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IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses

Nature communications, 2020-06, Vol.11 (1), p.2779-2779, Article 2779

2020

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The role of endocytic trafficking in antigen T cell receptor activation

Biomedical Journal, 2022-04, Vol.45 (2), p.310-320

2022

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Cutting Edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme

The Journal of immunology (1950), 2011-02, Vol.186 (4), p.1909-1913

2011

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Innate Immune Signals Induce Anterograde Endosome Transport Promoting MHC Class I Cross-Presentation

Cell reports (Cambridge), 2018-09, Vol.24 (13), p.3568-3581

2018

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A new role for Zn(II) aminopeptidases: antigenic peptide generation and destruction

Current pharmaceutical design, 2009-11, Vol.15 (31), p.3656-3670

2009

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Identification of duloxetine to treat aniridia‐related keratopathy: Link to inflammation?

Acta ophthalmologica (Oxford, England), 2024-01, Vol.102 (S279), p.n/a

2024

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Identification of duloxetine to treat aniridia‐related keratopathy: Link to inflammation?

Acta ophthalmologica (Oxford, England), 2024-01, Vol.102 (S279), p.n/a

2024

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The Role of Insulin Regulated Aminopeptidase in Endocytic Trafficking and Receptor Signaling in Immune Cells

Frontiers in molecular biosciences, 2020-10, Vol.7, p.583556-583556

2020

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Activating FcγR function depends on endosomal-signaling platforms

iScience, 2023-07, Vol.26 (7), p.107055-107055, Article 107055

2023

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The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1

PloS one, 2008-11, Vol.3 (11), p.e3658-e3658

2008

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IRAP Endosomes Control Phagosomal Maturation in Dendritic Cells

Frontiers in cell and developmental biology, 2020-12, Vol.8, p.585713-585713

2020

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Peptide trimming by endoplasmic reticulum aminopeptidases: Role of MHC class I binding and ERAP dimerization

Human immunology, 2019-05, Vol.80 (5), p.290-295

2019

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Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1

The Journal of immunology (1950), 2010-08, Vol.185 (3), p.1584-1592

2010

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Deletion of the fission yeast homologue of human insulinase reveals a TORC1-dependent pathway mediating resistance to proteotoxic stress

PloS one, 2013-06, Vol.8 (6), p.e67705

2013

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M1-aminopeptidase family — beyond antigen-trimming activities

Current opinion in immunology, 2023-08, Vol.83, p.102337-102337, Article 102337

2023

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ERAP1-ERAP2 dimerization increases peptide-trimming efficiency

The Journal of immunology (1950), 2014-07, Vol.193 (2), p.901-908

2014

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ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing

Scientific reports, 2016-08, Vol.6 (1), p.28902-28902, Article 28902

2016

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Peptidases trimming MHC class I ligands

Current opinion in immunology, 2013-02, Vol.25 (1), p.90-96

2013

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Is there a place and role for endocytic TCR signaling?

Immunological reviews, 2019-09, Vol.291 (1), p.57-74

2019

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La signalisation endosomique impliquant la chaîne ζ du récepteur des lymphocytes T est nécessaire à leur survie dans les organes lymphoïdes secondaires

M.S. Médecine sciences, 2020-12, Vol.36 (12), p.1213-1215

2020

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Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1

Journal of medicinal chemistry, 2020-01, Vol.63 (1), p.103-121

2020

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Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1

Nature structural & molecular biology, 2011-05, Vol.18 (5), p.604-613

2011

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The function of IRAP+ endosomes in T cells

Molecular immunology, 2022-10, Vol.150, p.13

2022

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Impact of the TAP-like transporter in antigen presentation and phagosome maturation

Molecular immunology, 2019-09, Vol.113, p.75-86

2019

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Trimming of MHC Class I Ligands by ERAP Aminopeptidases

Methods in molecular biology (Clifton, N.J.), 2019-01, Vol.1988, p.31

2019

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IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses

The role of endocytic trafficking in antigen T cell receptor activation

Cutting Edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme

Innate Immune Signals Induce Anterograde Endosome Transport Promoting MHC Class I Cross-Presentation

A new role for Zn(II) aminopeptidases: antigenic peptide generation and destruction

Identification of duloxetine to treat aniridia‐related keratopathy: Link to inflammation?

Identification of duloxetine to treat aniridia‐related keratopathy: Link to inflammation?

The Role of Insulin Regulated Aminopeptidase in Endocytic Trafficking and Receptor Signaling in Immune Cells

Activating FcγR function depends on endosomal-signaling platforms

The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1

IRAP Endosomes Control Phagosomal Maturation in Dendritic Cells

Peptide trimming by endoplasmic reticulum aminopeptidases: Role of MHC class I binding and ERAP dimerization

Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1

Deletion of the fission yeast homologue of human insulinase reveals a TORC1-dependent pathway mediating resistance to proteotoxic stress

M1-aminopeptidase family — beyond antigen-trimming activities

ERAP1-ERAP2 dimerization increases peptide-trimming efficiency

ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing

Peptidases trimming MHC class I ligands

Is there a place and role for endocytic TCR signaling?

La signalisation endosomique impliquant la chaîne ζ du récepteur des lymphocytes T est nécessaire à leur survie dans les organes lymphoïdes secondaires

Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1

Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1

The function of IRAP+ endosomes in T cells

Impact of the TAP-like transporter in antigen presentation and phagosome maturation

Trimming of MHC Class I Ligands by ERAP Aminopeptidases

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