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Gram-Negative Bacterial Lysins

Antibiotics (Basel), 2020-02, Vol.9 (2), p.74

2020

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Novel phage lysin capable of killing the multidrug-resistant gram-negative bacterium Acinetobacter baumannii in a mouse bacteremia model

Antimicrobial agents and chemotherapy, 2015-04, Vol.59 (4), p.1983-1991

2015

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Strains of bacterial species induce a greatly varied acute adaptive immune response: The contribution of the accessory genome

PLoS pathogens, 2018-01, Vol.14 (1), p.e1006726-e1006726

2018

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Novel Bacteriophage Lysin with Broad Lytic Activity Protects against Mixed Infection by Streptococcus pyogenes and Methicillin-Resistant Staphylococcus aureus

Antimicrobial Agents and Chemotherapy, 2013-06, Vol.57 (6), p.2743-2750

2013

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Using a Novel Lysin To Help Control Clostridium difficile Infections

Antimicrobial agents and chemotherapy, 2015-12, Vol.59 (12), p.7447-7457

2015

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PaP1, a Broad-Spectrum Lysin-Derived Cationic Peptide to Treat Polymicrobial Skin Infections

Frontiers in microbiology, 2022-03, Vol.13, p.817228-817228

2022

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Anti-CRISPR proteins trigger a burst of CRISPR-Cas9 expression that enhances phage defense

Cell reports (Cambridge), 2024-03, Vol.43 (3), p.113849-113849, Article 113849

2024

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Targeted Curing of All Lysogenic Bacteriophage from Streptococcus pyogenes Using a Novel Counter-selection Technique

PloS one, 2016-01, Vol.11 (1), p.e0146408-e0146408

2016

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The Phage Lysin PlySs2 Decolonizes Streptococcus suis from Murine Intranasal Mucosa

PloS one, 2017-01, Vol.12 (1), p.e0169180-e0169180

2017

Volltextzugriff (PDF)

Use of a bacteriophage lysin to identify a novel target for antimicrobial development

PloS one, 2013-04, Vol.8 (4), p.e60754-e60754

2013

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Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials

Nature biotechnology, 2014-11, Vol.32 (11), p.1146-1150

2014

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Isolation of Phage Lysins That Effectively Kill Pseudomonas aeruginosa in Mouse Models of Lung and Skin Infection

Antimicrobial agents and chemotherapy, 2019-07, Vol.63 (7)

2019

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Elimination of Chromosomal Island SpyCIM1 from Streptococcus pyogenes Strain SF370 Reverses the Mutator Phenotype and Alters Global Transcription

PloS one, 2015-12, Vol.10 (12), p.e0145884-e0145884

2015

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Lysocins: Bioengineered Antimicrobials That Deliver Lysins across the Outer Membrane of Gram-Negative Bacteria

Antimicrobial agents and chemotherapy, 2019-06, Vol.63 (6)

2019

Volltextzugriff (PDF)

Novel Engineered Peptides of a Phage Lysin as Effective Antimicrobials against Multidrug-Resistant Acinetobacter baumannii

Antimicrobial agents and chemotherapy, 2016-05, Vol.60 (5), p.2671-2679

2016

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PlyKp104, a Novel Phage Lysin for the Treatment of Klebsiella pneumoniae, Pseudomonas aeruginosa, and Other Gram-Negative ESKAPE Pathogens

Antimicrobial agents and chemotherapy, 2023-05, Vol.67 (5), p.e0151922-e0151922

2023

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A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression

Cell, 2021-02, Vol.184 (3), p.675-688.e19

2021

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Watch your Strep: Streptococcus pyogenes is a preventable cause of maternal death

Future microbiology, 2022-03, Vol.17 (5), p.319-323

2022

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A Highly Active and Negatively Charged Streptococcus pyogenes Lysin with a Rare D-Alanyl-L-Alanine Endopeptidase Activity Protects Mice against Streptococcal Bacteremia

Antimicrobial agents and chemotherapy, 2014-06, Vol.58 (6), p.3073-3084

2014

Volltextzugriff (PDF)

A novel chimeric phage lysin with high in vitro and in vivo bactericidal activity against Streptococcus pneumoniae

Journal of antimicrobial chemotherapy, 2015-06, Vol.70 (6), p.1763-1773

2015

Volltextzugriff (PDF)

M.SpyI, a DNA Methyltransferase Encoded on a mefA Chimeric Element, Modifies the Genome of Streptococcus pyogenes

Journal of Bacteriology, 2007-02, Vol.189 (3), p.1044-1054

2007

Volltextzugriff (PDF)

Prophage integration into CRISPR loci enables evasion of antiviral immunity in Streptococcus pyogenes

Nature microbiology, 2021-12, Vol.6 (12), p.1516

2021

Volltextzugriff (PDF)

Evaluation of Topical Lysostaphin as a Novel Treatment for Instrumented Rhesus Macaques (Macaca mulatta) Infected with Methicillin-Resistant Staphylococcus aureus

Comparative medicine, 2020-10, Vol.70 (5), p.335-347

2020

Volltextzugriff (PDF)

Novel algorithms reveal streptococcal transcriptomes and clues about undefined genes

PLoS computational biology, 2007-07, Vol.3 (7), p.e132-e132

2007

Volltextzugriff (PDF)

Staphylococcus aureus Infecting and Colonizing Experimental Animals, Macaques, in a Research Animal Facility

Microbial drug resistance (Larchmont, N.Y.), 2019-01, Vol.25 (1), p.54

2019

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Gram-Negative Bacterial Lysins

Novel phage lysin capable of killing the multidrug-resistant gram-negative bacterium Acinetobacter baumannii in a mouse bacteremia model

Strains of bacterial species induce a greatly varied acute adaptive immune response: The contribution of the accessory genome

Novel Bacteriophage Lysin with Broad Lytic Activity Protects against Mixed Infection by Streptococcus pyogenes and Methicillin-Resistant Staphylococcus aureus

Using a Novel Lysin To Help Control Clostridium difficile Infections

PaP1, a Broad-Spectrum Lysin-Derived Cationic Peptide to Treat Polymicrobial Skin Infections

Anti-CRISPR proteins trigger a burst of CRISPR-Cas9 expression that enhances phage defense

Targeted Curing of All Lysogenic Bacteriophage from Streptococcus pyogenes Using a Novel Counter-selection Technique

The Phage Lysin PlySs2 Decolonizes Streptococcus suis from Murine Intranasal Mucosa

Use of a bacteriophage lysin to identify a novel target for antimicrobial development

Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials

Isolation of Phage Lysins That Effectively Kill Pseudomonas aeruginosa in Mouse Models of Lung and Skin Infection

Elimination of Chromosomal Island SpyCIM1 from Streptococcus pyogenes Strain SF370 Reverses the Mutator Phenotype and Alters Global Transcription

Lysocins: Bioengineered Antimicrobials That Deliver Lysins across the Outer Membrane of Gram-Negative Bacteria

Novel Engineered Peptides of a Phage Lysin as Effective Antimicrobials against Multidrug-Resistant Acinetobacter baumannii

PlyKp104, a Novel Phage Lysin for the Treatment of Klebsiella pneumoniae, Pseudomonas aeruginosa, and Other Gram-Negative ESKAPE Pathogens

A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression

Watch your Strep: Streptococcus pyogenes is a preventable cause of maternal death

A Highly Active and Negatively Charged Streptococcus pyogenes Lysin with a Rare D-Alanyl-L-Alanine Endopeptidase Activity Protects Mice against Streptococcal Bacteremia

A novel chimeric phage lysin with high in vitro and in vivo bactericidal activity against Streptococcus pneumoniae

M.SpyI, a DNA Methyltransferase Encoded on a mefA Chimeric Element, Modifies the Genome of Streptococcus pyogenes

Prophage integration into CRISPR loci enables evasion of antiviral immunity in Streptococcus pyogenes

Evaluation of Topical Lysostaphin as a Novel Treatment for Instrumented Rhesus Macaques (Macaca mulatta) Infected with Methicillin-Resistant Staphylococcus aureus

Novel algorithms reveal streptococcal transcriptomes and clues about undefined genes

Staphylococcus aureus Infecting and Colonizing Experimental Animals, Macaques, in a Research Animal Facility

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