10, Vol.20 (10), p.573-589

2019

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DNA Damage-Induced Primordial Follicle Oocyte Apoptosis and Loss of Fertility Require TAp63-Mediated Induction of Puma and Noxa

Molecular cell, 2012-11, Vol.48 (3), p.343-352

2012

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p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa

Cell reports (Cambridge), 2013-05, Vol.3 (5), p.1339-1345

2013

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Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer

Proceedings of the National Academy of Sciences - PNAS, 2015-07, Vol.112 (27), p.8409-8414

2015

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Dysregulation of histone methyltransferases in breast cancer – Opportunities for new targeted therapies?

Molecular oncology, 2016-12, Vol.10 (10), p.1497-1515

2016

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Developmental stage-specific contribution of LGR5+ cells to basal and luminal epithelial lineages in the postnatal mammary gland

The Journal of pathology, 2012-11, Vol.228 (3), p.300-309

2012

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ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim

Cell, 2007-06, Vol.129 (7), p.1337-1349

2007

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p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

Science (American Association for the Advancement of Science), 2003-11, Vol.302 (5647), p.1036-1038

2003

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Sudden cardiac death risk in hypertrophic cardiomyopathy: comparison between echocardiography and magnetic resonance imaging

Scientific reports, 2021-03, Vol.11 (1), p.7146-7146, Article 7146

2021

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Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids

PLoS biology, 2018-08, Vol.16 (8), p.e2004986-e2004986

2018

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Titin Truncating Variants in Dilated Cardiomyopathy - Prevalence and Genotype-Phenotype Correlations

PloS one, 2017-01, Vol.12 (1), p.e0169007-e0169007

2017

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Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1

Nature Immunology, 2007-08, Vol.8 (8), p.856-863

2007

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Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death

Genes & development, 2010-08, Vol.24 (15), p.1608-1613

2010

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Rapid target gene validation in complex cancer mouse models using re‐derived embryonic stem cells

EMBO molecular medicine, 2014-02, Vol.6 (2), p.212-225

2014

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The ChemSM-Hub project in the light of a new paradigm for chemical safety management

International journal of occupational medicine and environmental health, 2020-04, Vol.33 (3), p.247-261

2020

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Using the GEMM-ESC strategy to study gene function in mouse models

Nature protocols, 2015-11, Vol.10 (11), p.1755-1785

2015

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Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa

The Journal of cell biology, 2007-02, Vol.176 (4), p.415-424

2007

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BH3-only proteins Puma and Bim are rate-limiting for γ-radiation– and glucocorticoid-induced apoptosis of lymphoid cells in vivo

Blood, 2005-12, Vol.106 (13), p.4131-4138

2005

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Maximal killing of lymphoma cells by DNA damage–inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim

Blood, 2010-12, Vol.116 (24), p.5256-5267

2010

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Good performance of the criteria of American College of Medical Genetics and Genomics/Association for Molecular Pathology in prediction of pathogenicity of genetic variants causing thoracic aortic aneurysms and dissections

Journal of translational medicine, 2022-01, Vol.20 (1), p.42-42, Article 42

2022

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The mammary stem cell field wakes up to hibernating cells

Stem cell investigation, 2017-05, Vol.4 (6), p.45-45

Michalak, Ewa M

2017

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A Novel BH3 Ligand That Selectively Targets Mcl-1 Reveals That Apoptosis Can Proceed without Mcl-1 Degradation

The Journal of cell biology, 2008-01, Vol.180 (2), p.341-355

2008

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Caloric restriction modulates Mcl-1 expression and sensitizes lymphomas to BH3 mimetic in mice

Blood, 2013-10, Vol.122 (14), p.2402-2411

2013

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Transforming Growth Factor-β Directly Induces p53-up-regulated Modulator of Apoptosis (PUMA) during the Rapid Induction of Apoptosis in Myc-driven B-cell Lymphomas

The Journal of biological chemistry, 2013-02, Vol.288 (7), p.5198-5209

2013

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The roles of DNA, RNA and histone methylation in ageing and cancer

DNA Damage-Induced Primordial Follicle Oocyte Apoptosis and Loss of Fertility Require TAp63-Mediated Induction of Puma and Noxa

p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa

Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer

Dysregulation of histone methyltransferases in breast cancer – Opportunities for new targeted therapies?

Developmental stage-specific contribution of LGR5+ cells to basal and luminal epithelial lineages in the postnatal mammary gland

ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim

p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

Sudden cardiac death risk in hypertrophic cardiomyopathy: comparison between echocardiography and magnetic resonance imaging

Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

Titin Truncating Variants in Dilated Cardiomyopathy - Prevalence and Genotype-Phenotype Correlations

Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1

Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death

Rapid target gene validation in complex cancer mouse models using re‐derived embryonic stem cells

The ChemSM-Hub project in the light of a new paradigm for chemical safety management

Using the GEMM-ESC strategy to study gene function in mouse models

Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa

BH3-only proteins Puma and Bim are rate-limiting for γ-radiation– and glucocorticoid-induced apoptosis of lymphoid cells in vivo

Maximal killing of lymphoma cells by DNA damage–inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim

Good performance of the criteria of American College of Medical Genetics and Genomics/Association for Molecular Pathology in prediction of pathogenicity of genetic variants causing thoracic aortic aneurysms and dissections

The mammary stem cell field wakes up to hibernating cells

A Novel BH3 Ligand That Selectively Targets Mcl-1 Reveals That Apoptosis Can Proceed without Mcl-1 Degradation

Caloric restriction modulates Mcl-1 expression and sensitizes lymphomas to BH3 mimetic in mice

Transforming Growth Factor-β Directly Induces p53-up-regulated Modulator of Apoptosis (PUMA) during the Rapid Induction of Apoptosis in Myc-driven B-cell Lymphomas

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